6-HYDROXYDOPAMINE HYDROCHLORIDE
- Product Name
- 6-HYDROXYDOPAMINE HYDROCHLORIDE
- CAS No.
- 28094-15-7
- Chemical Name
- 6-HYDROXYDOPAMINE HYDROCHLORIDE
- Synonyms
- 6-OHDA;6-Hd HCl;Nsc233898;OxydopaMine HCL;TIMTEC-BB SBB003496;6-OHDA hydrochloride;6-Hydroxydopamine hy;TopaMine Hydrochloride;OxidopaMine Hydrochloride;6-hydroxydopaminechloride
- CBNumber
- CB0320270
- Molecular Formula
- C8H12ClNO3
- Formula Weight
- 205.64
- MOL File
- 28094-15-7.mol
6-HYDROXYDOPAMINE HYDROCHLORIDE Property
- Melting point:
- 232-233 °C (dec.)(lit.)
- storage temp.
- room temp
- solubility
- H2O: >50 mg/mL, clear, yellow to brown
- form
- powder
- color
- off-white to brown
- BRN
- 4274007
- InChI
- InChI=1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
- InChIKey
- QLMRJHFAGVFUAC-UHFFFAOYSA-N
- SMILES
- C1(CCN)=CC(=C(O)C=C1O)O.Cl
- EPA Substance Registry System
- 6-Hydroxydopamine hydrochloride (28094-15-7)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H4381
- Product name
- 6-Hydroxydopamine hydrochloride
- Purity
- ≥97% (titration), powder
- Packaging
- 100mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- H4381
- Product name
- 6-Hydroxydopamine hydrochloride
- Purity
- ≥97% (titration), powder
- Packaging
- 1g
- Price
- $850
- Updated
- 2024/03/01
- Product number
- H4381
- Product name
- 6-Hydroxydopamine hydrochloride
- Purity
- ≥97% (titration), powder
- Packaging
- 500mg
- Price
- $554
- Updated
- 2024/03/01
- Product number
- H941743
- Product name
- 6-Hydroxydopamine hydrochloride
- Packaging
- 10mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- H941743
- Product name
- 6-Hydroxydopamine hydrochloride
- Packaging
- 50mg
- Price
- $165
- Updated
- 2021/12/16
6-HYDROXYDOPAMINE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.
Uses
6-hydroxydopamine hydrochloride has been used:
- to induce Parkinson′s disease (PD) in rats
- to analyse cytotoxic effect of 6-OHDA on PC12 cell line
- to induce noradrenergic (NA) neuron deletion from the locus-coeruleus
General Description
Beige solid.
Air & Water Reactions
Hygroscopic. Water soluble.
Reactivity Profile
A weak acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 6-HYDROXYDOPAMINE HYDROCHLORIDE emits very toxic fumes.
Fire Hazard
Flash point data for 6-HYDROXYDOPAMINE HYDROCHLORIDE are not available. 6-HYDROXYDOPAMINE HYDROCHLORIDE is probably combustible.
Biological Activity
Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.
Biochem/physiol Actions
Neurotoxin that destroys catecholaminergic terminals.
6-HYDROXYDOPAMINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-HYDROXYDOPAMINE HYDROCHLORIDE manufacturers
- Product
- 6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-28
- Product
- 6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2023-07-13
- Product
- 6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08