BENZIODARONE

Product Name: BENZIODARONE
CAS No.: 68-90-6
Chemical Name: BENZIODARONE
Synonyms: l2329;Dilaf;algocor;Vasilar;carofam;Corofam;amplivix;cardivix;2329labaz;Retrangor
CBNumber: CB0330990
Molecular Formula: C17H12I2O3
Formula Weight: 518.08
MOL File: 68-90-6.mol

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BENZIODARONE Property

Melting point:: 167°
Density: 1.9173 (estimate)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: Beige
Water Solubility: 5.881mg/L(20 ºC)
CAS DataBase Reference: 68-90-6

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Safety

HS Code: 2906.19.5000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1290
Product name: Benziodarone
Purity: >98.0%(GC)
Packaging: 1g
Price: $121
Updated: 2024/03/01

TCI Chemical

Product number: E1290
Product name: Benziodarone
Purity: >98.0%(GC)
Packaging: 5g
Price: $425
Updated: 2024/03/01

TRC

Product number: B197860
Product name: Benziodarone
Packaging: 10mg
Price: $150
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010003
Product name: BENZIODARONE
Purity: 95.00%
Packaging: 1MG
Price: $157.5
Updated: 2021/12/16

AK Scientific

Product number: 0208BA
Product name: Benziodarone
Packaging: 1g
Price: $225
Updated: 2021/12/16

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BENZIODARONE Chemical Properties,Usage,Production

Originator

Amplivix,Sigma-Tau

Uses

Benziodarone is a uricosuric drug,it is used to effectively to control hyperuricemia in renal transplantation.

Definition

ChEBI: Benziodarone is an aromatic ketone.

Manufacturing Process

The starting product 2-ethyl-3-benzofuranyl p-hydroxyphenyl ketone (benzaron) was prepared in 4 steps:
1. First step was a reaction of salicylic aldehyde with chloroacetone to produce 2-acetyl-1-benzofuran.
2. It was reduced by hydrazine hydrate in an alkaline medium by process of Hyuang-Minlon, J.A.C.S., 1946, 68, 2487 to give 2-ethyl-1-benzofurane.
3. 2-Ethyl-3-(4-methoxybenzoyl)-1-benzofuran was obtained from 2-ethyl-1- benzofuran and 4-methoxy-benzoylchloride in a presence of tin tetrachloride. 4. It was heated with pyridine hydrochloride at 200°-220°C to give 2-ethyl-3- benzofuranyl p-hydroxyphenyl ketone (benzaron) as described in N.P.B.Hoi, C.Beaudet; US Patent No. 3,012,042; Dec. 5, 1961.
Benzaron (1 part) was dissolved in a very slight excess of 3% caustic soda. To this solution is gradually added a slight excess of iodine dissolved in a 25% aqueous solution of potassium iodide. The resultant solution is acidified with a 20% solution of sodium bisulphite, centrifuged, washed with water and then recrystallized in acetic acid to give of 2-ethyl-3-benzofuranyl 4-hydroxy-3,5- diiodophenyl ketone. MP: 167°C.

Therapeutic Function

Coronary vasodilator, Uricosuric

Safety Profile

A poison bj7 intraperitoneal and intravenous routes. Moderately toxic by ingestion. A flammable liquid. When heated to decomposition it emits toxic vapors of I-.

BENZIODARONE Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZIODARONE Suppliers

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68-90-6, BENZIODARONERelated Search:

Bisoprolol Amiodarone hydrochloride 2-BUTYL-3-(3,5-DIIODO-4-(OXYACETIC ACID ETHYL ESTER)-BENZOYL)-BENZOFURAN 2-Butyl-3-(3,5-Diiodo-4-hydroxy benzoyl) benzofuran Desethylamiodarone Amiodarone BENZIODARONE

BENZIODARONE

2-Ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl ketone

Vasilar

2329labaz

2-ethyl-3-(3’,5’-diiodo-4’-hydroxybenzoyl)-cumarone

3-(3,5-diiodo-4-hydroxybenzoyl)-2-ethyl-benzofura

3,5-diiodo-4-hydroxyphenyl2-ethyl-3-benzofuranylketone

aethyl-2-(3’,5’-dijod-4’-oxybenzoyl)-3cumaron

algocor

amplivix

benziodaron

cardivix

carofam

coronal-crinos

dilafurane

dila-vasal

ketone,3,5-diiodo-4-hydroxyphenyl2-ethyl-3-benzofuranyl

l2329

Benzoiodarone

Corofam

Retrangor

(2-ethyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-diiodophenyl)methanone

(2-ethyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-diiodo-phenyl)methanone

(2-ethylbenzofuran-3-yl)-(4-hydroxy-3,5-diiodo-phenyl)methanone

(2-Ethyl-3-benzofuranyl)(4-hydroxy-3,5-diiodophenyl)Methanone

2-Ethyl-3-(3,5-diiodo-4-hydroxybenzoyl)-3-couMarone

2-Ethyl-3-(3,5-diiodo-4-hydroxybenzoyl)benzofuran

Dilaf

NSC 82133

Methanone, (2-ethyl-3-benzofuranyl)(4-hydroxy-3,5-diiodophenyl)-

2-Ethyl-3-(4-hydroxy-3,5-diiodobenzoyl)benzofuran

Dilacoron

68-90-6

C17H12I2O3

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals