Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Product Name: Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
CAS No.: 79660-46-1
Chemical Name: Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
Synonyms: dm-7;SBB012483;BRN 4814660;6,7,8-trifL;inecarboxyL;ZINC00403393;521647_ALDRICH;CycliccompoundofLomefloxacin;uoro-1,4-dihydro-4-oxo-3-quinoL;3-ethoxycarbonyl-6,7,8-trifluoro-4-quinolinolate
CBNumber: CB0313849
Molecular Formula: C12H8F3NO3
Formula Weight: 271.19
MOL File: 79660-46-1.mol

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Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate Property

Melting point:: 275 °C (dec.) (lit.)
Boiling point:: 344.3±42.0 °C(Predicted)
Density: 1.451
storage temp.: Sealed in dry,Room Temperature
pka: -0.92±0.70(Predicted)
Appearance: Off-white to light brown Solid
CAS DataBase Reference: 79660-46-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 2
RTECS: VB2009830
HazardClass: IRRITANT
HS Code: 29334910

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 521647
Product name: Ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Purity: 98%
Packaging: 10g
Price: $86.9
Updated: 2023/06/20

TRC

Product number: E930610
Product name: Ethyl6,7,8-Trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
Packaging: 250mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: 2444AC
Product name: Ethyl6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
Packaging: 1g
Price: $21
Updated: 2021/12/16

Matrix Scientific

Product number: 065228
Product name: Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
Packaging: 500mg
Price: $237
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0037435
Product name: ETHYL 6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $925.31
Updated: 2021/12/16

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Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate Chemical Properties,Usage,Production

Chemical Properties

beige to beige-brown powder

General Description

Ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate is also referred to as 3-ethoxycarbonyl-6,7,8-trifluoro-1,4-hydro-4-oxoquinoline.

Synthesis

100501-60-8

79660-46-1

General procedure for the synthesis of ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate from diethyl 2-[[(2,3,4-trifluorophenyl)amino]methylene]malonate: Compound 2 (5.30 g, 16.70 mmol) was dissolved in diphenyl ether (35 mL), and the reaction was carried out at reflux for 8 hr at 250 °C. After completion of the reaction, the reaction mixture was cooled and the precipitate precipitated was collected by filtration. The precipitate was washed with hexane and subsequently recrystallized with ethanol to give the target product 3 as a white solid.

References

[1] Synthetic Communications, 2009, vol. 39, # 24, p. 4375 - 4383
[2] Tetrahedron, 2007, vol. 63, # 9, p. 2093 - 2097
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 4, p. 1232 - 1244
[4] Tetrahedron, 1992, vol. 48, # 29, p. 6135 - 6150
[5] Magnetic Resonance in Chemistry, 1996, vol. 34, # 11, p. 972 - 978

Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate Suppliers

Belgium 1 China 58 Europe 2 Germany 2 India 2 Japan 1 Switzerland 1 United Kingdom 5 United States 17 Global 89

J & K SCIENTIFIC LTD.

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Sigma-Aldrich

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View Lastest Price from Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: ETHYL 6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLATE 79660-46-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: ETHYL 6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLATE 79660-46-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 200kg
Release date: 2019-09-10

79660-46-1, Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylateRelated Search:

3-Quinolinecarboxylic acid Ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate 1-CYCLOPROPYL-5-AMIDO-6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3- QUINOLINECARBOXYLIC ACID ETHYL ESTER ETHYL 1-CYCLOPROPYL-5,6,7,8-TETRAFLUORO-4(1H)-OXOQUINOLINE-3-CARBOXYLATE Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 1-CYCLOPROPYL-5-NITRO-6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3- QUINOLINECARBOXYLIC ACID ETHYL ESTER

ETHYL 6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLATE

ETHYL 6,7,8-TRIFLUORO-4-OXOHYDROQUINOLINE-3-CARBOXYLATE

1,4-dihydro-4-oxo-6,7,8-trifluoro-3-quinolinecarboxylicaciethylester

dm-7

ethyl1,4-dihydro-4-oxo-6,7,8-trifluoro-3-quinolinecarboxylate

CycliccompoundofLomefloxacin

6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester

3-ethoxycarbonyl-6,7,8-trifluoro-1,4-hydro-4-oxoquinoline

6,7,8-TRIFLUORO-4-OXOHYDROQUINOLINE-3-CARBOXYLICACIDETHYLESTER

ETHYL-6,7,8-TRIFLUORO-4-OXOHYDROXYQUINOLINE-3-CARBOXYLATE

ETHYL 6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINILINECARBOXYLATE

Ethyl 6,7,8-trifluoro-4-oxohydroquinoline-3-carboxylate,97%

Ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

ethyl 6,7,8-trifluoro-4-oxo-1H-quinoline-3-carboxylate

3-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-6,7,8-trifluoro-, ethyl ester

3-ethoxycarbonyl-6,7,8-trifluoro-4-quinolinolate

521647_ALDRICH

6,7,8-trifluoro-4-keto-1H-quinoline-3-carboxylic acid ethyl ester

6,7,8-trifluoro-4-oxo-1H-quinoline-3-carboxylic acid ethyl ester

BRN 4814660

SBB012483

ZINC00403393

6,7,8-trifL

inecarboxyL

uoro-1,4-dihydro-4-oxo-3-quinoL

3-Quinolinecarboxylic acid, 6,7,8-trifluoro-1,4-dihydro-4-oxo-, ethyl ester

Ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate 98%

ETHYL 6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLATE ISO 9001：2015 REACH

ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

ethyl 6,7,8-trifluoro-4-oxo-3H-quinoline-3-carboxylate

79660-46-1

C12H8F3NO3

Building Blocks

Heterocyclic Building Blocks

Quinolines

Building Blocks

C11 to C30

Chemical Synthesis

Heterocyclic Building Blocks

Quinolines