NI-57
- Product Name
- NI-57
- CAS No.
- 1883548-89-7
- Chemical Name
- NI-57
- Synonyms
- CS-2795;NI57;NI 57;BRPF inhibitor NI57;NI-57, 10 mM in DMSO;Inhibitor,inhibit,NI 57,NI-57,NI57,Epigenetic Reader Domain;4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-2-methoxy-benzenesulfonamide;Benzenesulfonamide, 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-2-methoxy-
- CBNumber
- CB03156586
- Molecular Formula
- C19H17N3O4S
- Formula Weight
- 383.42
- MOL File
- 1883548-89-7.mol
NI-57 Property
- Boiling point:
- 580.1±60.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤25mg/ml in DMSO;30mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 7.89±0.20(Predicted)
- color
- White to off-white
- InChI
- 1S/C19H17N3O4S/c1-12-8-14-10-15(5-6-16(14)22(2)19(12)23)21-27(24,25)18-7-4-13(11-20)9-17(18)26-3/h4-10,21H,1-3H3
- InChIKey
- UEMQPCYDWCSVCU-UHFFFAOYSA-N
- SMILES
- O=S(NC1=CC=C(N(C)C(C(C)=C2)=O)C2=C1)(C3=C(OC)C=C(C#N)C=C3)=O
Safety
- WGK Germany
- WGK 3
- Storage Class
- 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects - Hazard Classifications
- Acute Tox. 3 Oral
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1486
- Product name
- NI-57
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $111
- Updated
- 2025/07/31
- Product number
- 17662
- Product name
- NI-57
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 17662
- Product name
- NI-57
- Packaging
- 50mg
- Price
- $836
- Updated
- 2024/03/01
- Product number
- 17662
- Product name
- NI-57
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17662
- Product name
- NI-57
- Packaging
- 10mg
- Price
- $199
- Updated
- 2024/03/01
NI-57 Chemical Properties,Usage,Production
Description
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple tissues, axial skeleton, and the hematopoietic system. NI-57 is a potent inhibitor of the bromodomains of BRPF proteins that binds to BRPF1B, BRPF2, and BRPF3 with Kd values of 31, 108, and 408 nM, respectively, as determined by isothermal titration calorimetry. It is selective for BRPFs over other bromodomains. NI-57 shows accelerated FRAP recovery at 1 μM in the BRPF2 FRAP assay, preventing binding of full-length BRPF2 to chromatin. See the Structural Genomics Consortium (SGC) website for more information.
Uses
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple tissues, axial skeleton, and the hematopoietic system.
in vivo
NI-57 has favorable oral bioavailability in mice[1].
storage
Store at -20°C
References
[1]. http://www.thesgc.org/chemical-probes/ni-57
[2]. klein bj, lalonde me, cté j, et al. crosstalk between epigenetic readers regulates the moz/morf hat complexes. epigenetics. 2014 feb;9(2):186-93.
[3]. ullah m, pelletier n, xiao l, et al. molecular architecture of quartet moz/morf histone acetyltransferase complexes. mol cell biol. 2008 nov;28(22):6828-43.
NI-57 Preparation Products And Raw materials
Raw materials
Preparation Products
NI-57 Suppliers
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