ChemicalBook > CAS DataBase List > Sitagliptin phosphate monohydrate
Sitagliptin phosphate monohydrate
- Product Name
- Sitagliptin phosphate monohydrate
- CAS No.
- 654671-77-9
- Chemical Name
- Sitagliptin phosphate monohydrate
- Synonyms
- Sitagliptin phosphate hydrate;Sitagliptin monohydrate;(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate;Sitagliptin Phosphate.H2O;(R)-3-Amino-1-(3-(trifluor;itagliptin phosphate monohydrate;(R)-3-AMino-1-(3-(trifluoroMethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydrate;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)Butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazinephosphatemonohydrate;7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate;D06645
- CBNumber
- CB11011754
- Molecular Formula
- C16H18F6N5O5P
- Formula Weight
- 505.31
- MOL File
- 654671-77-9.mol
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Sitagliptin phosphate monohydrate Property
- Flash point:
- 274.3℃
- storage temp.
- 2-8°C
- solubility
- ≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥30.6 mg/mL in H2O with ultrasonic
- form
- solid
- CAS DataBase Reference
- 654671-77-9(CAS DataBase Reference)
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Safety
- Risk Statements
- 28-38-41-48-62-63
- Safety Statements
- 24/25-26-28-36/37/39
- HS Code
- 29335990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314Get medical advice/attention if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- PHR1857
- Product name
- Sitagliptin Phosphate
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 1g
- Price
- $173
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 1612903
- Product name
- Sitagliptin phosphate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- Y0001812
- Product name
- Sitagliptin phosphate monohydrate
- Purity
- EuropePharmacopoeia (EP) Reference Standard
- Packaging
- y0001812
- Price
- $220
- Updated
- 2024/03/01
American Custom Chemicals Corporation
- Product number
- API0000800
- Product name
- SITAGLIPTIN PHOSPHATE MONOHYDRATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $918.23
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0000800
- Product name
- SITAGLIPTIN PHOSPHATE MONOHYDRATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2246.48
- Updated
- 2021/12/16
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Sitagliptin phosphate monohydrate Chemical Properties,Usage,Production
Chemical Properties
white crystalline
Uses
antimuscarinic
Uses
Sitagliptin Phosphate Monohydrate is a dipeptidyl peptidase-IV (DPPIV) inhibitor.
Biological Activity
sitagliptin phosphate monohydrate is the phosphate salt of its active component, sitagliptin, with one molecule of water. sitagliptin is a potent inhibitor of dipeptidyl peptidase 4 (dpp-4), an enzyme catalyzing the cleavage of peptides with an n-terminal alanine or proline amino acid residue, that selectively inhibits dpp-4 with 50% inhibition concentration ic50 value of 18 nm and shows no affinity towards other ddp enzymes (such as ddp-8 and ddp-9). the inhibition of dpp4 by sitagliptin has been found to be mediated by increasing levels of two dpp-4 substrates, including glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip). sitagliptin is currently being investigated in the treatment of type ii diabetes.gallwitz b. review of sitagliptin phosphate: a novel treatment for type 2 diabetes. vasc health risk manag. 2007;3(2):203-10.
target
DPP-4
Sitagliptin phosphate monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Sitagliptin phosphate monohydrate manufacturers
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
- Product
- Sitagliptin phosphate monohydrate 654671-77-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98% HPLC
- Supply Ability
- 1000 kgs
- Release date
- 2024-05-15
Chongqing Zhihe Biopharmaceutical Co., Ltd.
- Product
- Sitagliptin phosphate monohydrate 654671-77-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 99
- Supply Ability
- 20tons
- Release date
- 2024-02-06
Nanjing Fred Technology Co., Ltd
- Product
- Sitagliptin phosphate monohydrate 654671-77-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%, Single impurity＜0.1
- Supply Ability
- 1 ton
- Release date
- 2024-01-02
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