6-HYDROXYDOPAMINE HYDROCHLORIDE

ChemicalBook > CAS DataBase List > 6-HYDROXYDOPAMINE HYDROCHLORIDE

6-HYDROXYDOPAMINE HYDROCHLORIDE

Product Name: 6-HYDROXYDOPAMINE HYDROCHLORIDE
CAS No.: 28094-15-7
Chemical Name: 6-HYDROXYDOPAMINE HYDROCHLORIDE
Synonyms: 6-OHDA;6-Hd HCl;Nsc233898;OxydopaMine HCL;TIMTEC-BB SBB003496;6-OHDA hydrochloride;6-Hydroxydopamine hy;TopaMine Hydrochloride;OxidopaMine Hydrochloride;6-hydroxydopaminechloride
CBNumber: CB0320270
Molecular Formula: C8H12ClNO3
Formula Weight: 205.64
MOL File: 28094-15-7.mol

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6-HYDROXYDOPAMINE HYDROCHLORIDE Property

Melting point:: 232-233 °C (dec.)(lit.)
storage temp.: room temp
solubility: H₂O: >50 mg/mL, clear, yellow to brown
form: powder
color: off-white to brown
BRN: 4274007
InChI: InChI=1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChIKey: QLMRJHFAGVFUAC-UHFFFAOYSA-N
SMILES: C1(CCN)=CC(=C(O)C=C1O)O.Cl
EPA Substance Registry System: 6-Hydroxydopamine hydrochloride (28094-15-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: DC4650000
F: 3-8-10-23

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H4381
Product name: 6-Hydroxydopamine hydrochloride
Purity: ≥97% (titration), powder
Packaging: 100mg
Price: $144
Updated: 2024/03/01

Sigma-Aldrich

Product number: H4381
Product name: 6-Hydroxydopamine hydrochloride
Purity: ≥97% (titration), powder
Packaging: 1g
Price: $850
Updated: 2024/03/01

Sigma-Aldrich

Product number: H4381
Product name: 6-Hydroxydopamine hydrochloride
Purity: ≥97% (titration), powder
Packaging: 500mg
Price: $554
Updated: 2024/03/01

TRC

Product number: H941743
Product name: 6-Hydroxydopamine hydrochloride
Packaging: 10mg
Price: $55
Updated: 2021/12/16

TRC

Product number: H941743
Product name: 6-Hydroxydopamine hydrochloride
Packaging: 50mg
Price: $165
Updated: 2021/12/16

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6-HYDROXYDOPAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.

Uses

6-hydroxydopamine hydrochloride has been used:

to induce Parkinson′s disease (PD) in rats
to analyse cytotoxic effect of 6-OHDA on PC12 cell line
to induce noradrenergic (NA) neuron deletion from the locus-coeruleus

General Description

Beige solid.

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

A weak acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 6-HYDROXYDOPAMINE HYDROCHLORIDE emits very toxic fumes.

Fire Hazard

Flash point data for 6-HYDROXYDOPAMINE HYDROCHLORIDE are not available. 6-HYDROXYDOPAMINE HYDROCHLORIDE is probably combustible.

Biological Activity

Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.

Biochem/physiol Actions

Neurotoxin that destroys catecholaminergic terminals.

6-HYDROXYDOPAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-HYDROXYDOPAMINE HYDROCHLORIDE Suppliers

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View Lastest Price from 6-HYDROXYDOPAMINE HYDROCHLORIDE manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: 6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-28

Hebei Guanlang Biotechnology Co,.LTD

Product: 6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2023-07-13

Career Henan Chemical Co

Product: 6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

28094-15-7, 6-HYDROXYDOPAMINE HYDROCHLORIDERelated Search:

Dopamine hydrochloride Acetylcholine Ethylamine hydrochloride Tyramine hydrochloride DOPAMINE HYDROCHLORIDE 5-HYDROXYDOPAMINE HYDROCHLORIDE,5-HYDROXYDOPAMINE HYDROCHLORIDE 99% RARECHEM AN KB 1616 RARECHEM AN KB 0077 RARECHEM AN KD 0076 RARECHEM AN KD 0298 RARECHEM AN KD 0559 RARECHEM AN KD 1619 6-HYDROXYDOPAMINE HYDROCHLORIDE

4-(2-Aminoethyl)-1,2,3-benzenetriol hydrochloride

6-Hd HCl

Nsc233898

OxidopaMine Hydrochloride

2,4,5-TrihydroxyphenethylamineHCl

2,4,5-Trihydroxyphenethylaminehydochloride

2,4,5-TRIHYDROXYPHENETHYLAMINEYDOCHLORIDE

2,4,5-Trihydroxyphenethylamine hydrochloride, 2,5-Dihydroxytyramine hydrochloride, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride, 6-OHDA

1,2,3-Benzenetriol, 4-(2-aminoethyl)-, hydrochloride

1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrochloride

2,4,5-TRIHYDROXYPHENETHYLAMINE HYDROCHLORIDE

2,5-DIHYDROXYTYRAMINE HYDROCHLORIDE

2-(2,4,5-TRIHYDROXYPHENYL)ETHYLAMINE HYDROCHLORIDE

TIMTEC-BB SBB003496

2,4-benzenetriol,5-(2-aminoethyl)-hydrochloride

5-(2-aminoethyl)-1,2,4-benzenetriolhydrochloride

6-hydroxydopaminechloride

5-(2-aminoethyl)-4-hydroxypyrocatechol hydrochloride

TopaMine Hydrochloride

5-(2-aMinoethyl)benzene-1,2,4-triol hydrochloride

OxydopaMine HCL

6-OHDA

6-HYDROXYDOPAMINE HYDROCHLORIDE

6-OHDA hydrochloride

6-Hydroxydopamine hy

Neuro-2a cells,p-p38,Interleukin Related,p38 MAPK,PC12 cells,Apoptosis,Dopamine Receptor,Mitophagy,neurotoxicity,Autophagy,Oxidopamine hydrochloride,6-OHDA,Prostaglandin E synthase,Cyclooxygenase,Lesch-Nyhan syndrome,inhibit,Mitochondrial Autophagy,PGE2,attention-deficit hyperactivity disorder,Parkinson’s disease,SH-SY5Y cells,Oxidopamine,Caspase,PGE synthase,Inhibitor,COX,6-Hydroxydopamine

28094-15-7

HO3C6H2CH2CH2NH2HCl

C8H11NO3ClH

Amino Alcohols

Building Blocks

Oxygen Compounds

Organic Building Blocks