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CP 94253 hydrochloride

Product Name
CP 94253 hydrochloride
CAS No.
845861-39-4
Chemical Name
CP 94253 hydrochloride
Synonyms
CP94253 hydrochloride, 10 mM in DMSO;CP 94253 dihydrochloride, 5-HT1B agonist;1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-,monohydrochloride;CP94253,CP94253 hydrochloride,Serotonin Receptor,inhibit,CP 94253,CP-94253,5-hydroxytryptamine Receptor,Inhibitor,5-HT Receptor
CBNumber
CB03146275
Molecular Formula
C15H20ClN3O
Formula Weight
293.8
MOL File
845861-39-4.mol
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CP 94253 hydrochloride Property

storage temp. 
Desiccate at RT
solubility 
Soluble to 25 mM in water and to 100 mM in DMSO
form 
Powder
color 
Pale yellow
InChI
InChI=1S/C15H19N3O.ClH/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11;/h3-5,10,16-17H,2,6-9H2,1H3;1H
InChIKey
PIIOXKQIZCVXMD-UHFFFAOYSA-N
SMILES
O(C1=CC=C2NC=C(C3=CCNCC3)C2=N1)CCC.Cl
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29486
Product name
CP 94,253 (hydrochloride)
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
29486
Product name
CP 94,253 (hydrochloride)
Packaging
25mg
Price
$336
Updated
2024/03/01
Cayman Chemical
Product number
29486
Product name
CP 94,253 (hydrochloride)
Packaging
10mg
Price
$152
Updated
2024/03/01
TRC
Product number
P398983
Product name
CP94253Hydrochloride
Packaging
5mg
Price
$210
Updated
2021/12/16
ApexBio Technology
Product number
B6685
Product name
CP94253hydrochloride
Packaging
10mg
Price
$308
Updated
2021/12/16
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CP 94253 hydrochloride Chemical Properties,Usage,Production

Description

CP 94,253 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B (Ki = 2 nM in a radioligand binding assay). It is selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1C, and 5-HT2 receptors (Kis = 89, 49, 860, and 1,600 nM, respectively). CP 94,253 (10 and 17 mg/kg) reduces aggressive behavior in a resident-intruder test in mice, as well as decreases alcohol-induced aggression in mice with an ED50 value of 3.8 mg/kg. It decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, when administered at a dose of 5 mg/kg. CP 94,253 (2.5 mg/kg) also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.

Uses

CP 94253 Hydrochloride is a potent and selective serotonin 5-HT1B receptor agonist with anticonvulsant activity.

storage

Desiccate at RT

References

[1] DR. B. KENNETH KOE. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253[J]. Drug Development Research, 1992, 26 3: 241-250. DOI: 10.1002/ddr.430260305
[2] E W FISH  K A M  S Faccidomo. Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253.[J]. Psychopharmacology, 1999, 146 4: 391-399. DOI: 10.1007/pl00005484
[3] EWA TATARCZYSKA. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: A possible mechanism of action[J]. European journal of pharmacology, 2005, 516 1: Pages 46-50. DOI: 10.1016/j.ejphar.2005.04.025
[4] EWA CHOJNACKA-WóJCIK  Ewa T  Aleksandra Kodzińska. The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action[J]. Journal of Pharmacy and Pharmacology, 2010, 57 2: 253-257. DOI: 10.1211/0022357055399

CP 94253 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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CP 94253 hydrochloride Suppliers

China 34 United Kingdom 1 United States 5 USA 1 Global 41
Anqing YanZhi Pharma Discovery Co.,Ltd.
Tel
18055651951
Email
2272561977@qq.com
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China
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436
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Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
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China
ProdList
9548
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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4827
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
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60
Chuzhou KeMail Chemical Technology Co., Ltd
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0550-5196001 15000891977
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0550-5196001
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wj520wjxby@126.com
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China
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1946
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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32467
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58
Finetech Industry Limited
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+86-27-8746-5837 +8619945049750
Fax
86 27 87772287
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info@finetechnology-ind.com
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China
ProdList
9541
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58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471;
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sales@sarms4muscle.com
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China
ProdList
10473
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58
ShenZhen Davoos Tech Ltd
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0752-5555973 13923768523
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95372103@qq.com
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China
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670
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845861-39-4, CP 94253 hydrochlorideRelated Search:


  • 1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-,monohydrochloride
  • CP94253,CP94253 hydrochloride,Serotonin Receptor,inhibit,CP 94253,CP-94253,5-hydroxytryptamine Receptor,Inhibitor,5-HT Receptor
  • CP 94253 dihydrochloride, 5-HT1B agonist
  • CP94253 hydrochloride, 10 mM in DMSO
  • 845861-39-4