ChemicalBook > CAS DataBase List > Formononetin

Formononetin

Product Name
Formononetin
CAS No.
485-72-3
Chemical Name
Formononetin
Synonyms
7-hydroxy-3-(4-Methoxyphenyl)-4H-chroMen-4-one;ForMonentin;Formononetine;Formononetin (50 mg);Myconate;Flavosil;Mycotech;biocanin;NSC 93360;NEOCHANIN
CBNumber
CB0331896
Molecular Formula
C16H12O4
Formula Weight
268.26
MOL File
485-72-3.mol
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Formononetin Property

Melting point:
256-260 °C
Boiling point:
331.43°C (rough estimate)
Density 
1.1529 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.4350 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 100 mg/ml).
form 
Powder
pka
6.99±0.20(Predicted)
color 
White to light beige
λmax
300nm(EtOH)(lit.)
Merck 
14,4244
BRN 
237979
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey
HKQYGTCOTHHOMP-UHFFFAOYSA-N
LogP
1.7 at 25℃
CAS DataBase Reference
485-72-3(CAS DataBase Reference)
EPA Substance Registry System
4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (485-72-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-36
WGK Germany 
3
RTECS 
DJ3100114
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
47752
Product name
Formononetin
Purity
≥99.0% (TLC)
Packaging
5mg
Price
$133
Updated
2024/03/01
Sigma-Aldrich
Product number
47752
Product name
Formononetin
Purity
≥99.0% (TLC)
Packaging
25mg
Price
$489
Updated
2024/03/01
Sigma-Aldrich
Product number
344215
Product name
Formononetin
Purity
A phytoestrogenic isoflavone found in soy-based foods.
Packaging
5mg
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
1286060
Product name
Formononetin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$1070
Updated
2024/03/01
TCI Chemical
Product number
F0868
Product name
Formononetin
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$133
Updated
2024/03/01
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Formononetin Chemical Properties,Usage,Production

Description

Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1?Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2?Accelerates wound repair by increasing expression of Egr-1 transcription factor.3?Potential cancer chemopreventive and chemotherapeutic.4?Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5

Chemical Properties

off-white powder

Uses

An isoflavone found in a variety of plants. When metabolized in the rumen this compound transforms into a potent estrogen.

Uses

Formononetin is an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen.

Uses

Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein . It acts as an agonist of the aryl hydrocarbon receptor with an EC50 value of 0.13 μM. Formononetin has been reported to possess antitumor and antiviral activity.

Definition

ChEBI: Formononetin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'. It has a role as a phytoestrogen and a plant metabolite. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It is functionally related to a daidzein. It is a conjugate acid of a formononetin(1-).

General Description

Formononetin belongs to the isoflavones class of polyphenols.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Isoflavone found in red clover. Effective against Giardia lamblia infection, at least partially by inducing detachment of trophozoites from intestinal mucosa.

References

1) Nie?et al.?(2018),?The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity; Br. J. Pharmacol.,?175?1439 2) Gautam?et al.?(2017),?Formononetin, an isoflavone, activates AMO-activated protein kinase/?β-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss; Br. J. Nutrit.,?117?645 3) Huh?et al. (2011),?Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways; Int. Immunopharmacol.,?11?46 4) Ong?et al.?(2019),?Focus on Formononetin: Anticancer Potential and Molecular Targets; Cancers (Basel),?11?E611 5) Li?et al.?(2018),?Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons; Biomed. Pharmacother.,?106?349

Formononetin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Formononetin manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
Formononetin 485-72-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-26
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Formononetin 485-72-3
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-20
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Formononetin Powder 485-72-3
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-18

485-72-3, FormononetinRelated Search:

METHYL THIOPHENE-2-CARBOXYLATE Methylparaben 4-Methoxyphenylacetone Bensulfuron methyl (Trifluoromethoxy)benzene Thiophanate-methyl DIPHENYLCYCLOPROPENONE CHROMONE 4'-Hydroxyacetophenone Methyl acrylate 2'-Hydroxyacetophenone CHLOROPHOSPHONAZO III Breviscapinun Kresoxim-methyl Methyl 4',7-Dimethoxyisoflavone 4',6,7-Trimethoxyisoflavone 5,7-Dihydrox -4'-methoxyisoflavone

  • Formononetin (50 mg)
  • red clover extract_formononetin
  • Flavosil
  • ForMonentin
  • Myconate
  • NSC 93360
  • ForMononetin (ForMononetol)
  • ForMoononetin
  • 7-Hydroxy-3-(4-methoxyphenyl)chromone, 7-Hydroxy-4μ-methoxyisoflavone
  • Formononetin，Formoononetin
  • 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)-
  • Daidzein 4'-methyl ether
  • Formononetin ,98%
  • 4'-Methoxy-7-hydroxyisoflavone
  • 7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
  • Formononetin,99%
  • Mycotech
  • 7-hydroxy-3-(4-Methoxyphenyl)-4H-chroMen-4-one
  • forMonoetin
  • ForMononetin, 99% 1GR
  • ForMononetin SynonyMs 7-Hydroxy-3-(4-Methoxyphenyl)chroMone
  • Trifolium pratensel L
  • 7-hydroxy-3-(4-methoxyphenyl)-1-benzopyran-4-one
  • Formononetin 7-Hydroxy-3-(4-methoxyphenyl)chromone
  • NEOCHANIN
  • 7-HYDROXY-3-(4'-METHOXYPHENYL)-4H-BENZOPYRAN-4-ONE
  • 7-HYDROXY-3-(4-METHOXYPHENYL)CHROMEN-4-ONE
  • 7-HYDROXY-3-(4-METHOXYPHENYL)CHROMONE
  • 7-HYDROXY-4'-METHOXYISOFLAVANONE
  • 7-HYDROXY-4'-METHOXYISOFLAVONE
  • 7-HYDROXY-4'-METHOXYUSIFLAVONE
  • AKOS BBS-00006073
  • BIOCHANIN B
  • DADEIN 4'-METHYL ETHER
  • FORMONONETIN
  • FORMONONETOL
  • 7-hydroxy-3-(4-methoxyphenyl)-4-benzopyrone
  • Formononetin by synthesis
  • FORMONONETIN 99%
  • BiocaninB
  • Formononetine
  • FORMONETIN
  • 7-Hydroxy-3-(4-methoxyphenyl)chromone, 7-Hydroxy-3-(4-methoxyphenyl)chromone
  • FORMONONETIN WITH HPLC
  • FORMONONETIN, NATURAL
  • Formononetin 98.0%min
  • 3-(4-methoxyphenyl)-
  • FORMONONETIN hplc
  • Formononetin 485-72-3
  • Formononetin - CAS 485-72-3 - Calbiochem
  • Formononetin, 98%, reagent grade
  • Formononetin&gt
  • FPRMONONETIN
  • 7-Hydroxy-4'-methoxyisoflavone (Formononetin)
  • Formononetin (Biochanin B)
  • Formononetin (1286060)
  • biocanin
  • 7- Hydroxy -4'- methoxy Isoflavone (or ) Formonetin