ChemicalBook > CAS DataBase List > 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE

1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE

Product Name
1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
CAS No.
57060-88-5
Chemical Name
1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
Synonyms
DL-Tic-OMe.HCl;(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic;METHYLTETRAHYDROISOQUINOLINE CARBOXYLATEHYDROCHLORIDE;Methyl 1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride;METHYL 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE;S-(-)-1,2,3,4-Tetrahydro-3-IsoquinolinecarboxylicAcidMethylEsterHcl;(S)-Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride;1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-, METHYL ESTER, HYDROCHLORIDE;1,2,3,4-tetrahydro-3-Isoquinolinecarboxylic acid methyl ester, hydrochloride (1:1)
CBNumber
CB0310222
Molecular Formula
C11H14ClNO2
Formula Weight
227.69
MOL File
57060-88-5.mol
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1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
White to off-white Solid
CAS DataBase Reference
57060-88-5(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M338023
Product name
Methyl1,2,3,4-tetrahydroisoquinoline-3-carboxylatehydrochloride
Packaging
50mg
Price
$45
Updated
2021/12/16
Ark Pharm
Product number
P000102631
Product name
Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride
Purity
97%
Packaging
250mg
Price
$24
Updated
2021/12/16
Ark Pharm
Product number
P000102631
Product name
Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride
Purity
97%
Packaging
1g
Price
$59
Updated
2021/12/16
Ark Pharm
Product number
P000102631
Product name
Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride
Purity
97%
Packaging
5g
Price
$249
Updated
2021/12/16
Ark Pharm
Product number
P000102631
Product name
Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride
Purity
97%
Packaging
10g
Price
$422
Updated
2021/12/16
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1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

67123-97-1

57060-88-5

GENERAL PROCEDURE: The chiral monomer (R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (4.27 g, 20 mmol) was dissolved in methanol (20 mL) and the solution was cooled to 0 °C. Thionyl chloride (5.2 mL) was added slowly and dropwise with stirring. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure to afford the white solid product (R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester hydrochloride (5.29 g, 94.4% yield). The product was confirmed by 1H NMR (300 MHz, D2O, rt): δ 7.45-7.24 (m, 4H), 4.60 (d, J = 5.5 Hz, 1H), 4.56 (d, J = 5.4 Hz, 1H), 4.53 (br s, 1H), 3.93 (s, 3H), 3.53 (dd, J = 17.4, 5.5 Hz, 1H) 3.32 (dd, J = 17.3, 10.9 Hz, 1H). High resolution electrospray ionization mass spectrometry (HR ESIMS) showed m/z 192.1028 [M + H]+ (calculated value 192.1025), further confirming the structure of the product.

References

[1] European Journal of Medicinal Chemistry, 2016, vol. 121, p. 272 - 282

1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Suppliers

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View Lastest Price from 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 57060-88-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 57060-88-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-08

57060-88-5, 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDERelated Search:

Quinapril benzyl ester maleate 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-8-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-5-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Benzyl (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride Benzyl (S)-(-)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate p-toluenesulfonic acid salt (S)-2-[(S)-2-((S)-1-Ethoxycarbonyl-3-phenylpropylamino)propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid benzyl ester Benzyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate L-ETHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE CarboxylicAcidPhenylMethylEsterHydrochloride,QuinaprilHcl L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID T-BUTYL ESTER (S)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC TERT BUTYL ESTER 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid methyl ester hydrochloride (S,S)-2-(2-AMINO-3-METHYL-BUTYRYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID BENZYL ESTER, HCL (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE-CARBOXYLIC ACID T-BUTYL ESTER PTSA SALT

  • METHYL 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE
  • METHYLTETRAHYDROISOQUINOLINE CARBOXYLATEHYDROCHLORIDE
  • 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
  • 3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-, METHYL ESTER, HYDROCHLORIDE
  • 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-, methyl ester, hydrochloride (1:1)
  • Methyl 1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride
  • S-(-)-1,2,3,4-Tetrahydro-3-IsoquinolinecarboxylicAcidMethylEsterHcl
  • (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic
  • (S)-Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride
  • DL-Tic-OMe.HCl
  • 1,2,3,4-tetrahydro-3-Isoquinolinecarboxylic acid methyl ester, hydrochloride (1:1)
  • 57060-88-5