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AD80

Product Name
AD80
CAS No.
1384071-99-1
Chemical Name
AD80
Synonyms
AD80;Reaxys ID: 27131146;Inhibitor,Raf,AD 80,inhibit,Raf kinases,AD-80,Ribosomal S6 Kinase (RSK),S6K,RET,AD80,Src;1-(4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-methyl-5-(trifluoromethyl)phenyl)urea;1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea;Urea, N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-
CBNumber
CB03310308
Molecular Formula
C22H19F4N7O
Formula Weight
473.43
MOL File
1384071-99-1.mol
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AD80 Property

Boiling point:
530.9±50.0 °C(Predicted)
Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO:122.0(Max Conc. mg/mL);257.69(Max Conc. mM)
Ethanol:94.0(Max Conc. mg/mL);198.55(Max Conc. mM)
pka
12.47±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6926
Product name
AD80
Purity
99.85%
Packaging
1mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-6926
Product name
AD80
Purity
99.85%
Packaging
5mg
Price
$210
Updated
2021/12/16
ChemScene
Product number
CS-6926
Product name
AD80
Purity
99.85%
Packaging
10mg
Price
$360
Updated
2021/12/16
ChemScene
Product number
CS-6926
Product name
AD80
Purity
99.85%
Packaging
25mg
Price
$720
Updated
2021/12/16
ChemScene
Product number
CS-6926
Product name
AD80
Purity
99.85%
Packaging
50mg
Price
$1200
Updated
2021/12/16
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AD80 Chemical Properties,Usage,Production

Biological Activity

AD80, a multi-kinase inhibitor, is more active against human RET (c-RET), BRAF, S6K, and SRC, but less active against mTOR than AD57 or AD58. Its IC50 value for RET (c-RET) is 4 nM.

in vivo

AD80 is a potent RET inhibitor with favorable pharmacokinetic profile in clinically relevant RET fusion-driven tumor models. In patient-derived xenograft species, AD80 effectively reduced RET-rearranged tumor size.

target

TargetValue
Raf
(Cell-free)
Src < br/> (Cell-free)
S6 Kinase
(Cell-free)
RET V804M
(Cell-free assay)		 0.4 nM
RET V804L
(Cell-free assay)		 0.6 nM

AD80 Preparation Products And Raw materials

Raw materials

Preparation Products

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AD80 Suppliers

China 60 India 1 United States 3 USA 1 Global 65

1384071-99-1, AD80Related Search:


  • AD80
  • 1-(4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-methyl-5-(trifluoromethyl)phenyl)urea
  • Reaxys ID: 27131146
  • Urea, N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-
  • 1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
  • Inhibitor,Raf,AD 80,inhibit,Raf kinases,AD-80,Ribosomal S6 Kinase (RSK),S6K,RET,AD80,Src
  • 1384071-99-1
  • C22H19F4N7O