Conivaptan impurity

Product Name: Conivaptan impurity
CAS No.: 1129433-63-1
Chemical Name: Conivaptan impurity
Synonyms: Conivaptan-d4;N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl-d4]-[1,1'-biphenyl]-2-carboxamide
CBNumber: CB03144862
Molecular Formula: C32H26N4O2
Formula Weight: 498.59
MOL File: 1129433-63-1.mol

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Conivaptan impurity Property

storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26455
Product name: Conivaptan-d4
Packaging: 500μg
Price: $194
Updated: 2024/03/01

Cayman Chemical

Product number: 26455
Product name: Conivaptan-d4
Packaging: 1mg
Price: $369
Updated: 2024/03/01

AK Scientific

Product number: 3226DC
Product name: 2-Phenyl-N-[2,3,5,6-tetradeuterio-4-(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]benzamide
Packaging: 1mg
Price: $753
Updated: 2021/12/16

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Conivaptan impurity Chemical Properties,Usage,Production

Biological Activity

Conivaptan-d4 is intended for use as an internal standard for the quantification of conivaptan by GC- or LC-MS. Conivaptan is an antagonist of the arginine vasopressin (AVP) receptors V1A and V2 (Kis = 0.48 and 3.04 nM for rat liver V1A and kidney V2, respectively).1 It also competitively inhibits oxytocin binding to rat uterine oxytocin receptors (Ki = 44 nM) but has no effect on AVP binding to anterior pituitary V1B receptors at concentrations up to 100 μM in a radioligand binding assay. Conivaptan suppresses AVP-induced increases in intracellular calcium in vascular smooth muscle cells (VSMCs) in vitro and the pressor response in pithed rats. Conivaptan (0.01-0.3 mg/kg, i.v.) increases urine output and decreases urine osmolality in dehydrated conscious rats in a dose-dependent manner. It also reduces brain edema and blood-brain barrier disruption in a mouse experimental stroke model.2

References

1.Tahara, A., Tomura, Y., Wada, K.-I., et al.Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V1A and V2 receptor antagonist, in vitro and in vivoJ. Pharmacol. Exp. Ther.282(1)301-308(1997) 2.Zeynalov, E., Jones, S.M., Seo, J.W., et al.Arginine-vasopressin receptor blocker conivaptan reduces brain edema and blood-brain barrier disruption after experimental stroke in micePLoS One10(8)e0136121(2015)

Conivaptan impurity Preparation Products And Raw materials

Raw materials

Preparation Products

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Conivaptan impurity Suppliers

China 7 United States 1 Global 8

Pharmacodia (Beijing) Co.,Ltd

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1129433-63-1, Conivaptan impurityRelated Search:

2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine 2-Methyl-5,6-dihydro-4H-benzo[b]oxazolo[5,4-d]azepine 2-Methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine Conivaptan hydrochloride 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid N-(4-(2-Methyl-5,6-dihydro-4H-benzo[b]oxazolo[5,4-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxaMide

Conivaptan-d4

N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl-d4]-[1,1'-biphenyl]-2-carboxamide

1129433-63-1