ChemicalBook > CAS DataBase List > 7-Keto-dehydroepiandrosterone
7-Keto-dehydroepiandrosterone
Regulation- Product Name
- 7-Keto-dehydroepiandrosterone
- CAS No.
- 566-19-8
- Chemical Name
- 7-Keto-dehydroepiandrosterone
- Synonyms
- 7-Oxo-DHEA;7-KETO DHEA;7-KETO DHEA, HPLC 98%;ABiraterone Impurity I;7-keto DHEA(7-Oxo DHEA);Ketodehydroepiandrosterone;7-keto DHEA Acetate Powder;7-Oxo-dehydroepiandrosterone;5-Androsten-3β-ol-7,17-dione;Androst-5-en-3-ol-7,17-dione
- CBNumber
- CB0329495
- Molecular Formula
- C19H26O3
- Formula Weight
- 302.41
- MOL File
- 566-19-8.mol
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7-Keto-dehydroepiandrosterone Property
- Melting point:
- 245-248 °C
- Boiling point:
- 477.1±45.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- solubility
- DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml
- form
- A crystalline solid
- pka
- 14.67±0.60(Predicted)
- InChI
- InChI=1/C19H26O3/c1-18-7-5-12(20)9-11(18)10-15(21)17-13-3-4-16(22)19(13,2)8-6-14(17)18/h10,12-14,17,20H,3-9H2,1-2H3/t12-,13-,14-,17-,18-,19-/s3
- InChIKey
- KPRGOTLNGIBVFL-YQJRJXGQNA-N
- SMILES
- C[C@]12CC[C@H](O)CC1=CC(=O)[C@@]1([H])[C@]3([H])CCC(=O)[C@@]3(C)CC[C@]21[H] |&1:1,4,11,13,19,23,r|
- CAS DataBase Reference
- 566-19-8(CAS DataBase Reference)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 22497
- Product name
- 7-keto Dehydroepiandrosterone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22497
- Product name
- 7-keto Dehydroepiandrosterone
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $78
- Updated
- 2024/03/01
IsoSciences
- Product number
- 13390
- Product name
- Ketodehydroepiandrosterone
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 147683
- Product name
- (3S,8R,9S,10R,13S,14S)-3-Hydroxy-10,13-dimethyl-3,4,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-7,17(2H,8H)-dione
- Purity
- 95%
- Packaging
- 25g
- Price
- $78
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 147683
- Product name
- (3S,8R,9S,10R,13S,14S)-3-Hydroxy-10,13-dimethyl-3,4,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-7,17(2H,8H)-dione
- Purity
- 95%
- Packaging
- 100g
- Price
- $260
- Updated
- 2021/12/16
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7-Keto-dehydroepiandrosterone Chemical Properties,Usage,Production
Regulation
The FDA has proposed that 7-Keto-DHEA be included among substances banned from use in compounded drugs.
Description
7-Ketodehydroepiandrosterone (7-Keto-dehydroepiandrosterone; 7-keto-DHEA), chemically known under 3-acetyl-7-oxo-dehydroepiandrosterone, is a naturally occurring metabolite of the steroid hormone dehydroepiandrosterone (DHEA) and is marketed as such an anti-obesity dietary supplement. The synthesis of 7-keto-DHEA begins with an irreversible hydroxylation of DHEA in the position C7 by cytochrome P450 7B1 (CYP7B1) under the formation of 7 α-hydroxy-dehydroepiandrosterone (7 α-OH-DHEA). β-hydroxysteroid dehydrogenase type 1 (11 β-HSD 1) then catalyzes the interconversion of 7 α-OH-DHEA and 7 β-hydroxy-dehydroepiandrosterone (7 β-OH-DHEA) through a 7-keto-DHEA intermediary. DHEA is a "parent hormone" produced by glands near the kidneys. However, unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. Taking 7-keto-DHEA by mouth or applying it to the skin does not increase the level of steroid hormones in the blood. People take 7-keto-DHEA for obesity, muscle strength, anxiety, depression, and other conditions. However, there is no good scientific evidence to support these uses[1].
Uses
7-Keto Dehydro Epiandrosterone-d6 is the isotope labelled analog of 7-Keto Dehydro Epiandrosterone (K187700); a metabolite of Dehydroepiandrosterone (DHEA) (D229585) which is the major secretory steroidal product of the adrenal gland.
Definition
ChEBI: 7-ketodehydroepiandrosterone is a 3beta-hydroxy-Delta(5)-steroid that is dehydroepiandrosterone carrying an additional oxo group at position 7. It has a role as a human blood serum metabolite, a nutraceutical and a prohormone. It is a 17-oxo steroid, a 3beta-hydroxy-Delta(5)-steroid, an androstanoid and a 7-oxo steroid. It is functionally related to a dehydroepiandrosterone.
Side effects
7-Keto-dehydroepiandrosterone might cause mild side effects such as nausea, dizziness, or low blood pressure in some people.
Physiological effects
In the past ten years, a large number of studies have shown that 7-keto dehydroepiandrosterone has stronger physiological activity than DHEA, especially in anti-aging, enhancing immunity, improving memory, enhancing brain function, preventing Alzheimer’s and diabetes , It has a strong effect on reducing the risk of heart disease, losing weight, increasing bone density and muscle vitality.
References
[1] Nishanthini Jeyaprakash. “A systematic review of the impact of 7-keto-DHEA on body weight.” Archives of Gynecology and Obstetrics 308 3 (2022): 777–785.
7-Keto-dehydroepiandrosterone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Keto-dehydroepiandrosterone manufacturers
Shaanxi Franta Biotechnology Co., Ltd
- Product
- 7-Keto-dehydroepiandrosterone 566-19-8
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2024-09-23
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
- Product
- 7-Keto-dehydroepiandrosterone 566-19-8
- Price
- US $1000.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 1000kg/month
- Release date
- 2021-08-05
Shandong Hanjiang Chemical Co., Ltd
- Product
- 7-Keto-Dehydroepiandrosterone 566-19-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10T
- Release date
- 2024-01-10
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