2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL

Product Name: 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL
CAS No.: 5197-62-6
Chemical Name: 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL
Synonyms: 8-Chloro-3,6-dioxaoctane-1-ol;2-[2-(2-Chloroethoxy)ethoxy]ethanol,95%;CEEE;NSC 2636;8-Chloro-3,6-dioxaoctanol;Chloroethoxyethoxy]ethanol;8-Chloro-3,6-dioxa-1-octanol;2-Chloroethoxy Ethoxy Ethanol;2-(2-CHLOROETHOXY)ETHOXYETHANOL;Triethylene glycol monochloride
CBNumber: CB0333360
Molecular Formula: C6H13ClO3
Formula Weight: 168.62
MOL File: 5197-62-6.mol

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2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL Property

Boiling point:: 117-120 °C5 mm Hg(lit.)
Density: 1.16 g/mL at 25 °C(lit.)
refractive index: n20/D 1.458(lit.)
Flash point:: 225 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly)
pka: 14.36±0.10(Predicted)
form: Liquid
color: Clear slightly yellow
BRN: 1739194
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents.
InChI: InChI=1S/C6H13ClO3/c7-1-3-9-5-6-10-4-2-8/h8H,1-6H2
InChIKey: KECMLGZOQMJIBM-UHFFFAOYSA-N
SMILES: C(O)COCCOCCCl
CAS DataBase Reference: 5197-62-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HS Code: 29094990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 162973
Product name: 2-[2-(2-Chloroethoxy)ethoxy]ethanol
Purity: 96%
Packaging: 10g
Price: $49.42
Updated: 2025/07/31

TCI Chemical

Product number: C1416
Product name: 2-[2-(2-Chloroethoxy)ethoxy]ethanol
Purity: >96.0%(GC)
Packaging: 25g
Price: $52
Updated: 2025/07/31

TCI Chemical

Product number: C1416
Product name: 2-[2-(2-Chloroethoxy)ethoxy]ethanol
Purity: >96.0%(GC)
Packaging: 100g
Price: $131
Updated: 2025/07/31

TCI Chemical

Product number: C1416
Product name: 2-[2-(2-Chloroethoxy)ethoxy]ethanol
Purity: >96.0%(GC)
Packaging: 500g
Price: $393
Updated: 2025/07/31

TRC

Product number: C365760
Product name: 2-[2-(2-Chloroethoxy)ethoxy]ethanol
Packaging: 50g
Price: $475
Updated: 2021/12/16

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2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

2-[2-(2-Chloroethoxy)ethoxy]ethanol is used in the preparation of ethylene glycol based amino acids. 2-[2-(2-Chloroethoxy)ethoxy]ethanol is also used in the preparation of polymers for direct and amplified DNA detection.

Uses

2-[2-(2-Chloroethoxy)ethoxy]ethanol was used in the synthesis of 1-[3-(2-aminoethyl)-1H-indol-5-yloxy]-3,6-dioxa-8-mercaptooctane. It was also used in the synthesis of modified oligonucleotides bearing a disulfide or a thiol function at the 3′-end and other modifications at the 5′-end.

Synthesis

75-21-8

628-89-7

5197-62-6

The reaction material in the three-necked flask was cooled to 45-50°C and 0.7 g of boron trifluoride diethyl ether compound was added as catalyst. Subsequently, 46.2 g (1.05 mol) of ethylene oxide was slowly added under stirring conditions, and the addition rate was controlled to maintain the reaction temperature at 45-55°C, using a temperature-controlled water bath for temperature adjustment if necessary. After the addition, the reaction was continued with stirring for 0.5 h to ensure complete reaction. Upon completion of the reaction, the reaction was heated and distilled under reduced pressure to collect the middle fraction at 115-123°C (vacuum 10 mmHg) to obtain a colorless transparent liquid. Further vacuum distillation was carried out under reduced pressure to collect the middle fraction at 118-121 °C (vacuum 10 mmHg) to give 123.6 g of colorless transparent liquid with 97.7% purity in the gas phase and 73.3% overall yield.

References

[1] Patent: CN104003850, 2016, B. Location in patent: Paragraph 0039; 0040

2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL Suppliers

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View Lastest Price from 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL manufacturers

Shanxi Naipu Import and Export Co.,Ltd

Product: 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL 5197-62-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000kg/month
Release date: 2021-10-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL 5197-62-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL 5197-62-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-24

5197-62-6, 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOLRelated Search:

2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL α-Chloralose BETA-CHLORALOSE DIETHYLENE GLYCOL BIS(2-CHLOROETHYL) ETHER 1-(2-CHLORO-ETHOXY)-2-(2-METHOXY-ETHOXY)-ETHANE [2-(2-METHOXY-ETHOXY)-ETHOXY]-ACETYL CHLORIDE 1,2,3-TRI-O-BENZOYL-A-L-FUCOPYRANOSE, TRICHLOROACETIMIDATE 2-(2-hydroxyethoxy)ethyl chloroacetate 1-[2-HYDROXY-7-(TRICHLOROMETHYL)-4,6,8-TRIOXABICYCLO[3.3.0]OCT-3-YL]ETHANE-1,2-DIOL 3,4,6-TRI-O-ACETYL-2-O-(2',3',4'-TRI-O-BENZOYL-A-L-FUCOPYRANOSYL)-GALACTOPYRANOSYL TRICHLOROACETIMIDATE 5-CHLOROACETOXY-2-BENZYLOXYISOSORBIDE amicloral AURORA KA-6932 LABOTEST-BB LT00455823 METHYL (2-O-BETA-D-GLUCOPYRANOSYL)-4,6-DICHLORO-ALPHA-D-GALACTOPYRANOSIDE AURORA KA-6933 6-CHLORO-2,2-DIMETHYLPERHYDRO[1,3]DIOXOLO[4',5':4,5]FURO[3,2-B]PYRAN-5-ONE LABOTEST-BB LT00112361

8-Chloro-3,6-dioxaoctane-1-ol

Diethylene glycol mono(2-chloroethyl) ether

2-[2-(2-Chloroethoxy)ethoxy]ethanol,95%

8-Chloro-3,6-dioxa-1-octanol

8-Chloro-3,6-dioxaoctanol

NSC 2636

2-[2-(2-Chloroethoxy)ethoxy]ethanol 96%

2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL

2-(2-CHLOROETHOXY)ETHOXYETHANOL

TRIETHYLENE GLYCOL MONOCHLOROHYDRIN

Triethylene glycol monochloride

2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL, 96+%

Chloroethoxyethoxy]ethanol

CEEE

2-[2-(2-Chloroethoxy)ethoxy]ethanol &gt

Ethanol, 2-[2-(2-chloroethoxy)ethoxy]-

2-Chloroethoxy Ethoxy Ethanol

2-[2-(2-chloroethoxy)ethoxy]ethan-1-ol

2-Chloroethoxy-2-ethoxydiethanol

5197-62-6

C6H13ClO3

ClCH2CH2O2CH2CH2OH

Monofunctional Ethylene Glycols

Ethylene Glycols & Monofunctional Ethylene Glycols

Organic Building Blocks

Oxygen Compounds

C2 to C6

Alcohols

Building Blocks

Aliphatics

Intermediates

Polyethyleneglycol Derivatives

Ethylene Glycols & Monofunctional Ethylene Glycols

Monofunctional Ethylene Glycols