6-HYDROXYDOPAMINE HYDROCHLORIDE

ChemicalBook > CAS DataBase List > 6-HYDROXYDOPAMINE HYDROCHLORIDE

6-HYDROXYDOPAMINE HYDROCHLORIDE

Product Name: 6-HYDROXYDOPAMINE HYDROCHLORIDE
CAS No.: 28094-15-7
Chemical Name: 6-HYDROXYDOPAMINE HYDROCHLORIDE
Synonyms: 6-OHDA;6-Hd HCl;Nsc233898;OxydopaMine HCL;TIMTEC-BB SBB003496;6-OHDA hydrochloride;6-Hydroxydopamine hy;TopaMine Hydrochloride;OxidopaMine Hydrochloride;6-hydroxydopaminechloride
CBNumber: CB0320270
Molecular Formula: C8H12ClNO3
Formula Weight: 205.64
MOL File: 28094-15-7.mol

Less

6-HYDROXYDOPAMINE HYDROCHLORIDE Property

Melting point:: 232-233 °C (dec.)(lit.)
storage temp.: room temp
solubility: H₂O: >50 mg/mL, clear, yellow to brown
form: powder
color: off-white to brown
BRN: 4274007
InChI: InChI=1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChIKey: QLMRJHFAGVFUAC-UHFFFAOYSA-N
SMILES: C1(CCN)=CC(=C(O)C=C1O)O.Cl
EPA Substance Registry System: 6-Hydroxydopamine hydrochloride (28094-15-7)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: DC4650000
F: 3-8-10-23

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H4381
Product name: 6-Hydroxydopamine hydrochloride
Purity: ≥97% (titration), powder
Packaging: 100mg
Price: $144
Updated: 2024/03/01

Sigma-Aldrich

Product number: H4381
Product name: 6-Hydroxydopamine hydrochloride
Purity: ≥97% (titration), powder
Packaging: 1g
Price: $850
Updated: 2024/03/01

Sigma-Aldrich

Product number: H4381
Product name: 6-Hydroxydopamine hydrochloride
Purity: ≥97% (titration), powder
Packaging: 500mg
Price: $554
Updated: 2024/03/01

TRC

Product number: H941743
Product name: 6-Hydroxydopamine hydrochloride
Packaging: 10mg
Price: $55
Updated: 2021/12/16

TRC

Product number: H941743
Product name: 6-Hydroxydopamine hydrochloride
Packaging: 50mg
Price: $165
Updated: 2021/12/16

Less

6-HYDROXYDOPAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.

Uses

6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.

Uses

6-hydroxydopamine hydrochloride has been used:

to induce Parkinson′s disease (PD) in rats
to analyse cytotoxic effect of 6-OHDA on PC12 cell line
to induce noradrenergic (NA) neuron deletion from the locus-coeruleus

General Description

Beige solid.

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

A weak acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 6-HYDROXYDOPAMINE HYDROCHLORIDE emits very toxic fumes.

Fire Hazard

Flash point data for 6-HYDROXYDOPAMINE HYDROCHLORIDE are not available. 6-HYDROXYDOPAMINE HYDROCHLORIDE is probably combustible.

Biological Activity

Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.

Biochem/physiol Actions

Neurotoxin that destroys catecholaminergic terminals.

Mechanism of action

The biochemical mechanism of toxicity of 6-Hydroxydopamine hydrochloride (6-OHDA) is as follows: 6-OHDA has two modes of action: it readily forms free radicals and it is a potent inhibitor of the mitochondrial respiratory chain complexes I and IV. The inhibition of respiratory enzymes by 6-OHDA is reversible and insensitive to free radical scavengers and iron chelators, except for desferrioxamine. Moreover, free radicals are not involved in the interaction between 6-OHDA and the respiratory chain, and the two mechanisms are biochemically independent, although they may act synergistically in vivo.

6-HYDROXYDOPAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

6-HYDROXYDOPAMINE HYDROCHLORIDE Suppliers

Canada 1 China 81 Germany 1 India 2 Japan 1 South Korea 1 Sweden 1 Switzerland 1 United Kingdom 3 United States 12 Global 104

Huayin Sample Biological Technology Co. LTD

Tel: 13892502238
Email: 1453186328@qq.com
Country: China
ProdList: 493
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 17501653715
Email: xingui2022@126.com
Country: China
ProdList: 10015
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.

Tel: 027-65388397 18164111589
Fax: 027-65388397
Email: 3321478047@qq.com
Country: China
ProdList: 1996
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
ProdList: 1931
Advantage: 55

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8012
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Wellman Pharmaceutical Group Limited

Tel: 027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 4027
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15084
Advantage: 58

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: 021-58958618
Email: sales@uhnshanghai.com
Country: China
ProdList: 2128
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-010-010-62971590 18548936886
Fax: 010-62340519
Email: jack@oka-vip.com
Country: China
ProdList: 6897
Advantage: 58

Hefei Bomei Biotechnology Co., Ltd.

Tel: 13856598764
Email: 531626407@qq.com
Country: China
ProdList: 3007
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Zhengzhou Alfa Chemical Co.,Ltd

Tel: +8618530059196
Email: sale04@alfachem.cn
Country: China
ProdList: 11817
Advantage: 58

Finetech Industry Limited

Tel: +86-27-87465837 +8618971612321
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9639
Advantage: 58

Hebei Mojin Biotechnology Co., Ltd

Tel: +86 13288715578 +8613288715578
Email: sales@hbmojin.com
Country: China
ProdList: 12834
Advantage: 58

Hebei Chuanghai Biotechnology Co,.LTD

Tel: +86-13131129325
Fax: 86-0311-66562153
Email: sales1@chuanghaibio.com
Country: China
ProdList: 5889
Advantage: 58

Shanghai Jiegu Biotechnology Co., Ltd.

Tel: 021-51698675
Email: jiejiegroup@126.com
Country: China
ProdList: 4290
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29811
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Cangzhou Pintuo Biotechnology Co., Ltd.

Tel: 15231732623
Email: 1979763395@qq.com
Country: China
ProdList: 187
Advantage: 58

Beijing Aomi Jiade Pharmaceutical Technology Co., Ltd

Tel: +86-13522808617 +86-13522808617
Email: omichem@126.com
Country: China
ProdList: 9211
Advantage: 58

Zhengzhou Convergence Chemical Co. LTD

Tel: 0371-53736046 13393710386
Fax: QQ:2853979814
Email: 2853979814@qq.com
Country: China
ProdList: 9990
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44806
Advantage: 58

DONBOO AMINO ACID COMPANY

Tel: +8613063595538
Email: donboo@donboo.com
Country: China
ProdList: 9363
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7977
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10011
Advantage: 58

Hebei mo Jin biotechnology co., ltd

Tel: 15097329902
Fax: 18503279000
Email: sales@hebeimojin.com
Country: China
ProdList: 1953
Advantage: 58

Guangzhou Yunmen Biotechnology Co., Ltd

Tel: 18902340307 18902340307
Fax: 0751-2819901
Email: 3356812514@qq.com
Country: China
ProdList: 9244
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 13774214275
Email: zhouzz@univ-bio.com
Country: China
ProdList: 24994
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7890
Advantage: 58

ChemeGen 中国

Tel: 18818260767
Fax: QQ 3610331285
Email: 2625930290@qq.com
Country: China
ProdList: 6973
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 6887
Advantage: 58

Shanghai Yaji Biological Technology Co., Ltd.

Tel: 021-34661275 15301693058
Email: yajikit@163.com
Country: China
ProdList: 9670
Advantage: 58

JiangSu Star Science Co.,Ltd

Tel: 400-400-605-7200-7200 17312445705
Email: sales022@b2star.com
Country: China
ProdList: 3761
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9956
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Shaanxi Dideu Newmaterial Co., Ltd.

Tel: 029-87576359 15353716720
Email: 1039@dideu.com
Country: China
ProdList: 10009
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 3401
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Qiyuan (Guangdong) Pharmaceutical Chemical Co., Ltd.

Tel: 400-666-9280 18026564465
Email: 304903156@qq.com
Country: China
ProdList: 8001
Advantage: 58

Less

View Lastest Price from 6-HYDROXYDOPAMINE HYDROCHLORIDE manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2024-08-20

Hebei Mojin Biotechnology Co., Ltd

Product: 6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-28

Career Henan Chemical Co

Product: 6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

28094-15-7, 6-HYDROXYDOPAMINE HYDROCHLORIDERelated Search:

Dopamine hydrochloride Acetylcholine Ethylamine hydrochloride Tyramine hydrochloride DOPAMINE HYDROCHLORIDE 5-HYDROXYDOPAMINE HYDROCHLORIDE,5-HYDROXYDOPAMINE HYDROCHLORIDE 99% RARECHEM AN KB 1616 RARECHEM AN KB 0077 RARECHEM AN KD 0076 RARECHEM AN KD 0298 RARECHEM AN KD 0559 RARECHEM AN KD 1619 6-HYDROXYDOPAMINE HYDROCHLORIDE

4-(2-Aminoethyl)-1,2,3-benzenetriol hydrochloride

6-Hd HCl

Nsc233898

OxidopaMine Hydrochloride

2,4,5-TrihydroxyphenethylamineHCl

2,4,5-Trihydroxyphenethylaminehydochloride

2,4,5-TRIHYDROXYPHENETHYLAMINEYDOCHLORIDE

2,4,5-Trihydroxyphenethylamine hydrochloride, 2,5-Dihydroxytyramine hydrochloride, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride, 6-OHDA

1,2,3-Benzenetriol, 4-(2-aminoethyl)-, hydrochloride

1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrochloride

2,4,5-TRIHYDROXYPHENETHYLAMINE HYDROCHLORIDE

2,5-DIHYDROXYTYRAMINE HYDROCHLORIDE

2-(2,4,5-TRIHYDROXYPHENYL)ETHYLAMINE HYDROCHLORIDE

TIMTEC-BB SBB003496

2,4-benzenetriol,5-(2-aminoethyl)-hydrochloride

5-(2-aminoethyl)-1,2,4-benzenetriolhydrochloride

6-hydroxydopaminechloride

5-(2-aminoethyl)-4-hydroxypyrocatechol hydrochloride

TopaMine Hydrochloride

5-(2-aMinoethyl)benzene-1,2,4-triol hydrochloride

OxydopaMine HCL

6-OHDA

6-HYDROXYDOPAMINE HYDROCHLORIDE

6-OHDA hydrochloride

6-Hydroxydopamine hy

Neuro-2a cells,p-p38,Interleukin Related,p38 MAPK,PC12 cells,Apoptosis,Dopamine Receptor,Mitophagy,neurotoxicity,Autophagy,Oxidopamine hydrochloride,6-OHDA,Prostaglandin E synthase,Cyclooxygenase,Lesch-Nyhan syndrome,inhibit,Mitochondrial Autophagy,PGE2,attention-deficit hyperactivity disorder,Parkinson’s disease,SH-SY5Y cells,Oxidopamine,Caspase,PGE synthase,Inhibitor,COX,6-Hydroxydopamine

28094-15-7

HO3C6H2CH2CH2NH2HCl

C8H11NO3ClH

Amino Alcohols

Building Blocks

Oxygen Compounds

Organic Building Blocks