ChemicalBook > CAS DataBase List > KDOAM-25
KDOAM-25
- Product Name
- KDOAM-25
- CAS No.
- 2230731-99-2
- Chemical Name
- KDOAM-25
- Synonyms
- KDOAM-25;KDOAM 25,KDOAM25;KDOAM-25 trihydrochloride;4-Pyridinecarboxamide, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-
- CBNumber
- CB03339897
- Molecular Formula
- C15H25N5O2
- Formula Weight
- 307.39
- MOL File
- 2230731-99-2.mol
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KDOAM-25 Property
- Boiling point:
- 478.6±45.0 °C(Predicted)
- Density
- 1.137±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- pka
- 15.03±0.50(Predicted)
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KDOAM-25 Chemical Properties,Usage,Production
Biochem/physiol Actions
KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. JARID1A and JARID1B are independently overexpressed in some cancers with JARID1B (KDM5B, PLU1) also identified as a potential oncogene, a repressor of tumour repressor genes. JARID1C (KDM5C) and JARID1D (KDM5D) are located on the X- and Y-chromosomes respectively. KDOAM25′s closest off-target is JMJD2C (selectivity >400 fold). It shows no activity on other tested 2-OG family members, including FIH, NO66, MINA53 and PHD2. KDOAM25 is active in cells.
KDOAM-25 Preparation Products And Raw materials
Raw materials
Preparation Products
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KDOAM-25 Suppliers
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- +1-781-999-5354 +1-00000000000
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