DPC-681
- Product Name
- DPC-681
- CAS No.
- 284661-68-3
- Chemical Name
- DPC-681
- Synonyms
- DPC-681;DPH-153893;DPC 681,DPC681;DPC-681 (DPH-153893);L-Valinamide, N-[(3-fluorophenyl)methyl]glycyl-N-[(1S,2R)-3-[[(3-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-3-methyl-
- CBNumber
- CB03121092
- Molecular Formula
- C35H48FN5O5S
- Formula Weight
- 669.85
- MOL File
- 284661-68-3.mol
DPC-681 Property
- Density
- 1.217±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 13.52±0.20(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-5439
- Product name
- DPC-681
- Purity
- 99.72%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-5439
- Product name
- DPC-681
- Purity
- 99.72%
- Packaging
- 5mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- orb611409
- Product name
- DPC-681
- Packaging
- 5mg
- Price
- $615.4
- Updated
- 2021/12/16
- Product number
- CS-5439
- Product name
- DPC-681
- Purity
- 99.72%
- Packaging
- 10mg
- Price
- $960
- Updated
- 2021/12/16
- Product number
- orb611409
- Product name
- DPC-681
- Packaging
- 10mg
- Price
- $970.7
- Updated
- 2021/12/16
DPC-681 Chemical Properties,Usage,Production
Uses
DPC-681 is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM. IC50 value: 4 - 40 nM [1] Target: HIV protease in vitro: DPC 681 is extremely potent inhibitor of wild-type HIV-1. When all of the HIV-1 strains tested are considered, the average concentrations required for 90% inhibition of replication were 7.3 ± 3.4 for DPC 681. DPC 681 shows no loss in potency toward recombinant mutant HIVs with the D30N mutation and a fivefold or smaller loss in potency toward mutant variants with three to five amino acid substitutions. [1] in vivo: The total body clearance (CL) of DPC 681 in dogs was high (1.8 liter/h/kg) equaling hepatic blood flow for this species (1.8 liter/h/kg). After an oral dosing, the Cmax increased ninefold between the 10- and 30-mg/kg DPC 681 dose groups. Bioavailability also increased between the 10- and 30-mg/kg dose groups (18.3 and 78.1%, respectively). These data suggest that hepatic extraction (first-pass effect) can be saturated in the dog. [1]
IC 50
HIV-1
References
[1] Kaltenbach RF 3rd, et al. DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8. DOI:10.1128/AAC.45.11.3021-3028.2001
DPC-681 Preparation Products And Raw materials
Raw materials
Preparation Products
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