Vemakalant
Pharmacological action- Product Name
- Vemakalant
- CAS No.
- 794466-70-9
- Chemical Name
- Vemakalant
- Synonyms
- CS-419;Vemakalant;Vernakalant;Vemakalant USP/EP/BP;Vernakalant (RSD-1235);VERNAKALANT;RSD1235;RSD 1235;RSD-1235;Vernakalant Impurity B ((3S, 1'R, 2'R)-Isomer);(3R)-1-[(1R,2R)-2-[2-(3,4-Dimethoxyphenyl)ethoxy]cyclohexyl]-3-pyrrolidinol;(3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol;3-Pyrrolidinol, 1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-, (3R)-
- CBNumber
- CB02498847
- Molecular Formula
- C20H31NO4
- Formula Weight
- 349.46
- MOL File
- 794466-70-9.mol
Vemakalant Property
- Boiling point:
- 479.0±45.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO
- form
- Powder
- pka
- 14.79±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- API0014187
- Product name
- VERNAKALANT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.37
- Updated
- 2021/12/16
- Product number
- API0014187
- Product name
- VERNAKALANT
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $649.95
- Updated
- 2021/12/16
- Product number
- CD31000781
- Product name
- Vernakalant
- Purity
- 98+%
- Packaging
- 50mg
- Price
- $1124
- Updated
- 2021/12/16
- Product number
- CD31000781
- Product name
- Vernakalant
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $375
- Updated
- 2021/12/16
Vemakalant Chemical Properties,Usage,Production
Pharmacological action
Venakaran works by blocking peak sodium currents by blocking overdrive-activated delayed rectifier currents (IKur). IKur, encoded by the Kv1.5 channel protein, is abundantly expressed in atrial myocytes, is the main current mediating atrial repolarization in humans, and is activated during atrial fibrillation. Venakalan inhibition of IKur can prolong the action potential duration of the atrium, thereby prolonging the atrial effective refractory period and slowing down atrial conduction, so as to shorten the time of atrial fibrillation and quickly achieve the effect of atrial fibrillation conversion.
Description
Vernakalant is a potassium channel blocker that was approved in Europe in 2010 for treatment of atrial fibrillation (AF), a condition of cardiac arrhythmia in which the atria of the heart beat irregularly due to changes in cardiac ion channel function and distribution. Vernakalant has activity for cardiac Na+ and K+ channels and also for the atrial-selective Kv1.5 channel. Vernakalant (RSD1235) was characterized in animal models to assess efficacy, atrial selectivity, and reduction in side effects.
Originator
Cardiome Pharma Corp. (Canada)
Definition
ChEBI: Vernakalant is an alcohol and a member of phenols.
brand name
Brinavess
Vemakalant Preparation Products And Raw materials
Raw materials
Preparation Products
Vemakalant Suppliers
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View Lastest Price from Vemakalant manufacturers
- Product
- Vemakalant 794466-70-9
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- Vernakalant 794466-70-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Vernakalant 794466-70-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09