Formononetin
- Product Name
- Formononetin
- CAS No.
- 485-72-3
- Chemical Name
- Formononetin
- Synonyms
- 7-hydroxy-3-(4-Methoxyphenyl)-4H-chroMen-4-one;ForMonentin;Formononetine;Formononetin (50 mg);Myconate;Flavosil;Mycotech;biocanin;NSC 93360;NEOCHANIN
- CBNumber
- CB0331896
- Molecular Formula
- C16H12O4
- Formula Weight
- 268.26
- MOL File
- 485-72-3.mol
Formononetin Property
- Melting point:
- 256-260 °C
- Boiling point:
- 331.43°C (rough estimate)
- Density
- 1.1529 (rough estimate)
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.4350 (estimate)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 100 mg/ml).
- pka
- 6.99±0.20(Predicted)
- form
- Powder
- color
- White to light beige
- λmax
- 300nm(EtOH)(lit.)
- Merck
- 14,4244
- BRN
- 237979
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
- InChIKey
- HKQYGTCOTHHOMP-UHFFFAOYSA-N
- LogP
- 1.7 at 25℃
- CAS DataBase Reference
- 485-72-3(CAS DataBase Reference)
- EPA Substance Registry System
- 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (485-72-3)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
- RTECS
- DJ3100114
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 47752
- Product name
- Formononetin
- Purity
- ≥99.0% (TLC)
- Packaging
- 5mg
- Price
- $133
- Updated
- 2024/03/01
- Product number
- 47752
- Product name
- Formononetin
- Purity
- ≥99.0% (TLC)
- Packaging
- 25mg
- Price
- $489
- Updated
- 2024/03/01
- Product number
- 344215
- Product name
- Formononetin
- Purity
- A phytoestrogenic isoflavone found in soy-based foods.
- Packaging
- 5mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- 1286060
- Product name
- Formononetin
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 50mg
- Price
- $1070
- Updated
- 2024/03/01
- Product number
- F0868
- Product name
- Formononetin
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $133
- Updated
- 2024/03/01
Formononetin Chemical Properties,Usage,Production
Description
Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1?Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2?Accelerates wound repair by increasing expression of Egr-1 transcription factor.3?Potential cancer chemopreventive and chemotherapeutic.4?Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5
Chemical Properties
off-white powder
Uses
An isoflavone found in a variety of plants. When metabolized in the rumen this compound transforms into a potent estrogen.
Uses
Formononetin is an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen.
Uses
Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein . It acts as an agonist of the aryl hydrocarbon receptor with an EC50 value of 0.13 μM. Formononetin has been reported to possess antitumor and antiviral activity.
Definition
ChEBI: Formononetin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'. It has a role as a phytoestrogen and a plant metabolite. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It is functionally related to a daidzein. It is a conjugate acid of a formononetin(1-).
General Description
Formononetin belongs to the isoflavones class of polyphenols.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Isoflavone found in red clover. Effective against Giardia lamblia infection, at least partially by inducing detachment of trophozoites from intestinal mucosa.
References
1) Nie?et al.?(2018),?The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity; Br. J. Pharmacol.,?175?1439 2) Gautam?et al.?(2017),?Formononetin, an isoflavone, activates AMO-activated protein kinase/?β-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss; Br. J. Nutrit.,?117?645 3) Huh?et al. (2011),?Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways; Int. Immunopharmacol.,?11?46 4) Ong?et al.?(2019),?Focus on Formononetin: Anticancer Potential and Molecular Targets; Cancers (Basel),?11?E611 5) Li?et al.?(2018),?Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons; Biomed. Pharmacother.,?106?349
Formononetin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Formononetin manufacturers
- Product
- Formononetin 485-72-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 10000ton
- Release date
- 2024-04-24
- Product
- Formononetin 485-72-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- ≥98%HPLC
- Supply Ability
- 20tons
- Release date
- 2024-01-05
- Product
- Formononetin 485-72-3
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- HPLC>99%
- Supply Ability
- Inquiry
- Release date
- 2022-09-16