TCO-PEG4-NHS Ester
- Product Name
- TCO-PEG4-NHS Ester
- CAS No.
- 1621096-79-4
- Chemical Name
- TCO-PEG4-NHS Ester
- Synonyms
- TCO4-PEG4-NHS;(E)-TCO-PEG4-NHS ester;TCO-PEG4-NHS Ester (CCT-A137);TCO-PEG4-NHS Ester,Trans-Cyclooctene-PEG4-NHS ester;TCO-PEG4-NHS(contains 6% Dichloromethane at maximum);(E)-2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4E)-4-cycloocten-1-yl 17-(2,5-dioxo-1-pyrrolidinyl) ester
- CBNumber
- CB03345120
- Molecular Formula
- C24H38N2O10
- Formula Weight
- 514.57
- MOL File
- 1621096-79-4.mol
TCO-PEG4-NHS Ester Property
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Storage temp. -20°C
- solubility
- DMSO, DMF, THF, DCM, Acetonitrile
- pka
- 11.95±0.46(Predicted)
- form
- Oil
- color
- Colorless to light yellow
- Appearance
- colorless syrup
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H316Causes mild skin irritation
H341Suspected of causing genetic defects
H350May cause cancer
H371May cause damage to organs
H373May cause damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T3949
- Product name
- TCO-PEG4-NHS (contains 6% Dichloromethane at maximum)
- Packaging
- 25MG
- Price
- $369
- Updated
- 2025/07/31
- Product number
- 35081
- Product name
- TCO-PEG4-NHSester,95%(HPLC)
- Purity
- 95%(HPLC)
- Packaging
- 5MG
- Price
- $145.6
- Updated
- 2021/12/16
- Product number
- 35081
- Product name
- TCO-PEG4-NHSester,95%(HPLC)
- Purity
- 95%(HPLC)
- Packaging
- 25MG
- Price
- $308
- Updated
- 2021/12/16
- Product number
- TCO1010
- Product name
- TCO-PEG(4)-NHS
- Packaging
- 25mg
- Price
- $607.5
- Updated
- 2021/12/16
- Product number
- 35081
- Product name
- TCO-PEG4-NHSester,95%(HPLC)
- Purity
- 95%(HPLC)
- Packaging
- 100MG
- Price
- $627.2
- Updated
- 2021/12/16
TCO-PEG4-NHS Ester Chemical Properties,Usage,Production
Description
TCO-PEG4-NHS ester is a bifunctional linker with trans-cyclooctene (TCO) and NHS ester groups flanking PEG4 (tetraethylene glycol).
The PEG spacer increases solubility in aqueous media and provides a long and flexible connection that minimizes steric hindrance involved with ligation.
The amine-reactive N-hydroxysuccinimide residue provides easy attachment to almost any primary or secondary amine group, such as protein, peptide, or small molecule amine.
Trans-cyclooctene readily reacts with tetrazines via inverse electron-demand Diels-Alder cycloaddition (IEDDA). TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, and long-term aqueous stability, which is important in low-concentration applications such as protein-protein conjugations, etc.
Uses
TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
IC 50
PEGs
References
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1013. DOI:10.1016/j.chembiol.2020.07.021
TCO-PEG4-NHS Ester Preparation Products And Raw materials
Raw materials
Preparation Products
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