ChemicalBook > CAS DataBase List > MK-2 Inhibitor III

MK-2 Inhibitor III

Product Name
MK-2 Inhibitor III
CAS No.
1186648-22-5
Chemical Name
MK-2 Inhibitor III
Synonyms
MK2-IN-3 hydrate;MK-2 Inhibitor III;MK-2 INHIBITOR III (COMPOUND 16);MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem;2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one:hydrate;2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate;Inhibitor,MAP kinase activated protein kinase 2,inhibit,MK2 IN 3 hydrate,MAPKAP kinase 2,MK-2-IN-3 hydrate,MAPK activated protein kinase 2,MK2IN3 hydrate,MAPKAPK2 (MK2),Mitogen-activated protein kinase activated protein kinase 2
CBNumber
CB03136757
Molecular Formula
C21H18N4O2
Formula Weight
358.4
MOL File
1186648-22-5.mol
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MK-2 Inhibitor III Property

Melting point:
>255°C (dec.)
storage temp. 
+2C to +8C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Pale yellow solid
color 
Off-White to Pale Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15943
Product name
MK2 Inhibitor III
Purity
≥95%
Packaging
500μg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
15943
Product name
MK2 Inhibitor III
Purity
≥95%
Packaging
1mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
15943
Product name
MK2 Inhibitor III
Purity
≥95%
Packaging
5mg
Price
$225
Updated
2024/03/01
AK Scientific
Product number
3003DC
Product name
MK-2InhibitorIII
Packaging
5mg
Price
$348
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
47746
Product name
MK2InhibitorIII
Packaging
2.5mg
Price
$625
Updated
2021/12/16
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MK-2 Inhibitor III Chemical Properties,Usage,Production

Description

MAP kinase-activated protein kinase 2 (MAPKAP2, MK2) is a stress-activated serine/threonine protein kinase that is phosphorylated by p38 MAP kinase and is involved in diverse cellular functions with a central role in inflammation. MK2 inhibitor III is a potent, cell-permeable inhibitor of MK2 (IC50 = 8.5 nM). It less potently blocks MK3 and MK5 (IC50s = 210 and 81 nM, respectively) and is weak or inactive against several other kinases, including other p38 MAP kinase targets. MK2 inhibitor III prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells (IC50 = 4.4 μM).

Uses

MAP kinase-activated protein kinase 2 (MAPKAP2, MK2) is a stress-activated serine/threonine protein kinase that is phosphorylated by p38 MAP kinase and is involved in diverse cellular functions with a central role in inflammation. MK2 inhibitor III is a potent, cell-permeable inhibitor of MK2 (IC50 = 8.5 nM). It less potently blocks MK3 and MK5 (IC50s = 210 and 81 nM, respectively) and is weak or inactive against several other kinases, including other p38 MAP kinase targets. MK2 inhibitor III prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells (IC50 = 4.4 μM).[Cayman Chemical]

MK-2 Inhibitor III Preparation Products And Raw materials

Raw materials

Preparation Products

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1186648-22-5, MK-2 Inhibitor IIIRelated Search:


  • MK-2 Inhibitor III
  • 2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one:hydrate
  • MK-2 INHIBITOR III (COMPOUND 16)
  • MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem
  • MK2-IN-3 hydrate
  • 2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate
  • Inhibitor,MAP kinase activated protein kinase 2,inhibit,MK2 IN 3 hydrate,MAPKAP kinase 2,MK-2-IN-3 hydrate,MAPK activated protein kinase 2,MK2IN3 hydrate,MAPKAPK2 (MK2),Mitogen-activated protein kinase activated protein kinase 2
  • 1186648-22-5