BENZIODARONE
- Product Name
- BENZIODARONE
- CAS No.
- 68-90-6
- Chemical Name
- BENZIODARONE
- Synonyms
- l2329;Dilaf;algocor;Vasilar;carofam;Corofam;amplivix;cardivix;2329labaz;Retrangor
- CBNumber
- CB0330990
- Molecular Formula
- C17H12I2O3
- Formula Weight
- 518.08
- MOL File
- 68-90-6.mol
BENZIODARONE Property
- Melting point:
- 167°
- Density
- 1.9173 (estimate)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- color
- Beige
- Water Solubility
- 5.881mg/L(20 ºC)
- CAS DataBase Reference
- 68-90-6
Safety
- HS Code
- 2906.19.5000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E1290
- Product name
- Benziodarone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $121
- Updated
- 2024/03/01
- Product number
- E1290
- Product name
- Benziodarone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $425
- Updated
- 2024/03/01
- Product number
- B197860
- Product name
- Benziodarone
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- API0010003
- Product name
- BENZIODARONE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $157.5
- Updated
- 2021/12/16
- Product number
- 0208BA
- Product name
- Benziodarone
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
BENZIODARONE Chemical Properties,Usage,Production
Originator
Amplivix,Sigma-Tau
Uses
Benziodarone is a uricosuric drug,it is used to effectively to control hyperuricemia in renal transplantation.
Definition
ChEBI: Benziodarone is an aromatic ketone.
Manufacturing Process
The starting product 2-ethyl-3-benzofuranyl p-hydroxyphenyl ketone
(benzaron) was prepared in 4 steps:
1. First step was a reaction of salicylic aldehyde with chloroacetone to produce
2-acetyl-1-benzofuran.
2. It was reduced by hydrazine hydrate in an alkaline medium by process of
Hyuang-Minlon, J.A.C.S., 1946, 68, 2487 to give 2-ethyl-1-benzofurane.
3. 2-Ethyl-3-(4-methoxybenzoyl)-1-benzofuran was obtained from 2-ethyl-1-
benzofuran and 4-methoxy-benzoylchloride in a presence of tin tetrachloride.
4. It was heated with pyridine hydrochloride at 200°-220°C to give 2-ethyl-3-
benzofuranyl p-hydroxyphenyl ketone (benzaron) as described in N.P.B.Hoi,
C.Beaudet; US Patent No. 3,012,042; Dec. 5, 1961.
Benzaron (1 part) was dissolved in a very slight excess of 3% caustic soda. To
this solution is gradually added a slight excess of iodine dissolved in a 25%
aqueous solution of potassium iodide. The resultant solution is acidified with a
20% solution of sodium bisulphite, centrifuged, washed with water and then
recrystallized in acetic acid to give of 2-ethyl-3-benzofuranyl 4-hydroxy-3,5-
diiodophenyl ketone. MP: 167°C.
Therapeutic Function
Coronary vasodilator, Uricosuric
Safety Profile
A poison bj7 intraperitoneal and intravenous routes. Moderately toxic by ingestion. A flammable liquid. When heated to decomposition it emits toxic vapors of I-.
BENZIODARONE Preparation Products And Raw materials
Raw materials
Preparation Products
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