S1p receptor agonist 1
- Product Name
- S1p receptor agonist 1
- CAS No.
- 1514888-56-2
- Chemical Name
- S1p receptor agonist 1
- Synonyms
- CS-2465;YUN88562;icanbelimod;S1P-agonist-1;S1p receptor agonist 1;S1p receptor agonist 1, 10 mM in DMSO;1-(2-fluoro-4-(5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid;1-{2-fluoro-4-[5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl]-benzyl}-3-azetidine carboxylic acid;1-[[2-fluoro-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid;3-Azetidinecarboxylic acid, 1-[[2-fluoro-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-
- CBNumber
- CB03164873
- Molecular Formula
- C23H24FN3O3
- Formula Weight
- 409.45
- MOL File
- 1514888-56-2.mol
S1p receptor agonist 1 Property
- Boiling point:
- 566.3±60.0 °C(Predicted)
- Density
- 1.268±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 6.8 mg/mL (16.61 mM)
- form
- Solid
- pka
- 2?+-.0.20(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-6254
- Product name
- S1preceptoragonist1
- Purity
- 99.97%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-6254
- Product name
- S1preceptoragonist1
- Purity
- 99.97%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- CS-6254
- Product name
- S1preceptoragonist1
- Purity
- 99.97%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- CS-6254
- Product name
- S1preceptoragonist1
- Purity
- 99.97%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
- Product number
- CS-6254
- Product name
- S1preceptoragonist1
- Purity
- 99.97%
- Packaging
- 100mg
- Price
- $2520
- Updated
- 2021/12/16
S1p receptor agonist 1 Chemical Properties,Usage,Production
Uses
Icanbelimod (S1p receptor agonist 1) is a potent and orally active S1P receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). Icanbelimod has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). Icanbelimod is extracted from patent WO2015039587A1, Compound 2.
in vivo
Icanbelimod (oral administration; 0.01 mg/kg-1 mg/kg) at all dose is active, and only a dose of 0.01 mg/kg is required to observe a decrease in the number of peripheral blood lymphocytes by more than 50% and a decrease in the 1 mg/kg dose. Besides, this compound is lymphocyte-specific, which dose not significantly alter the number of peripheral monocytes and other white blood cells in SD rats[1].Icanbelimod (oral administration; 3 mg/kg; 12 days) is has been proved to block lymphocyte efflux. In the development of type II collagen-induced arthritis in rat model, compound 2 is effective in inhibiting the development of joint swelling in arthritis and joint structure destruction[1].Icanbelimod (oral administration; 0.3-1mg/kg; 30 days; once daily) inhibits the development of experimental autoimmune encephalitis (EAE) as a dose-dependent manner in mice model[1].
| Animal Model: | Lewis rats[1] |
| Dosage: | 3 mg/kg |
| Administration: | Oral administration |
| Result: | Decreased the severity score of arthritis in the four-legged rats. |
| Animal Model: | Female C57BL/6 mice[1] |
| Dosage: | 0.03, 0.1, and 1 mg/kg |
| Administration: | Oral administration |
| Result: | Decreased the severity score of EAE in MOG 35-55?induced mice. |
References
[1] Zhenwei, et al. Immune adjustment compound, use thereof and pharmaceutical composition comprising same. Patent WO2015039587A1
S1p receptor agonist 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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