ChemicalBook > CAS DataBase List > DMT-2'-Fluoro-dG(Ib) Phosphoramidite

DMT-2'-Fluoro-dG(Ib) Phosphoramidite

Product Name
DMT-2'-Fluoro-dG(Ib) Phosphoramidite
CAS No.
144089-97-4
Chemical Name
DMT-2'-Fluoro-dG(Ib) Phosphoramidite
Synonyms
DMT-2'-F-dG(Bz)-CE-Phosphoramidite;2’-F-dG(iBu) Amidite;DMT-2FLUORO-DG(IB) AMIDITE;2'-F-IBu-G Phosphoramidite;ibu-2'-F-dG Phosphoramidite;DMT-2'Fluoro-DG(IB) Amidite;2'-F-iBu-dG-CE-Phosphoramidite;2'-F-dG(iBu)-CE Phosphoramidite;N2-iBu-5'-O-DMT-2'-fluoro-dG-CE;2'-F-dG(iBu)-CE-Phosphoramidite
CBNumber
CB03140864
Molecular Formula
C44H53FN7O8P
Formula Weight
857.91
MOL File
144089-97-4.mol
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DMT-2'-Fluoro-dG(Ib) Phosphoramidite Property

storage temp. 
-20°C
solubility 
DMSO : 100 mg/mL (116.56 mM)
form 
powder
pka
9.16±0.20(Predicted)
color 
white to off-white
InChI
InChI=1/C44H53FN7O8P/c1-10-58-61(52(28(4)5)43(6,7)25-46)60-37-34(59-41(35(37)45)51-26-47-36-38(51)48-42(50-40(36)54)49-39(53)27(2)3)24-57-44(29-14-12-11-13-15-29,30-16-20-32(55-8)21-17-30)31-18-22-33(56-9)23-19-31/h11-23,26-28,34-35,37,41H,10,24H2,1-9H3,(H2,48,49,50,53,54)/t34-,35-,37-,41-,61?/s3
InChIKey
CFFUQMXILRDKMM-QPYLYBSMNA-N
SMILES
C(NC1=NC(=O)C2=C(N1)N([C@H]1[C@H](F)[C@H](OP(OCC)N(C(C)C)C(C#N)(C)C)[C@@H](COC(C3=CC=C(OC)C=C3)(C3=CC=C(OC)C=C3)C3=CC=CC=C3)O1)C=N2)(=O)C(C)C |&1:10,11,13,28,r|
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G211280
Product name
DMT-2′Fluoro-dG(ib) Phosphoramidite
Purity
configured for PerkinElmer, configured for Polygen
Packaging
1G
Price
$164
Updated
2024/03/01
Sigma-Aldrich
Product number
G211200
Product name
DMT-2′Fluoro-dG(ib) Phosphoramidite
Packaging
100g
Price
$8440
Updated
2024/03/01
Sigma-Aldrich
Product number
G211200
Product name
DMT-2′Fluoro-dG(ib) Phosphoramidite
Packaging
500g
Price
$37780
Updated
2024/03/01
Sigma-Aldrich
Product number
G211280
Product name
DMT-2′Fluoro-dG(ib) Phosphoramidite
Purity
configured for PerkinElmer, configured for Polygen
Packaging
2g
Price
$564
Updated
2024/03/01
Sigma-Aldrich
Product number
G211230
Product name
DMT-2′Fluoro-dG(ib) Phosphoramidite
Purity
configured for ABI
Packaging
1g
Price
$284
Updated
2024/03/01
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DMT-2'-Fluoro-dG(Ib) Phosphoramidite Chemical Properties,Usage,Production

Description

DMT-2'-Fluoro-dG(Ib) Phosphoramidite is a 2′Fluoro phosphoramidite that is used to synthesize oligonucleotides that are more thermally stable and provide increased nuclease resistance.

Uses

DMT-2''Fluoro-DG(IB) amidite (CAS# 144089-97-4) is a nucleoside used in the preparation of cyclic dinucleotide compounds, and in the preparation of 4''-C-methoxy-2''-deoxy-2''-fluoro modified ribonucleotides, which improve metabolic stability and elicit efficient RNAi-mediated gene silencing.

Definition

The key features of DMT-2'-Fluoro-dG(Ib) Phosphoramidite include, Can be employed together with DNA or RNA phosphoramidites Recommended deprotection conditions are 8 hours at 55 °C using concentrated ammonia solution, or with AMA for 10 minutes at 65 °C Synthesis of 2′Fluoro oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 3 minutes compared to 90 seconds for DNA monomers) Consistent lot-to-lot high purity and performance Manufactured under a certified ISO 9001 quality system.

DMT-2'-Fluoro-dG(Ib) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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DMT-2'-Fluoro-dG(Ib) Phosphoramidite Suppliers

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View Lastest Price from DMT-2'-Fluoro-dG(Ib) Phosphoramidite manufacturers

Yunbio Tech Co.,Ltd.
Product
DMT-2'-F-dG(iBu)-CE Phosphoramidite 144089-97-4
Price
US $1.00/kg
Min. Order
1kg
Purity
0.98
Supply Ability
100kg
Release date
2023-08-07
SHANGHAI NOVRIBO BIOTECH
Product
2'-F-dG(iBu) CE Phosphoramidite 144089-97-4
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-21
Hefei Huana Biomedical Technology Co.,Ltd.
Product
N2-iBu-5'-O-DMT-2'-fluoro-dG-CE 144089-97-4
Price
US $0.00/mg
Min. Order
100mg
Purity
≥99%
Supply Ability
20tons
Release date
2023-03-09

144089-97-4, DMT-2'-Fluoro-dG(Ib) PhosphoramiditeRelated Search:

p-Anisidine Cinnamyl alcohol

  • 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • DMT-2FLUORO-DG(IB) AMIDITE
  • DMT-2'-F-dG(iBu)-CE Phosphoramidite
  • 2'-F-dG(iBu)-CE Phosphoramidite
  • 5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-Deoxy-guanosine 3'-CE phosphoramidite
  • N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-6-oxo-3H-purin-2-yl]-2-methylpropanamide
  • ibu-2'-F-dG Phosphoramidite
  • 2'-fluoro-N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-deoxyguanosine-3'-CE-Phosphoramidite
  • Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • 5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-Deoxy-guanosine 3'-CE
  • DMT-2'-F-dG(Bz)-CE-Phosphoramidite
  • 2'-DEOXY-2'-FLUORO-N2-IBU-GUANOSINE-3'-CE-PHOSPHORAMIDITE
  • 5'-O-DMT-2'-F-Isobutyryl-Deoxyguanosine-CE Phosphoramidite
  • DMT-2'-F-dG(iBu) Phosphoramidite
  • N2-iBu-5'-O-DMT-2'-fluoro-dG-CE
  • (2S,3R,4R,5R)-2-(2,2-bis(4-methoxyphenyl)-2-phenylethoxy)-4-fluoro-5-(2-isobutyramido-6-oxo-3,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
  • 5'-O-DMT-2'-F-N2-Isobutyryl-2'-Deoxy Guanosine -3’-Cyanoethyl Phosphoramidit
  • DMT-2'-F-dG(iBu)-CE-Phosphoramidite2'-fluoro-N2-isobutyryl-5'-0-(4,4'-dimethoxytrityl)-2'-deoxyguano-sine-3'-CE-Phosphoramidite
  • 2'-Fluoro-N-iBu Guanosine Amidite
  • 5’-O-(4, 4’-Dimethoxytrityl)-2’-fluoro-N2-isobutyryl-2’-deoxyguanosine-3’-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • MMT-2'-F-dG(iBu) CE Phosphoramidite
  • DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite
  • 2’-F-dG(iBu) Amidite
  • 2-Fluoro-2-deoxy Guanosine (n-ibu) CED Phosphoramidite
  • 5'-ODMT-2'-Fluoro-N-iBu Guanosine-3'-OCEPA
  • DMT-2'Fluoro-DG(IB) Amidite
  • 2'-F-IBu-G Phosphoramidite
  • DMT-2'-F-dG(iBu)-CE Phosphoramidite
  • 2'-F-iBu-dG-CE-Phosphoramidite
  • 2'-fluoro-N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine-3'-CE-Phosphoramidite
  • DMT-2'-Fluoro-dG(Ib) Phosphoramidite
  • 2'-F-dG(iBu)-CE-Phosphoramidite
  • 144089-97-4
  • Amidite