ChemicalBook > CAS DataBase List > 1-BROMO-2-METHOXYNAPHTHALENE

1-BROMO-2-METHOXYNAPHTHALENE

Product Name: 1-BROMO-2-METHOXYNAPHTHALENE
CAS No.: 3401-47-6
Chemical Name: 1-BROMO-2-METHOXYNAPHTHALENE
Synonyms: 1-Bromo-2-methoxynapthalene;2-Methoxy-1-naphtyl bromide;1-BROMO-2-METHOXYNAPHTHALENE;Naphthalene, 1-broMo-2-Methoxy-;1-Bromo-2-Naphthalene Methyl Ether;1-Bromo-2-methoxynaphthalene, >=97%
CBNumber: CB0312286
Molecular Formula: C11H9BrO
Formula Weight: 237.09
MOL File: 3401-47-6.mol

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1-BROMO-2-METHOXYNAPHTHALENE Property

Melting point:: 80-83 °C
Boiling point:: 190-192 °C(Press: 22 Torr)
Density: 1.447±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
color: White to Light yellow
Water Solubility: Slightly soluble in water.
BRN: 2045600
InChI: InChI=1S/C11H9BrO/c1-13-10-7-6-8-4-2-3-5-9(8)11(10)12/h2-7H,1H3
InChIKey: XNIGURFWNPLWJM-UHFFFAOYSA-N
SMILES: C1(Br)=C2C(C=CC=C2)=CC=C1OC
CAS DataBase Reference: 3401-47-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29093090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B6103
Product name: 1-Bromo-2-methoxynaphthalene
Packaging: 5G
Price: $54
Updated: 2025/07/31

TCI Chemical

Product number: B6103
Product name: 1-Bromo-2-methoxynaphthalene
Packaging: 25G
Price: $188
Updated: 2025/07/31

TRC

Product number: B685775
Product name: 1-Bromo-2-methoxy-naphthalene
Packaging: 100g
Price: $495
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0009985
Product name: 1-BROMO-2-METHOXYNAPHTHALENE
Purity: 95.00%
Packaging: 1G
Price: $629.53
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140571
Product name: 1-Bromo-2-methoxynaphthalene
Packaging: 100g
Price: $636
Updated: 2021/12/16

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1-BROMO-2-METHOXYNAPHTHALENE Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

1-Bromo-2-methoxy-naphthalene is a useful synthetic intermediate. It is used as a reagent to synthesize a catalyst for highly enantioselective aziridination of styrene derivatives. It can also be used to prepare biaryls or biheterocycles by palladium-catalyzed Ullmann coupling.

Synthesis

573-97-7

74-88-4

3401-47-6

In a 500 mL round-bottomed three-necked flask, 1-bromo-2-naphthol (30.0 g, 134.5 mmol), potassium hydroxide (KOH, 11.3 g, 201.7 mmol) and 300 mL of dimethylsulfoxide (DMSO) were added, and stirred under nitrogen protection for 10 min. Subsequently, the reaction system was cooled in an ice-water bath and iodomethane (28.6 g, 201.7 mmol) was added dropwise slowly. After the dropwise addition, stirring was continued at room temperature under nitrogen atmosphere for 12 h. The reaction was then warmed up to 50 °C for 1 h. The reaction was then completed by cooling to 50 °C for 10 min. After completion of the reaction, it was cooled to room temperature. The reaction mixture was poured into 500 mL of water and extracted with ether. The organic phase was washed three times with distilled water and dried over anhydrous magnesium sulfate (MgSO4). After the solvent was evaporated under reduced pressure, it was purified by silica gel column chromatography (eluent: n-hexane) to afford 1-bromo-2-methoxynaphthalene 22.0 g (yield 69.0%) as a white solid.

References

[1] Patent: KR2016/17530, 2016, A. Location in patent: Paragraph 0238; 0241; 0245; 0246
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 24, p. 4800 - 4818
[3] Journal of Organic Chemistry, 2000, vol. 65, # 5, p. 1511 - 1515
[4] Patent: JP5656843, 2015, B2. Location in patent: Paragraph 0092; 0093
[5] Journal of the Chemical Society, 1900, vol. 77, p. 37

1-BROMO-2-METHOXYNAPHTHALENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BROMO-2-METHOXYNAPHTHALENE Suppliers

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View Lastest Price from 1-BROMO-2-METHOXYNAPHTHALENE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-BROMO-2-METHOXYNAPHTHALENE 3401-47-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Shenzhen Nexcon Pharmatechs Ltd.

Product: 1-BROMO-2-METHOXYNAPHTHALENE 3401-47-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 2000
Release date: 2025-04-18

Henan Fengda Chemical Co., Ltd

Product: 1-Bromo-2-methoxynaphthalene 3401-47-6
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-31

3401-47-6, 1-BROMO-2-METHOXYNAPHTHALENERelated Search:

1-BROMO-2-METHOXYNAPHTHALENE 2-ACETYL-5-BROMO-6-METHOXYNAPHTHALENE,6-ACETYL-1-BROMO-2-METHOXYNAPHTHALENE 1-bromo-4-methoxy-naphthalene 2-bromo-6-methoxynaphthalene (intermediate of nabumetone),6-BROMO-2-METHOXYNAPHTHALENE,2-BROMO-6-METHOXYNAPHTHALENE 1-(5-BROMO-6-METHOXY-2-NAPHTHYL)-1-PROPANONE 2-(1-BROMO-2-NAPHTHYLOXY)ETHANENITRILE 2-(1-BROMO(2-NAPHTHYLOXY))-1-(HYDROXYIMINO)ETHYLAMINE METHYL 4,7-DIBROMO-3-METHOXY-2-NAPHTHOATE 2-(BENZYLOXY)-1-BROMO-6-METHOXYNAPHTHALENE 2-Bromo-3-methoxynaphthalene 6-bromo-1-methoxynaphthalene 6-BROMO-2-METHOXYNAPHTHALENE-1-CARBALDEHYDE 2-ACERYL-5-BROMO-6-METHOXY NAPHTHALENE NAPROXEN IMP. N (EP):2-BROMO-6-METHOXYNAPHTHALENE 1-(5-BROMO-6-METHOXY-2-NAPHTHYL)-3-(DIMETHYLAMINO)-2-METHYL-2-PROPEN-1-ONE ETHYL 2-(1-BROMO-2-NAPHTHYLOXY)ACETATE 1-BROMO-6-[1-(4-FLUOROPHENYL)-4-METHYL-1H-PYRAZOL-3-YL]-2-NAPHTHYL METHYL ETHER 3-(5-BROMO-6-METHOXY-2-NAPHTHYL)-2-METHYL-3-OXOPROPANAL O-(2,6-DICHLOROBENZYL)OXIME

1-BROMO-2-METHOXYNAPHTHALENE

2-Methoxy-1-naphtyl bromide

Naphthalene, 1-broMo-2-Methoxy-

1-Bromo-2-methoxynapthalene

1-Bromo-2-methoxynaphthalene, >=97%

1-Bromo-2-Naphthalene Methyl Ether

3401-47-6

Ethers

Organic Building Blocks

Oxygen Compounds

Building Blocks

Ethers

Organic Building Blocks

Oxygen Compounds

Building Blocks

C11

Chemical Synthesis

Organic Building Blocks

Oxygen Compounds