Acid-PEG2-t-butyl ester
- Product Name
- Acid-PEG2-t-butyl ester
- CAS No.
- 2086688-99-3
- Chemical Name
- Acid-PEG2-t-butyl ester
- Synonyms
- 3-(2-(3-(tert-Butoxy)-3-oxopropoxy)ethoxy)propanoic acid;COOH-PEG2-OtBu;Acid-PEG2-C2-Boc;Acid-PEG2-t-Bu Ester;Acid-PEG2-t-butyl ester;t-butyl ester-PEG1-acid;3-[2-(2-Boc-ethoxy)ethoxy]propanoic Acid;3-[2-(2-Carboxyethoxy)ethoxy]propanoic acid tert-butyl ester;Propanoic acid, 3-[2-(2-carboxyethoxy)ethoxy]-, 1-(1,1-dimethylethyl) ester
- CBNumber
- CB03303326
- Molecular Formula
- C12H22O6
- Formula Weight
- 262.3
- MOL File
- 2086688-99-3.mol
Acid-PEG2-t-butyl ester Property
- Boiling point:
- 384.3±27.0 °C(Predicted)
- Density
- 1.104±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, sealed storage, away from moisture
- solubility
- Soluble in Water, DMSO, DMF
- pka
- 4.27±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C12H22O6/c1-12(2,3)18-11(15)5-7-17-9-8-16-6-4-10(13)14/h4-9H2,1-3H3,(H,13,14)
- InChIKey
- FVMOAKLTZMCDOV-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)CCOCCOCCC(O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-23510
- Product name
- Acid-PEG2-t-butylester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- BP-23510
- Product name
- Acid-PEG2-t-butylester
- Purity
- 98%
- Packaging
- 250mg
- Price
- $680
- Updated
- 2021/12/16
- Product number
- BP-23510
- Product name
- Acid-PEG2-t-butylester
- Purity
- 98%
- Packaging
- 500mg
- Price
- $980
- Updated
- 2021/12/16
- Product number
- BP-23510
- Product name
- Acid-PEG2-t-butylester
- Purity
- 98%
- Packaging
- 1g
- Price
- $1650
- Updated
- 2021/12/16
Acid-PEG2-t-butyl ester Chemical Properties,Usage,Production
Description
Acid-PEG2-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Acid-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Acid-PEG2-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Acid-PEG2-t-butyl ester Suppliers
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- +1-781-999-5354; +17819995354
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- United States
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View Lastest Price from Acid-PEG2-t-butyl ester manufacturers
- Product
- COOH-PEG2-COOtBu 2086688-99-3
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23