Z-FY-CHO
- Product Name
- Z-FY-CHO
- CAS No.
- 167498-29-5
- Chemical Name
- Z-FY-CHO
- Synonyms
- Z-FY-CHO;Z-Phe-Tyr-al;Z-PHE-TYR-CHO;Z-PHE-TYR-ALDEHYDE;Z-L-PHE-L-TYR-ALDEHYDE;CATHEPSIN L INHIBITOR II;Cathepsin L inhibitor inhibitor;(N-Cbz-L-phenylalanyl)-L-tyrosinal;Carbamic acid, N-[(1S)-2-[[(1S)-1-formyl-2-(4-hydroxyphenyl)ethyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester
- CBNumber
- CB7776924
- Molecular Formula
- C26H26N2O5
- Formula Weight
- 446.49
- MOL File
- 167498-29-5.mol
Z-FY-CHO Property
- Boiling point:
- 726.5±60.0 °C(Predicted)
- Density
- 1.249±0.06 g/cm3(Predicted)
- storage temp.
- -15°C
- solubility
- Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml)
- pka
- 9.87±0.15(Predicted)
- form
- solid
- color
- Off-white to pale yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety
- WGK Germany
- WGK 1
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 219426
- Product name
- Cathepsin L Inhibitor II
- Purity
- The Cathepsin L Inhibitor II controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
- Packaging
- 5MG
- Price
- $124
- Updated
- 2026/03/19
- Product number
- 23249
- Product name
- Cathepsin L Inhibitor
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- 23249
- Product name
- Cathepsin L Inhibitor
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 23249
- Product name
- Cathepsin L Inhibitor
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $197
- Updated
- 2024/03/01
- Product number
- 23249
- Product name
- Cathepsin L Inhibitor
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $456
- Updated
- 2024/03/01
Z-FY-CHO Chemical Properties,Usage,Production
Description
Z-Phe-Tyr-CHO (167498-29-5) is a potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic pit formation at 1.5 nM and markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption.2 Also inhibits cathepsin K (Kis=0.052 and 1.57 nM for cat L and cat K respectively) and partially provides the basis for the finding that cathepsin K is the protease responsible for osteoclastic bone resorption.3 Provides partial protection against serum and potassium deprivation-induced neuronal death.4 Active in vivo.2
Uses
Z-Phe-Tyr-aldehyde is a cathepsin L inhibitor useful in the study of human osteoclast resorption and drug development for the treatment of coronavirus disease.
in vivo
Intraperitoneal administration of Z-FY-CHO (2.5-10 mg/kg) for 4 weeks suppresses bone weight loss dose dependently in the ovariectomized mouse, experimental model of osteoporosis. Z-FY-CHO acts as a bone resorption suppressor through the inhibition of collagen degradation[3].
IC 50
cathepsin L
References
[1] JE-TAE WOO. Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L[J]. Bioorganic & Medicinal Chemistry Letters, 1995, 5 14: Pages 1501-1504. DOI:10.1016/0960-894x(95)00236-m
[2] JE-TAE WOO . Suppressive effect of N-(benzyloxycarbonyl)-l-phenylalanyl-l-tyrosinal on bone resorption in vitro and in vivo[J]. European journal of pharmacology, 1996, 300 1: Pages 131-135. DOI:10.1016/0014-2999(95)00858-6
[3] I E JAMES. Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro.[J]. The Journal of Biological Chemistry, 2001, 276 15: 11507-11511. DOI:10.1074/jbc.m010684200
[4] ALLEN KAASIK. Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium[J]. European Journal of Neuroscience, 2005, 22 5: 1023-1031. DOI:10.1111/j.1460-9568.2005.04279.x
Z-FY-CHO Preparation Products And Raw materials
Raw materials
Preparation Products
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