ChemicalBook > CAS DataBase List > Formononetin

Formononetin

Product Name
Formononetin
CAS No.
485-72-3
Chemical Name
Formononetin
Synonyms
7-hydroxy-3-(4-Methoxyphenyl)-4H-chroMen-4-one;ForMonentin;Formononetine;Formononetin (50 mg);Myconate;Flavosil;Mycotech;biocanin;NSC 93360;NEOCHANIN
CBNumber
CB0331896
Molecular Formula
C16H12O4
Formula Weight
268.26
MOL File
485-72-3.mol
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Formononetin Property

Melting point:
256-260 °C
Boiling point:
331.43°C (rough estimate)
Density 
1.1529 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.4350 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 100 mg/ml).
pka
6.99±0.20(Predicted)
form 
Powder
color 
White to light beige
λmax
300nm(EtOH)(lit.)
Merck 
14,4244
BRN 
237979
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey
HKQYGTCOTHHOMP-UHFFFAOYSA-N
LogP
1.7 at 25℃
CAS DataBase Reference
485-72-3(CAS DataBase Reference)
EPA Substance Registry System
4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (485-72-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-36
WGK Germany 
3
RTECS 
DJ3100114
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
47752
Product name
Formononetin
Purity
≥99.0% (TLC)
Packaging
5mg
Price
$133
Updated
2024/03/01
Sigma-Aldrich
Product number
47752
Product name
Formononetin
Purity
≥99.0% (TLC)
Packaging
25mg
Price
$489
Updated
2024/03/01
Sigma-Aldrich
Product number
344215
Product name
Formononetin
Purity
A phytoestrogenic isoflavone found in soy-based foods.
Packaging
5mg
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
1286060
Product name
Formononetin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$1070
Updated
2024/03/01
TCI Chemical
Product number
F0868
Product name
Formononetin
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$133
Updated
2024/03/01
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Formononetin Chemical Properties,Usage,Production

Description

Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1?Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2?Accelerates wound repair by increasing expression of Egr-1 transcription factor.3?Potential cancer chemopreventive and chemotherapeutic.4?Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5

Chemical Properties

off-white powder

Uses

An isoflavone found in a variety of plants. When metabolized in the rumen this compound transforms into a potent estrogen.

Uses

Formononetin is an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen.

Uses

Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein . It acts as an agonist of the aryl hydrocarbon receptor with an EC50 value of 0.13 μM. Formononetin has been reported to possess antitumor and antiviral activity.

Definition

ChEBI: Formononetin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'. It has a role as a phytoestrogen and a plant metabolite. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It is functionally related to a daidzein. It is a conjugate acid of a formononetin(1-).

General Description

Formononetin belongs to the isoflavones class of polyphenols.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Isoflavone found in red clover. Effective against Giardia lamblia infection, at least partially by inducing detachment of trophozoites from intestinal mucosa.

References

1) Nie?et al.?(2018),?The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity; Br. J. Pharmacol.,?175?1439 2) Gautam?et al.?(2017),?Formononetin, an isoflavone, activates AMO-activated protein kinase/?β-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss; Br. J. Nutrit.,?117?645 3) Huh?et al. (2011),?Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways; Int. Immunopharmacol.,?11?46 4) Ong?et al.?(2019),?Focus on Formononetin: Anticancer Potential and Molecular Targets; Cancers (Basel),?11?E611 5) Li?et al.?(2018),?Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons; Biomed. Pharmacother.,?106?349

Formononetin Preparation Products And Raw materials

Raw materials

Preparation Products

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Formononetin Suppliers

Nanjing Shangshu Biotechnology Co., Ltd
Tel
18266960953 18266960953
Email
907697096@qq.com
Country
China
ProdList
3033
Advantage
58
Nanjing jingzhu bio-technology Co.,Ltd
Tel
025-52794219 13140719234
Email
2498234449@qq.com
Country
China
ProdList
74
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
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View Lastest Price from Formononetin manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Formononetin Powder 485-72-3
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-18
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Formononetin 485-72-3
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-20
Hebei Weibang Biotechnology Co., Ltd
Product
Formononetin 485-72-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-08

485-72-3, FormononetinRelated Search:


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