(4E)-TCO-PEG3-amine

Product Name: (4E)-TCO-PEG3-amine
CAS No.: 1800507-93-0
Chemical Name: (4E)-TCO-PEG3-amine
Synonyms: TCO4-PEG3-NH2;(4E)-TCO-PEG3-amine;TCO-PEG3-Amine,TCO-PEG3-NH2,;cyclooct-4-en-1-yl N-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethyl)carbamate;5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, (4E)-4-cycloocten-1-yl ester
CBNumber: CB94849383
Molecular Formula: C17H32N2O5
Formula Weight: 344.45
MOL File: 1800507-93-0.mol

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(4E)-TCO-PEG3-amine Property

Boiling point:: 483.4±45.0 °C(Predicted)
Density: 1.08±0.1 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF
pka: 11.95±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24099
Product name: TCO-PEG3-amine
Purity: 95%
Packaging: 100mg
Price: $560
Updated: 2021/12/16

BroadPharm

Product number: BP-24099
Product name: TCO-PEG3-amine
Purity: 95%
Packaging: 250mg
Price: $1100
Updated: 2021/12/16

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(4E)-TCO-PEG3-amine Chemical Properties,Usage,Production

Description

TCO-PEG3-amine is a click chemistry building block containing a TCO moiety and a free amine. Amine is very reactive with active NHS ester or with carboxylic acid in the presence of of activators suh as EDC. TCO moiety is very reactive with tetrazine ( 3rd generation click chemistry).

Uses

TCO-PEG3-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001

(4E)-TCO-PEG3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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(4E)-TCO-PEG3-amine Suppliers

China 19 United States 2 Global 21

Changzhou Hopschain Chemical Co.,Ltd.

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1800507-93-0, (4E)-TCO-PEG3-amineRelated Search:

TCO4-PEG3-Maleimide (2E)-TCO-PNB ester TCO-PEG4-NHS ester (4E)-TCO-PEG4-DBCO (4E)-TCO-amine TCO-PEG4-Acid BDP FL-PEG4-(4E)-TCO trans-Cyclooctene-maleimide (4E)-TCO-PEG4-amine TCO-PEG3-Amine TCO-carbonate TCO/E- active ester (p-NPE) / equatorial TCO-PEG4-NHS Ester TCO4-PEG3-NHS TCO-PEG3-acid TCO4-PEG7-NH2 Sulfo-Cy5-(4E)-TCO TCO4-PEG7-Maleimide

(4E)-TCO-PEG3-amine

TCO4-PEG3-NH2

TCO-PEG3-Amine,TCO-PEG3-NH2,

5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, (4E)-4-cycloocten-1-yl ester

cyclooct-4-en-1-yl N-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethyl)carbamate

1800507-93-0

SiChem