ARM1
- Product Name
- ARM1
- CAS No.
- 68729-05-5
- Chemical Name
- ARM1
- Synonyms
- ARM1;ARM-1 (ARM1);4-(4-Benzylphenyl)-1,3-thiazol-2-amine;2-Thiazolamine, 4-[4-(phenylmethyl)phenyl]-;Epoxide Hydrolase,ARM1,HCT-116 cells,Inhibitor,LTA4H,ARM-1,cytotoxic,positive control,Aminopeptidase,4BSA,inhibit,ARM 1
- CBNumber
- CB03152553
- Molecular Formula
- C16H14N2S
- Formula Weight
- 266.36
- MOL File
- 68729-05-5.mol
ARM1 Property
- storage temp.
- Store at -20°C
- solubility
- ≤1mg/ml in ethanol;10mg/ml in DMSO;15mg/ml in dimethyl formamide
- form
- crystalline solid
N-Bromosuccinimide Price
- Product number
- 15865
- Product name
- ARM1
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 15865
- Product name
- ARM1
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 15865
- Product name
- ARM1
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- 15865
- Product name
- ARM1
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $834
- Updated
- 2024/03/01
- Product number
- 135662
- Product name
- 4-(4-Benzylphenyl)-1,3-thiazol-2-amine
- Purity
- 95%+
- Packaging
- 2.500g
- Price
- $1266
- Updated
- 2021/12/16
ARM1 Chemical Properties,Usage,Production
Description
Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-
Uses
Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 μM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 μM). ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.[Cayman Chemical]
References
[1]. stsiapanava a, olsson u, wan m, et al. binding of pro-gly-pro at the active site of leukotriene a4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. proc natl acad sci u s a. 2014 mar 18;111(11):4227-32.
[2]. haeggstrm jz. leukotriene a4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene b4 biosynthesis. j biol chem. 2004 dec 3;279(49):50639-42.
[3]. snelgrove rj, jackson pl, hardison mt, et al. a critical role for lta4h in limiting chronic pulmonary neutrophilic inflammation. science. 2010 oct 1;330(6000):90-4.
ARM1 Preparation Products And Raw materials
Raw materials
Preparation Products
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