Z-FY-CHO

Product Name: Z-FY-CHO
CAS No.: 167498-29-5
Chemical Name: Z-FY-CHO
Synonyms: Z-FY-CHO;Z-Phe-Tyr-al;Z-PHE-TYR-CHO;Z-PHE-TYR-ALDEHYDE;Z-L-PHE-L-TYR-ALDEHYDE;CATHEPSIN L INHIBITOR II;Cathepsin L inhibitor inhibitor;Carbamic acid, N-[(1S)-2-[[(1S)-1-formyl-2-(4-hydroxyphenyl)ethyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester
CBNumber: CB7776924
Molecular Formula: C26H26N2O5
Formula Weight: 446.49
MOL File: 167498-29-5.mol

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Z-FY-CHO Property

Boiling point:: 726.5±60.0 °C(Predicted)
Density: 1.249±0.06 g/cm3(Predicted)
storage temp.: -15°C
solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml)
pka: 9.87±0.15(Predicted)
form: solid
color: Off-white to pale yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219426
Product name: Cathepsin L Inhibitor II
Purity: The Cathepsin L Inhibitor II controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Packaging: 5MG
Price: $113
Updated: 2024/03/01

Cayman Chemical

Product number: 23249
Product name: Cathepsin L Inhibitor
Purity: ≥95%
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 23249
Product name: Cathepsin L Inhibitor
Purity: ≥95%
Packaging: 5mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 23249
Product name: Cathepsin L Inhibitor
Purity: ≥95%
Packaging: 10mg
Price: $197
Updated: 2024/03/01

Cayman Chemical

Product number: 23249
Product name: Cathepsin L Inhibitor
Purity: ≥95%
Packaging: 25mg
Price: $456
Updated: 2024/03/01

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Z-FY-CHO Chemical Properties,Usage,Production

Description

Z-Phe-Tyr-CHO (167498-29-5) is a potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over ?cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic ?pit formation at 1.5 nM and markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption.2 Also inhibits cathepsin K (Kis=0.052 and 1.57 nM for cat L and cat K respectively) and partially provides the basis for the finding that cathepsin K is the protease responsible for osteoclastic bone resorption.3 Provides partial protection against serum and potassium deprivation-induced neuronal death.4 Active in vivo.2

Uses

Z-Phe-Tyr-aldehyde is a cathepsin L inhibitor useful in the study of human osteoclast resorption and drug development for the treatment of coronavirus disease.

References

1) Woo et al. (1995), Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L; Bioorg. Med. Chem. Lett., 5 1501 2) Woo et al. (1996), Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo; Eur. J. Pharmacol., 300 131 3) James et al. (2001) Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resoption in vitro; J. Biol. Chem., 276 11507 4) Kaasik et al. (2005), Up regulation if lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium; Eur. J. Neurosci., 22 1023

Z-FY-CHO Preparation Products And Raw materials

Raw materials

Preparation Products

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167498-29-5, Z-FY-CHORelated Search:

HARMINE HYDROCHLORIDE Disodium clodronate tetrahydrate BISPHENOL A DIGLYCIDYL ETHER RESIN SALUBRINAL Z-PHE-TYR-OH BENZYLOXYCARBONYL-L-PHENYLALANYL-L-TYROSYL-L-LEUCINE Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE Z-FY-CHO Z-TYR-TYR-OH CATHEPSIN L INHIBITOR V

CATHEPSIN L INHIBITOR II

Z-Phe-Tyr-al

Z-PHE-TYR-ALDEHYDE

Z-PHE-TYR-CHO

Z-FY-CHO

Carbamic acid, N-[(1S)-2-[[(1S)-1-formyl-2-(4-hydroxyphenyl)ethyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester

Z-L-PHE-L-TYR-ALDEHYDE

Cathepsin L inhibitor inhibitor

167498-29-5