2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL
- Product Name
- 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL
- CAS No.
- 5197-62-6
- Chemical Name
- 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL
- Synonyms
- 8-Chloro-3,6-dioxaoctane-1-ol;2-[2-(2-Chloroethoxy)ethoxy]ethanol,95%;CEEE;NSC 2636;8-Chloro-3,6-dioxaoctanol;Chloroethoxyethoxy]ethanol;8-Chloro-3,6-dioxa-1-octanol;2-Chloroethoxy Ethoxy Ethanol;2-(2-CHLOROETHOXY)ETHOXYETHANOL;Triethylene glycol monochloride
- CBNumber
- CB0333360
- Molecular Formula
- C6H13ClO3
- Formula Weight
- 168.62
- MOL File
- 5197-62-6.mol
2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL Property
- Boiling point:
- 117-120 °C5 mm Hg(lit.)
- Density
- 1.16 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.458(lit.)
- Flash point:
- 225 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly)
- pka
- 14.36±0.10(Predicted)
- form
- Liquid
- color
- Clear slightly yellow
- BRN
- 1739194
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- InChI
- InChI=1S/C6H13ClO3/c7-1-3-9-5-6-10-4-2-8/h8H,1-6H2
- InChIKey
- KECMLGZOQMJIBM-UHFFFAOYSA-N
- SMILES
- C(O)COCCOCCCl
- CAS DataBase Reference
- 5197-62-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HS Code
- 29094990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 162973
- Product name
- 2-[2-(2-Chloroethoxy)ethoxy]ethanol
- Purity
- 96%
- Packaging
- 10g
- Price
- $49.42
- Updated
- 2025/07/31
- Product number
- C1416
- Product name
- 2-[2-(2-Chloroethoxy)ethoxy]ethanol
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- C1416
- Product name
- 2-[2-(2-Chloroethoxy)ethoxy]ethanol
- Purity
- >96.0%(GC)
- Packaging
- 100g
- Price
- $131
- Updated
- 2025/07/31
- Product number
- C1416
- Product name
- 2-[2-(2-Chloroethoxy)ethoxy]ethanol
- Purity
- >96.0%(GC)
- Packaging
- 500g
- Price
- $393
- Updated
- 2025/07/31
- Product number
- C365760
- Product name
- 2-[2-(2-Chloroethoxy)ethoxy]ethanol
- Packaging
- 50g
- Price
- $475
- Updated
- 2021/12/16
2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL Chemical Properties,Usage,Production
Chemical Properties
colourless liquid
Uses
2-[2-(2-Chloroethoxy)ethoxy]ethanol is used in the preparation of ethylene glycol based amino acids. 2-[2-(2-Chloroethoxy)ethoxy]ethanol is also used in the preparation of polymers for direct and amplified DNA detection.
Uses
2-[2-(2-Chloroethoxy)ethoxy]ethanol was used in the synthesis of 1-[3-(2-aminoethyl)-1H-indol-5-yloxy]-3,6-dioxa-8-mercaptooctane. It was also used in the synthesis of modified oligonucleotides bearing a disulfide or a thiol function at the 3′-end and other modifications at the 5′-end.
Synthesis
75-21-8
628-89-7
5197-62-6
The reaction material in the three-necked flask was cooled to 45-50°C and 0.7 g of boron trifluoride diethyl ether compound was added as catalyst. Subsequently, 46.2 g (1.05 mol) of ethylene oxide was slowly added under stirring conditions, and the addition rate was controlled to maintain the reaction temperature at 45-55°C, using a temperature-controlled water bath for temperature adjustment if necessary. After the addition, the reaction was continued with stirring for 0.5 h to ensure complete reaction. Upon completion of the reaction, the reaction was heated and distilled under reduced pressure to collect the middle fraction at 115-123°C (vacuum 10 mmHg) to obtain a colorless transparent liquid. Further vacuum distillation was carried out under reduced pressure to collect the middle fraction at 118-121 °C (vacuum 10 mmHg) to give 123.6 g of colorless transparent liquid with 97.7% purity in the gas phase and 73.3% overall yield.
References
[1] Patent: CN104003850, 2016, B. Location in patent: Paragraph 0039; 0040
2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL Suppliers
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View Lastest Price from 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL manufacturers
- Product
- 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL 5197-62-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000kg/month
- Release date
- 2021-10-19
- Product
- 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL 5197-62-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL 5197-62-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-24