DM1-Sme
- Product Name
- DM1-Sme
- CAS No.
- 138148-68-2
- Chemical Name
- DM1-Sme
- Synonyms
- DM1-Sme;CS-2715;DM1-SSMe;AP3 Intermidate 2;DM1-SMe, 10 mM in DMSO;MaytansinoidDM4Impurity6;1H-Inden-2-ol,1-amino-2,3-dihydro-,(1R,4S)-;N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine;Maytansine, N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]-;4,24-Dioxa-9,22-diazatetracyclo[19.3.1.1 10,14.03,5]hexacosane,maytansine deriv.
- CBNumber
- CB03139071
- Molecular Formula
- C36H50ClN3O10S2
- Formula Weight
- 784.38
- MOL File
- 138148-68-2.mol
DM1-Sme Property
- Boiling point:
- 957.1±65.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:12.0(Max Conc. mg/mL);15.3(Max Conc. mM)
DMF:16.0(Max Conc. mg/mL);20.4(Max Conc. mM)
DMF:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.2(Max Conc. mM) - form
- A crystalline solid
- pka
- 9.82±0.70(Predicted)
- color
- Off-white to light yellow
- InChIKey
- ZLUUPZXOPGORNG-PGOVPJOUNA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H303May be harmfulif swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H336May cause drowsiness or dizziness
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 22477
- Product name
- DM1-SMe
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 22477
- Product name
- DM1-SMe
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $183
- Updated
- 2024/03/01
- Product number
- 22477
- Product name
- DM1-SMe
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $299
- Updated
- 2024/03/01
- Product number
- 22477
- Product name
- DM1-SMe
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $638
- Updated
- 2024/03/01
- Product number
- DC11396
- Product name
- DM1-SMe
- Purity
- >98%
- Packaging
- 100mg
- Price
- $750
- Updated
- 2021/12/16
DM1-Sme Chemical Properties,Usage,Production
Uses
DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is the microtubule inhibitor and can be used as the ADC cytotoxin[1].
in vivo
DM1-SMe (15 mg/kg in form of IMGN901, iv, three times a week for 6 weeks) exhibits antitumor efficacy in xenograft mouse models[1].
| Animal Model: | PPTP solid tumor xenograft mouse model[1]. |
| Dosage: | 15 mg/kg in form of IMGN901 |
| Administration: | iv, three times a week for 6 weeks |
| Result: | Inhibited tumor growth. |
IC 50
Maytansinoids
References
[1] Wood AC, et al. Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013;60(11):1860-1867. DOI:10.1002/pbc.24647
[2] Chari RV. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res. 2008;41(1):98-107. DOI:10.1021/ar700108g
DM1-Sme Preparation Products And Raw materials
Raw materials
Preparation Products
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