Conivaptan hydrochloride

Product Name: Conivaptan hydrochloride
CAS No.: 168626-94-6
Chemical Name: Conivaptan hydrochloride
Synonyms: Vaprisol;Conivaptan HCI;Conivaptan HCl;Unii-75L57R6X36;Conivaptan HCl (YM 087);Conivaptan hydrochkoride;Conivaptan hydrochloride;Conivaptan hydrochloride [usan];Conivaptan hydrochloride, >=99%;Conivaptan hydrochloride USP/EP/BP
CBNumber: CB81246922
Molecular Formula: C32H26N4O2.HCl
Formula Weight: 535.04
MOL File: 168626-94-6.mol

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Conivaptan hydrochloride Property

Melting point:: >250°
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1S/C32H26N4O2.ClH/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22;/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37);1H
InChIKey: BTYHAFSDANBVMJ-UHFFFAOYSA-N
SMILES: C12=CC=CC=C1N(CCC1N=C(C)NC2=1)C(=O)C1=CC=C(NC(=O)C2C=CC=CC=2C2=CC=CC=C2)C=C1.Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23728
Product name: Conivaptan (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 23728
Product name: Conivaptan (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 23728
Product name: Conivaptan (hydrochloride)
Purity: ≥95%
Packaging: 25mg
Price: $268
Updated: 2024/03/01

Cayman Chemical

Product number: 23728
Product name: Conivaptan (hydrochloride)
Purity: ≥95%
Packaging: 50mg
Price: $469
Updated: 2024/03/01

Tocris

Product number: 6830
Product name: Conivaptanhydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $214
Updated: 2021/12/16

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Conivaptan hydrochloride Chemical Properties,Usage,Production

Description

Arginine vasopressin is intimately involved in volume homeostasis, and elevated levels of arginine vasopressin are responsible for the pathogenesis and progression of diseases with an imbalance of sodium and water, particularly congestive heart failure. To restore homeostasis, antagonism of vasopressin receptors is a practical solution. As such, conivaptan has been developed and launched as a dual V1a and V2 vasopressin receptor antagonist. As a competitive, reversible inhibitor of both subtypes, conivaptan can modulate systemic vascular resistance through the V1a receptor (Ki ? 0.48 nM) distributed in vascular smooth muscle cells, cardiomyocytes, hepatocytes, and platelets and blocks the renal V2 receptor (Ki ? 3.04 nM) resulting in enhanced diuresis, thereby increasing serum sodium concentration and reducing total body volume. Currently, the drug is approved for the management of refractory hyponatremia and potentially lifethreatening sodium and water imbalance, but it has shown promise as a potential treatment option for other diseases, such as congestive heart failure, syndrome of antidiuretic hormone, diabetes insipidus, and liver cirrhosis.

Description

Conivaptan is an antagonist of the arginine vasopressin (AVP) receptors V_1A and V₂ (K_is = 0.48 and 3.04 nM for rat liver V_1A and kidney V₂, respectively). It also competitively inhibits oxytocin binding to rat uterine oxytocin receptors (K_i = 44 nM) but has no effect on AVP binding to anterior pituitary V_1B receptors at concentrations up to 100 μM in a radioligand binding assay. Conivaptan suppresses AVP-induced increases in intracellular calcium in vascular smooth muscle cells (VSMCs) in vitro and the pressor response in pithed rats. Conivaptan (0.01-0.3 mg/kg, i.v.) increases urine output and decreases urine osmolality in dehydrated conscious rats in a dose-dependent manner. It also reduces brain edema and blood-brain barrier disruption in a mouse experimental stroke model.

Chemical Properties

White to Off-White Solid

Originator

Yamanouchi (Japan)

Uses

Used in treatment of congestive heart failure.

Uses

Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist).

Definition

ChEBI: The hydrochloride salt of conivaptan. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2, and is used for the treatment of hyponatraemia (low blood sodium levels) cau ed by syndrome of inappropriate antidiuretic hormone (SIADH).

brand name

Vaprisol (Astellas).

storage

Desiccate at RT

Conivaptan hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Conivaptan hydrochloride Suppliers

Canada 1 China 163 India 4 United Kingdom 3 United States 16 Global 187

Shanghai Boyle Chemical Co., Ltd.

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J & K SCIENTIFIC LTD.

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Adamas Reagent, Ltd.

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Shanghai Longsheng chemical Co.,Ltd.

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Tongchuang Pharma(Suzhou). Co., Ltd.

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Beijing Comparison Pharmaceutical Technology Co., Ltd

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Email: sales@bjcomparison.com
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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View Lastest Price from Conivaptan hydrochloride manufacturers

shandong perfect biotechnology co.ltd

Product: Conivaptan HCl 168626-94-6
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 100kg
Release date: 2023-08-14

Shaanxi Dideu Medichem Co. Ltd

Product: Conivaptan hydrochloride 168626-94-6
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-11

Henan Aochuang Chemical Co.,Ltd.

Product: Conivaptan hydrochloride 168626-94-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

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Conivaptan HCl

Conivaptan hydrochloride [usan]

Unii-75L57R6X36

Vaprisol

Conivaptan hydrochkoride

N-[4-[(4,5-Dihydro-2-MethyliMidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-Biphenyl]-2-carboxaMide Hydrochloride

Conivaptan HCI

N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide, hydrochloride (1:1)

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Conivaptan hydrochloride, >=99%

Conivaptan hydrochloride

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Conivaptan hydrochloride USP/EP/BP

Conivaptan HCl (YM 087)

Conivaptan HydrochlorideQ: What is Conivaptan Hydrochloride Q: What is the CAS Number of Conivaptan Hydrochloride Q: What is the storage condition of Conivaptan Hydrochloride Q: What are the applications of Conivaptan Hydrochloride

Vaprisol, Conivaptan hydrochloride

N-(4-(2-Methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide hydrochloride

N-[4-({4-methyl-3,5,9-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),2(6),4,10,12-pentaen-9-yl}carbonyl)phenyl]-2-phenylbenzamide hydrochloride

N-(4-(2-Methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide hydrochloride

168626-94-6

C32H26N4O2HCl

C32H27ClN4O2

Inhibitors

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals