MT-DADMe-ImmA
- Product Name
- MT-DADMe-ImmA
- CAS No.
- 653592-04-2
- Chemical Name
- MT-DADMe-ImmA
- Synonyms
- MTDIA;MT-DADMe-ImmA HCl;MT-DADMe-ImmA, 10 mM in DMSO;Methylthio-DADMe-Immucillin A;METHYLTHIO-DADME-IMMUCILLIN A; MTDIA;MTDADMeImmA,inhibit,MT DADMe ImmA,Inhibitor;MT-DADMe-ImmA (Methylthio-DADMe-Immucillin A;MTDIA; MTDIA HCL; METHYLTHIO-DADME-IMMUCILLIN A; MT-DADME-IMMA; MT-DADME-IMMA HCL;(3R,4S)-1-((4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((methylthio)methyl)pyrrolidin-3-ol;3-Pyrrolidinol, 1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylthio)methyl]-, (3R,4S)-
- CBNumber
- CB03164833
- Molecular Formula
- C13H19N5OS
- Formula Weight
- 293.39
- MOL File
- 653592-04-2.mol
MT-DADMe-ImmA Property
- Melting point:
- 108-110 °C
- Boiling point:
- 566.1±50.0 °C(Predicted)
- Density
- 1.412±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
- form
- A crystalline solid
- pka
- 14.13±0.40(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 29711
- Product name
- MT-DADMe-ImmA
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 29711
- Product name
- MT-DADMe-ImmA
- Packaging
- 25mg
- Price
- $704
- Updated
- 2024/03/01
- Product number
- 29711
- Product name
- MT-DADMe-ImmA
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 29711
- Product name
- MT-DADMe-ImmA
- Packaging
- 10mg
- Price
- $301
- Updated
- 2024/03/01
- Product number
- DC10332
- Product name
- MT-DADMe-ImmA
- Purity
- >98%
- Packaging
- 100mg
- Price
- $700
- Updated
- 2021/12/16
MT-DADMe-ImmA Chemical Properties,Usage,Production
Description
MT-DADMe-ImmA is an inhibitor of 5''-methylthioadenosine phosphorylase (MTAP; Ki = 1.7 nM). It increases levels of MTA , a product of polyamine metabolism, in FaDu human squamous cell carcinoma cells when used at a concentration of 1 μM. MT-DADMe-ImmA (5, 9, and 21 mg/kg per day for 28 days) reduces tumor growth in a FaDu mouse xenograft model.
Uses
MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM.
in vivo
The t1/2 for onset of inhibition is 50 min with complete inhibition by 250 min. MTAP activity slowly returns, giving a biological half-life for the action of oral MT-DADMe-ImmA of 6.3 days. The time-dependent growth of FaDu tumors in immunodeficient mice is suppressed by oral or intraperitoneal treatment with MT-DADMe-ImmA[2].
References
[1] Evans GB, et al. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem. 2005 Jul 14;48(14):4679-89. DOI:10.1021/jm050269z
[2] Basu I, et al. A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. J Biol Chem. 2007 Jul 20;282(29):21477-86. DOI:10.1074/jbc.M702287200
MT-DADMe-ImmA Preparation Products And Raw materials
Raw materials
Preparation Products
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