CU CPT 4a

Product Name: CU CPT 4a
CAS No.: 1279713-77-7
Chemical Name: CU CPT 4a
Synonyms: TLR3-IN-1;CU CPT 4a;TLR3-IN-1, 10 mM in DMSO;(3-Chloro-6-fluorobenzo[b]thiophene-2-carbonyl)-D-phenylalanine;N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine;D-Phenylalanine, N-[(3-chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-;TLR3/dsRNA complex,inhibit,CU-CPT 4a,TNF-α,protein-RNA interaction,IL-1β,TLR-3-IN-1,Inhibitor,TLR3 IN 1,TLR3IN1,Toll-like Receptor (TLR)
CBNumber: CB03310333
Molecular Formula: C18H13ClFNO3S
Formula Weight: 377.82
MOL File: 1279713-77-7.mol

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CU CPT 4a Property

storage temp.: Store at 4°C
solubility: <37.78mg/ml in DMSO
form: solid
color: White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 4883
Product name: CUCPT4a
Purity: ≥98%(HPLC)
Packaging: 10
Price: $233
Updated: 2021/12/16

Tocris

Product number: 4883
Product name: CUCPT4a
Purity: ≥98%(HPLC)
Packaging: 50
Price: $969
Updated: 2021/12/16

TRC

Product number: C852005
Product name: CUCPT4a
Packaging: 1mg
Price: $115
Updated: 2021/12/16

ApexBio Technology

Product number: B5752
Product name: CUCPT4a
Packaging: 50mg
Price: $1410
Updated: 2021/12/16

AK Scientific

Product number: 4329DK
Product name: CUCPT4a
Packaging: 1mg
Price: $241
Updated: 2021/12/16

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CU CPT 4a Chemical Properties,Usage,Production

Uses

CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β[1].

Biological Activity

cu cpt 4a is a selective tlr3 inhibitor with ic50 of 3.44 μm in raw 264.7 cells. it can inhibit tlr3/dsrna complex-mediated downstream signaling pathways and inhibit the production of tnf-α and il-1β in whole cells. it reduces the mortality of crypt cells in mice and reduces gastrointestinal syndrome.[1]. cheng k, wang x, yin h. small-molecule inhibitors of the tlr3/dsrna complex. journal of the american chemical society, 2011, 133(11): 3764-3767.[2]. blockade of tlr3 protects mice from lethal radiation-induced gastrointestinal syndrome. nature communications, 2014, 5.

IC 50

TLR3: 3.44 μM (IC₅₀, in RAW 264.7 cells)

storage

Store at +4°C

References

[1] Yibo Wang, et al. Small-Molecule Modulators of Toll-like Receptors. Acc Chem Res. 2020 May 19;53(5):1046-1055. DOI:10.1021/acs.accounts.9b00631

CU CPT 4a Preparation Products And Raw materials

Raw materials

Preparation Products

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CU CPT 4a Suppliers

China 42 United Kingdom 1 United States 6 Global 49

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4769
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
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Beijing Solarbio Science & Tecnology Co., Ltd.

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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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MedBioPharmaceutical Technology Inc

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Shanghai Taopu Industrial Co., LTD

Tel: 00573766 18018507602
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1279713-77-7, CU CPT 4aRelated Search:

CU CPT 4a

N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine

D-Phenylalanine, N-[(3-chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-

TLR3-IN-1

TLR3/dsRNA complex,inhibit,CU-CPT 4a,TNF-α,protein-RNA interaction,IL-1β,TLR-3-IN-1,Inhibitor,TLR3 IN 1,TLR3IN1,Toll-like Receptor (TLR)

(3-Chloro-6-fluorobenzo[b]thiophene-2-carbonyl)-D-phenylalanine

TLR3-IN-1, 10 mM in DMSO

1279713-77-7