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Sitagliptin phosphate monohydrate

Product Name
Sitagliptin phosphate monohydrate
CAS No.
654671-77-9
Chemical Name
Sitagliptin phosphate monohydrate
Synonyms
Sitagliptin phosphate hydrate;Sitagliptin monohydrate;(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate;Sitagliptin Phosphate.H2O;(R)-3-Amino-1-(3-(trifluor;itagliptin phosphate monohydrate;(R)-3-AMino-1-(3-(trifluoroMethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydrate;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)Butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazinephosphatemonohydrate;7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate;D06645
CBNumber
CB11011754
Molecular Formula
C16H18F6N5O5P
Formula Weight
505.31
MOL File
654671-77-9.mol
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Sitagliptin phosphate monohydrate Property

Flash point:
274.3℃
storage temp. 
2-8°C
solubility 
≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥30.6 mg/mL in H2O with ultrasonic
form 
solid
color 
White to off-white
InChI
InChI=1/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)/t9-;/s3
InChIKey
IQFYVLUXQXSJJN-OVMXBOEKNA-N
SMILES
P(O)(O)(O)=O.C(C1=NN=C2CN(C(=O)C[C@H](N)CC3C=C(F)C(F)=CC=3F)CCN12)(F)(F)F |&1:15,r|
CAS DataBase Reference
654671-77-9(CAS DataBase Reference)
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Safety

Risk Statements 
28-38-41-48-62-63
Safety Statements 
24/25-26-28-36/37/39
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1857
Product name
Sitagliptin Phosphate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
1612903
Product name
Sitagliptin phosphate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001812
Product name
Sitagliptin phosphate monohydrate
Purity
EuropePharmacopoeia (EP) Reference Standard
Packaging
y0001812
Price
$220
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
API0000800
Product name
SITAGLIPTIN PHOSPHATE MONOHYDRATE
Purity
95.00%
Packaging
1G
Price
$918.23
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000800
Product name
SITAGLIPTIN PHOSPHATE MONOHYDRATE
Purity
95.00%
Packaging
5G
Price
$2246.48
Updated
2021/12/16
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Sitagliptin phosphate monohydrate Chemical Properties,Usage,Production

Chemical Properties

white crystalline

Uses

antimuscarinic

Uses

Sitagliptin Phosphate Monohydrate is a dipeptidyl peptidase-IV (DPPIV) inhibitor.

Biological Activity

sitagliptin phosphate monohydrate is the phosphate salt of its active component, sitagliptin, with one molecule of water. sitagliptin is a potent inhibitor of dipeptidyl peptidase 4 (dpp-4), an enzyme catalyzing the cleavage of peptides with an n-terminal alanine or proline amino acid residue, that selectively inhibits dpp-4 with 50% inhibition concentration ic50 value of 18 nm and shows no affinity towards other ddp enzymes (such as ddp-8 and ddp-9). the inhibition of dpp4 by sitagliptin has been found to be mediated by increasing levels of two dpp-4 substrates, including glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip). sitagliptin is currently being investigated in the treatment of type ii diabetes.gallwitz b. review of sitagliptin phosphate: a novel treatment for type 2 diabetes. vasc health risk manag. 2007;3(2):203-10.

target

DPP-4

Sitagliptin phosphate monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Sitagliptin phosphate monohydrate Suppliers

Hefei HomeSunshine Pharmaceutical Technology Co., Ltd.
Tel
0551-65523315 17705606359
Fax
0551-65523375
Email
errol@homesunshinepharma.com
Country
China
ProdList
71
Advantage
58
Changzhou Kangte Pharmtech Co.,Ltd
Tel
0519-82813797 18994752886
Fax
0519-82813703
Email
czkangte@hotmail.com
Country
China
ProdList
45
Advantage
62
Ningbo Zhenlei Chemical Co.,ltd.
Tel
0576-88808091 13958565781
Fax
+0576-88203603
Email
shuang.lin@zhenleichem.com
Country
China
ProdList
89
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58
AnHui HaiKang Pharmaceutical Co., Ltd.
Tel
0556-5800026 17709662922
Email
melrose@worldpharma.cn
Country
China
ProdList
247
Advantage
55
Beijing Huikang Boyuan Chemical Tech Co., Ltd
Tel
010-68862197 13810598707
Fax
010-68882204
Email
sales@huikangchem.com
Country
China
ProdList
103
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61
Zhejiang Jiuzhou Pharmaceutical Co., Ltd
Tel
13566413511
Email
le.sun@jiuzhoupharma.com
Country
China
ProdList
31
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58
Tiantai Yisheng Biochemical Technology Co., Ltd
Tel
18958639818微信同号尽量微信不要电话
Email
156697457@qq.com
Country
China
ProdList
117
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
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View Lastest Price from Sitagliptin phosphate monohydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Sitagliptin phosphate monohydrate 654671-77-9
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%-102;USP
Supply Ability
1000KGS
Release date
2021-07-02
S&Y Biochem Co.,Ltd
Product
Sitagliptin phosphate monohydrate 654671-77-9
Price
US $1.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-08-01
Nanjing Fred Technology Co., Ltd
Product
Sitagliptin phosphate monohydrate 654671-77-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%, Single impurity<0.1
Supply Ability
1 ton
Release date
2024-01-02

654671-77-9, Sitagliptin phosphate monohydrateRelated Search:


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