Methyl lactate Property

Melting point:

-66°C

Boiling point:

35 °C (6 mmHg)

alpha 

[α]D20+1.410～+1.418

Density 

1.093 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.413

Flash point:

49 °C

storage temp. 

Flammables area

form 

Liquid

pka

13.07±0.20(Predicted)

color 

Clear colorless to pale yellow

Specific Gravity

1.09

Water Solubility 

miscible, hydrolyses

Sensitive 

Moisture Sensitive

Merck 

14,6094

BRN 

1720586

InChIKey

LPEKGGXMPWTOCB-UHFFFAOYSA-N

LogP

-0.670 (est)

CAS DataBase Reference

547-64-8(CAS DataBase Reference)

NIST Chemistry Reference

Propanoic acid, 2-hydroxy-, methyl ester(547-64-8)

EPA Substance Registry System

Methyl lactate (547-64-8)

Safety

Hazard Codes 

Xi

Risk Statements 

10-36/37

Safety Statements 

24-24/25

RIDADR 

UN 3272 3/PG 3

WGK Germany 

1

RTECS 

OD5670000

F 

21

TSCA 

Yes

HazardClass 

3.2

PackingGroup 

III

HS Code 

29181100

Hazardous Substances Data

547-64-8(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Methyl lactate Chemical Properties,Usage,Production

Chemical Properties

Methyl lactate is a colorless transparent liquid. It is soluble/miscible in water, acetone, ethyl alcohol, and other organic solvents. It is used as a cellulose acetate solvent.

Uses

Methyl lactate is used as a solvent for nitrocellulose, cellulase acetate, cellulase acetobutyrote and cellulase acetaprapionate. It is used in the manufacture of lacquers and dopes where it contributes high tolerance for diluents, good flaw and blush resistance.

Definition

ChEBI: Methyl lactate is a lactate ester resulting from the formal condensation of the carboxy group of 2-hydroxypropanoic acid with methanol. It has a role as a metabolite. It is a lactate ester and a methyl ester.

Hazard

Moderate fire risk.

Safety Profile

Methyl lactate has been classed as non-irritant to the eyes of guinea pigs.
The estimated average lethal dose for the female rat following i.p. injection of methyl lactate was >2000 mg/kg body weight. Observations included narcosis, respiratory distress and peritoneal adhesions. The estimated non toxic dose and estimated maximum dose without gross lesions at necropsy was 500 mg/kg body weight.

Synthesis

Methyl lactate is prepared by the esterification of methyl alcohol with lactic acid.

Purification Methods

Methyl lactate is easily hydrolyzed and often contains impurities such as free lactic acid, methanol and water. Free acid can be removed by washing after neutralization with alkali. Moisture can be removed by azeotropic distillation of an azeotropic mixture with benzene. Then, it was purified by distillation under reduced pressure. Since calcium chloride and the like form molecular compounds with methyl lactate, they cannot be used as desiccants. When the methyl lactate is mixed with water, it can be extracted and recovered with benzene, ether, etc.