CP 94253 hydrochloride
- Product Name
- CP 94253 hydrochloride
- CAS No.
- 845861-39-4
- Chemical Name
- CP 94253 hydrochloride
- Synonyms
- CP 94253 dihydrochloride, 5-HT1B agonist;1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-,monohydrochloride;CP94253,CP94253 hydrochloride,Serotonin Receptor,inhibit,CP 94253,CP-94253,5-hydroxytryptamine Receptor,Inhibitor,5-HT Receptor
- CBNumber
- CB03146275
- Molecular Formula
- C15H20ClN3O
- Formula Weight
- 293.8
- MOL File
- 845861-39-4.mol
CP 94253 hydrochloride Property
- storage temp.
- Desiccate at RT
- solubility
- Soluble to 25 mM in water and to 100 mM in DMSO
- form
- Powder
- color
- Pale yellow
N-Bromosuccinimide Price
- Product number
- 29486
- Product name
- CP 94,253 (hydrochloride)
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 29486
- Product name
- CP 94,253 (hydrochloride)
- Packaging
- 25mg
- Price
- $336
- Updated
- 2024/03/01
- Product number
- 29486
- Product name
- CP 94,253 (hydrochloride)
- Packaging
- 10mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- P398983
- Product name
- CP94253Hydrochloride
- Packaging
- 5mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- B6685
- Product name
- CP94253hydrochloride
- Packaging
- 10mg
- Price
- $308
- Updated
- 2021/12/16
CP 94253 hydrochloride Chemical Properties,Usage,Production
Description
CP 94,253 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B (Ki = 2 nM in a radioligand binding assay). It is selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1C, and 5-HT2 receptors (Kis = 89, 49, 860, and 1,600 nM, respectively). CP 94,253 (10 and 17 mg/kg) reduces aggressive behavior in a resident-intruder test in mice, as well as decreases alcohol-induced aggression in mice with an ED50 value of 3.8 mg/kg. It decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, when administered at a dose of 5 mg/kg. CP 94,253 (2.5 mg/kg) also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.
Uses
CP 94253 Hydrochloride is a potent and selective serotonin 5-HT1B receptor agonist with anticonvulsant activity.
storage
Desiccate at RT
CP 94253 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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