Sitagliptin phosphate monohydrate
- Product Name
- Sitagliptin phosphate monohydrate
- CAS No.
- 654671-77-9
- Chemical Name
- Sitagliptin phosphate monohydrate
- Synonyms
- Sitagliptin phosphate hydrate;Sitagliptin monohydrate;(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate;Sitagliptin Phosphate.H2O;(R)-3-Amino-1-(3-(trifluor;itagliptin phosphate monohydrate;(R)-3-AMino-1-(3-(trifluoroMethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydrate;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)Butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazinephosphatemonohydrate;7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate;D06645
- CBNumber
- CB11011754
- Molecular Formula
- C16H18F6N5O5P
- Formula Weight
- 505.31
- MOL File
- 654671-77-9.mol
Sitagliptin phosphate monohydrate Property
- Flash point:
- 274.3℃
- storage temp.
- 2-8°C
- solubility
- ≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥30.6 mg/mL in H2O with ultrasonic
- form
- solid
- color
- White to off-white
- InChI
- InChI=1/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)/t9-;/s3
- InChIKey
- IQFYVLUXQXSJJN-OVMXBOEKNA-N
- SMILES
- P(O)(O)(O)=O.C(C1=NN=C2CN(C(=O)C[C@H](N)CC3C=C(F)C(F)=CC=3F)CCN12)(F)(F)F |&1:15,r|
- CAS DataBase Reference
- 654671-77-9(CAS DataBase Reference)
Safety
- Risk Statements
- 28-38-41-48-62-63
- Safety Statements
- 24/25-26-28-36/37/39
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314Get medical advice/attention if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- PHR1857
- Product name
- Sitagliptin Phosphate
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 1g
- Price
- $173
- Updated
- 2024/03/01
- Product number
- 1612903
- Product name
- Sitagliptin phosphate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- Y0001812
- Product name
- Sitagliptin phosphate monohydrate
- Purity
- EuropePharmacopoeia (EP) Reference Standard
- Packaging
- y0001812
- Price
- $220
- Updated
- 2024/03/01
- Product number
- A4036
- Product name
- Sitagliptin phosphate monohydrate
- Packaging
- 1unit
- Price
- $28
- Updated
- 2021/12/16
- Product number
- X0051
- Product name
- Sitagliptin phosphate monohydrate
- Packaging
- 100mg
- Price
- $37
- Updated
- 2021/12/16
Sitagliptin phosphate monohydrate Chemical Properties,Usage,Production
Chemical Properties
white crystalline
Uses
antimuscarinic
Uses
Sitagliptin Phosphate Monohydrate is a dipeptidyl peptidase-IV (DPPIV) inhibitor.
Biological Activity
sitagliptin phosphate monohydrate is the phosphate salt of its active component, sitagliptin, with one molecule of water. sitagliptin is a potent inhibitor of dipeptidyl peptidase 4 (dpp-4), an enzyme catalyzing the cleavage of peptides with an n-terminal alanine or proline amino acid residue, that selectively inhibits dpp-4 with 50% inhibition concentration ic50 value of 18 nm and shows no affinity towards other ddp enzymes (such as ddp-8 and ddp-9). the inhibition of dpp4 by sitagliptin has been found to be mediated by increasing levels of two dpp-4 substrates, including glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip). sitagliptin is currently being investigated in the treatment of type ii diabetes.gallwitz b. review of sitagliptin phosphate: a novel treatment for type 2 diabetes. vasc health risk manag. 2007;3(2):203-10.
target
DPP-4
Sitagliptin phosphate monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Sitagliptin phosphate monohydrate manufacturers
- Product
- Sitagliptin Phosphate Monohydrate 654671-77-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-09-05
- Product
- Sitagliptin phosphate monohydrate 654671-77-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-08-01
- Product
- Sitagliptin phosphate monohydrate 654671-77-9
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%-102;USP
- Supply Ability
- 1000KGS
- Release date
- 2021-07-02