AD80

ChemicalBook > CAS DataBase List > AD80

Product Name: AD80
CAS No.: 1384071-99-1
Chemical Name: AD80
Synonyms: AD80;Reaxys ID: 27131146;Inhibitor,Raf,AD 80,inhibit,Raf kinases,AD-80,Ribosomal S6 Kinase (RSK),S6K,RET,AD80,Src;1-(4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-methyl-5-(trifluoromethyl)phenyl)urea;1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea;Urea, N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-
CBNumber: CB03310308
Molecular Formula: C22H19F4N7O
Formula Weight: 473.43
MOL File: 1384071-99-1.mol

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AD80 Property

Boiling point:: 530.9±50.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO:122.0(Max Conc. mg/mL);257.69(Max Conc. mM)
Ethanol:94.0(Max Conc. mg/mL);198.55(Max Conc. mM)
pka: 12.47±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6926
Product name: AD80
Purity: 99.85%
Packaging: 1mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-6926
Product name: AD80
Purity: 99.85%
Packaging: 5mg
Price: $210
Updated: 2021/12/16

ChemScene

Product number: CS-6926
Product name: AD80
Purity: 99.85%
Packaging: 10mg
Price: $360
Updated: 2021/12/16

ChemScene

Product number: CS-6926
Product name: AD80
Purity: 99.85%
Packaging: 25mg
Price: $720
Updated: 2021/12/16

ChemScene

Product number: CS-6926
Product name: AD80
Purity: 99.85%
Packaging: 50mg
Price: $1200
Updated: 2021/12/16

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AD80 Chemical Properties,Usage,Production

Biological Activity

AD80, a multi-kinase inhibitor, is more active against human RET (c-RET), BRAF, S6K, and SRC, but less active against mTOR than AD57 or AD58. Its IC50 value for RET (c-RET) is 4 nM.

in vivo

AD80 is a potent RET inhibitor with favorable pharmacokinetic profile in clinically relevant RET fusion-driven tumor models. In patient-derived xenograft species, AD80 effectively reduced RET-rearranged tumor size.

target

Target	Value
Raf (Cell-free)
Src < br/> (Cell-free)
S6 Kinase (Cell-free)
RET V804M (Cell-free assay)	0.4 nM
RET V804L (Cell-free assay)	0.6 nM

AD80 Preparation Products And Raw materials

Raw materials

Preparation Products

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1384071-99-1, AD80Related Search:

AD80

1-(4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-methyl-5-(trifluoromethyl)phenyl)urea

Reaxys ID: 27131146

Urea, N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-

1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

Inhibitor,Raf,AD 80,inhibit,Raf kinases,AD-80,Ribosomal S6 Kinase (RSK),S6K,RET,AD80,Src

1384071-99-1

C22H19F4N7O