DSR 6434
- Product Name
- DSR 6434
- CAS No.
- 1059070-10-8
- Chemical Name
- DSR 6434
- Synonyms
- DSR 6434;DSR6434,DSR 6434;6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one;6-Amino-2-(butylamino)-9-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one;8H-Purin-8-one, 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-
- CBNumber
- CB03310328
- Molecular Formula
- C19H28N8O2
- Formula Weight
- 400.48
- MOL File
- 1059070-10-8.mol
DSR 6434 Property
- Density
- 1.283±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:145.03(Max Conc. mg/mL);362.12(Max Conc. mM)
- form
- A solid
- pka
- 10.22±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4809
- Product name
- DSR6434
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $219
- Updated
- 2021/12/16
- Product number
- 4809
- Product name
- DSR6434
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $918
- Updated
- 2021/12/16
- Product number
- 255202
- Product name
- DSR 6434
- Packaging
- 10mg
- Price
- $475
- Updated
- 2021/12/16
- Product number
- C982610
- Product name
- DSR6434
- Packaging
- 10mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CS-0032972
- Product name
- DSR-6434
- Purity
- 99.49%
- Packaging
- 50mg
- Price
- $900
- Updated
- 2021/12/16
DSR 6434 Chemical Properties,Usage,Production
Uses
DSR 6434 (cas# 1059070-10-8) is a useful research chemical.DSR is a TLR7 agonist. DSR 6434 indicated an optimal balance between the agonistic potency and high water solubility.
Biological Activity
DSR 6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist with EC50 of 7.2 nM and 4.6 nM for human and mouse TLR7, respectively. It has strong antitumor effect.
in vitro
To assess the specificity of DSR-6434 toward TLR7, an NF-κB-driven reporter assay is performed in HEK293 cells engineered to express either hTLR7, TLR8 or TLR9. In this assay, successful binding of DSR-6434 to the specific receptor leads to NF-κB activation.
target
| TLR7 7.2 nM (EC 50 , Human) | TLR7 4.6 nM (EC 50 , Mice) |
storage
Store at -20°C
DSR 6434 Preparation Products And Raw materials
Raw materials
Preparation Products
DSR 6434 Suppliers
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4153
- Advantage
- 55
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29797
- Advantage
- 68
- Tel
- 021-34625901
- 420970979@qq.com
- Country
- China
- ProdList
- 5751
- Advantage
- 58
- Tel
- 15971444841
- Fax
- 18327183813
- amber@biochempartner.com
- Country
- China
- ProdList
- 3063
- Advantage
- 58
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19892
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- +86-02787215551 +86-19945035818
- Fax
- 027-87215551
- 2936752263@qq.com
- Country
- China
- ProdList
- 7955
- Advantage
- 58
- Tel
- 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 3063
- Advantage
- 58
- Tel
- 15071299552
- Fax
- QQ:262933239
- 262933239@qq.com
- Country
- China
- ProdList
- 6637
- Advantage
- 58