Z-FY-CHO

Product Name: Z-FY-CHO
CAS No.: 167498-29-5
Chemical Name: Z-FY-CHO
Synonyms: Z-FY-CHO;Z-Phe-Tyr-al;Z-PHE-TYR-CHO;Z-PHE-TYR-ALDEHYDE;Z-L-PHE-L-TYR-ALDEHYDE;CATHEPSIN L INHIBITOR II;Cathepsin L inhibitor inhibitor;(N-Cbz-L-phenylalanyl)-L-tyrosinal;Carbamic acid, N-[(1S)-2-[[(1S)-1-formyl-2-(4-hydroxyphenyl)ethyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester
CBNumber: CB7776924
Molecular Formula: C26H26N2O5
Formula Weight: 446.49
MOL File: 167498-29-5.mol

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Z-FY-CHO Property

Boiling point:: 726.5±60.0 °C(Predicted)
Density: 1.249±0.06 g/cm3(Predicted)
storage temp.: -15°C
solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml)
pka: 9.87±0.15(Predicted)
form: solid
color: Off-white to pale yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219426
Product name: Cathepsin L Inhibitor II
Purity: The Cathepsin L Inhibitor II controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Packaging: 5MG
Price: $116
Updated: 2025/07/31

Cayman Chemical

Product number: 23249
Product name: Cathepsin L Inhibitor
Purity: ≥95%
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 23249
Product name: Cathepsin L Inhibitor
Purity: ≥95%
Packaging: 5mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 23249
Product name: Cathepsin L Inhibitor
Purity: ≥95%
Packaging: 10mg
Price: $197
Updated: 2024/03/01

Cayman Chemical

Product number: 23249
Product name: Cathepsin L Inhibitor
Purity: ≥95%
Packaging: 25mg
Price: $456
Updated: 2024/03/01

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Z-FY-CHO Chemical Properties,Usage,Production

Description

Z-Phe-Tyr-CHO (167498-29-5) is a potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over ?cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic ?pit formation at 1.5 nM and markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption.2 Also inhibits cathepsin K (Kis=0.052 and 1.57 nM for cat L and cat K respectively) and partially provides the basis for the finding that cathepsin K is the protease responsible for osteoclastic bone resorption.3 Provides partial protection against serum and potassium deprivation-induced neuronal death.4 Active in vivo.2

Uses

Z-Phe-Tyr-aldehyde is a cathepsin L inhibitor useful in the study of human osteoclast resorption and drug development for the treatment of coronavirus disease.

in vivo

Intraperitoneal administration of Z-FY-CHO (2.5-10 mg/kg) for 4 weeks suppresses bone weight loss dose dependently in the ovariectomized mouse, experimental model of osteoporosis. Z-FY-CHO acts as a bone resorption suppressor through the inhibition of collagen degradation^[3].

IC 50

cathepsin L

References

[1] JE-TAE WOO. Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L[J]. Bioorganic & Medicinal Chemistry Letters, 1995, 5 14: Pages 1501-1504. DOI:10.1016/0960-894x(95)00236-m
[2] JE-TAE WOO . Suppressive effect of N-(benzyloxycarbonyl)-l-phenylalanyl-l-tyrosinal on bone resorption in vitro and in vivo[J]. European journal of pharmacology, 1996, 300 1: Pages 131-135. DOI:10.1016/0014-2999(95)00858-6
[3] I E JAMES. Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro.[J]. The Journal of Biological Chemistry, 2001, 276 15: 11507-11511. DOI:10.1074/jbc.m010684200
[4] ALLEN KAASIK. Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium[J]. European Journal of Neuroscience, 2005, 22 5: 1023-1031. DOI:10.1111/j.1460-9568.2005.04279.x

Z-FY-CHO Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-FY-CHO Suppliers

China 48 Switzerland 1 United Kingdom 1 United States 6 Global 56

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
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Chemsky (shanghai) International Co.,Ltd

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BOC Sciences

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Shanghai GL Peptide Ltd.

Tel: +86-21-61263340; 17609490614 13764994101
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Kanghua (Shanghai) New Drug Development Co., Ltd.

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Nanjing Meihao Pharmaceutical Technology Co., Ltd.

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Shanghai Jifeng Biotechnology Co., Ltd.

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GL Biochem (Shanghai) Ltd.

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Binhai gill polypeptide co. LTD

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167498-29-5, Z-FY-CHORelated Search:

HARMINE HYDROCHLORIDE Disodium clodronate tetrahydrate BISPHENOL A DIGLYCIDYL ETHER RESIN SALUBRINAL Z-PHE-TYR-OH BENZYLOXYCARBONYL-L-PHENYLALANYL-L-TYROSYL-L-LEUCINE Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE Z-FY-CHO Z-TYR-TYR-OH CATHEPSIN L INHIBITOR V

CATHEPSIN L INHIBITOR II

Z-Phe-Tyr-al

Z-PHE-TYR-ALDEHYDE

Z-PHE-TYR-CHO

Z-FY-CHO

Carbamic acid, N-[(1S)-2-[[(1S)-1-formyl-2-(4-hydroxyphenyl)ethyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester

Z-L-PHE-L-TYR-ALDEHYDE

Cathepsin L inhibitor inhibitor

(N-Cbz-L-phenylalanyl)-L-tyrosinal

167498-29-5