Vemakalant

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Pharmacological action

Product Name: Vemakalant
CAS No.: 794466-70-9
Chemical Name: Vemakalant
Synonyms: CS-419;Vemakalant;Vernakalant;Vemakalant USP/EP/BP;Vernakalant (RSD-1235);VERNAKALANT;RSD1235;RSD 1235;RSD-1235;Vernakalant Impurity B ((3S, 1'R, 2'R)-Isomer);(3R)-1-[(1R,2R)-2-[2-(3,4-Dimethoxyphenyl)ethoxy]cyclohexyl]-3-pyrrolidinol;(3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol;3-Pyrrolidinol, 1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-, (3R)-
CBNumber: CB02498847
Molecular Formula: C20H31NO4
Formula Weight: 349.46
MOL File: 794466-70-9.mol

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Vemakalant Property

Boiling point:: 479.0±45.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO
form: Powder
pka: 14.79±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0014187
Product name: VERNAKALANT
Purity: 95.00%
Packaging: 5MG
Price: $495.37
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0014187
Product name: VERNAKALANT
Purity: 95.00%
Packaging: 10MG
Price: $649.95
Updated: 2021/12/16

Crysdot

Product number: CD31000781
Product name: Vernakalant
Purity: 98+%
Packaging: 50mg
Price: $1124
Updated: 2021/12/16

Crysdot

Product number: CD31000781
Product name: Vernakalant
Purity: 98+%
Packaging: 10mg
Price: $375
Updated: 2021/12/16

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Vemakalant Chemical Properties,Usage,Production

Pharmacological action

Venakaran works by blocking peak sodium currents by blocking overdrive-activated delayed rectifier currents (IKur). IKur, encoded by the Kv1.5 channel protein, is abundantly expressed in atrial myocytes, is the main current mediating atrial repolarization in humans, and is activated during atrial fibrillation. Venakalan inhibition of IKur can prolong the action potential duration of the atrium, thereby prolonging the atrial effective refractory period and slowing down atrial conduction, so as to shorten the time of atrial fibrillation and quickly achieve the effect of atrial fibrillation conversion.

Description

Vernakalant is a potassium channel blocker that was approved in Europe in 2010 for treatment of atrial fibrillation (AF), a condition of cardiac arrhythmia in which the atria of the heart beat irregularly due to changes in cardiac ion channel function and distribution. Vernakalant has activity for cardiac Na+ and K+ channels and also for the atrial-selective Kv1.5 channel. Vernakalant (RSD1235) was characterized in animal models to assess efficacy, atrial selectivity, and reduction in side effects.

Originator

Cardiome Pharma Corp. (Canada)

Definition

ChEBI: Vernakalant is an alcohol and a member of phenols.

brand name

Brinavess

Vemakalant Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Vemakalant manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Vemakalant 794466-70-9
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: Vernakalant 794466-70-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Vernakalant 794466-70-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

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Vemakalant

Vernakalant

Vernakalant Impurity B ((3S, 1'R, 2'R)-Isomer)

CS-419

(3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol

VERNAKALANT;RSD1235;RSD 1235;RSD-1235

(3R)-1-[(1R,2R)-2-[2-(3,4-Dimethoxyphenyl)ethoxy]cyclohexyl]-3-pyrrolidinol

3-Pyrrolidinol, 1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-, (3R)-

Vemakalant USP/EP/BP

Vernakalant (RSD-1235)

794466-70-9