LDN 193189 hydrochloride

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LDN 193189 hydrochloride

Product Name: LDN 193189 hydrochloride
CAS No.: 1435934-00-1
Chemical Name: LDN 193189 hydrochloride
Synonyms: DM-3189 2HCl;LDN-193189 2HC;LDN-193189 2HCl;LDN-193189 (DM3189) 2HCl;LDN 193189 dihydrochloride;LDN-193189 2HCl|||DM-3189 2HCl;Viomycin LDN 193189 Dihydrochloride;4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride;4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline dihydrochloride
CBNumber: CB03146321
Molecular Formula: C25H24Cl2N6
Formula Weight: 479.40426
MOL File: 1435934-00-1.mol

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LDN 193189 hydrochloride Property

storage temp.: -20°C
solubility: Soluble in DMSO or in Water (up to 5 mg/ml)
form: solid
color: Orange-yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19396
Product name: LDN-193189 (hydrochloride)
Packaging: 5mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 19396
Product name: LDN-193189 (hydrochloride)
Packaging: 25mg
Price: $219
Updated: 2024/03/01

Cayman Chemical

Product number: 19396
Product name: LDN-193189 (hydrochloride)
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 19396
Product name: LDN-193189 (hydrochloride)
Packaging: 10mg
Price: $100
Updated: 2024/03/01

Tocris

Product number: 6053
Product name: LDN193189dihydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $216
Updated: 2021/12/16

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LDN 193189 hydrochloride Chemical Properties,Usage,Production

Description

LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC₅₀ value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC₅₀s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC₅₀s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

storage

-20°C

References

1) Yu?et al.?(2008),?BMP type 1 receptor inhibition reduces heterotropic ossification; Nature Med.,14?1363 2) Chambers?et al.?(2012),?Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors; Nature Biotechnol.?30?715 3) Kreitzer?et al. (2013)?A robust method to derive functional neural crest cells from human pluripotent stem cells; Am. J. Stem Cells,?2?119 4) Lee?et al.?(2011)?BMP4 promotes prostate tumor growth in bone through osteogenesis; Cancer Res.?71?5194

LDN 193189 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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