TCO-carbonate

Product Name: TCO-carbonate
CAS No.: 1191901-33-3
Chemical Name: TCO-carbonate
Synonyms: TCO-NHS;TCO-carbonate;TCO-NHS ester;(4E)-TCO-NHS ester;1191901-33-3(Mixture);TCONHS ester,TCO NHS ester;TCO-N-hydroxysuccinimidyl carbonate;TCO4 - NHS carbonate / AXIAL isomer;TCO-NHS Ester (equatorial) (CCT-1016);TCO4 - NHS carbonate / EQUATORIAL isomer
CBNumber: CB12755772
Molecular Formula: C13H17NO5
Formula Weight: 267.28
MOL File: 1191901-33-3.mol

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TCO-carbonate Property

Melting point:: 90-105°C
Boiling point:: 369.1±45.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO
form: Solid
color: White to off-white
InChI: InChI=1S/C13H17NO5/c15-11-8-9-12(16)14(11)19-13(17)18-10-6-4-2-1-3-5-7-10/h1-2,10H,3-9H2/b2-1+
InChIKey: OUGQJOKGFAIFAQ-OWOJBTEDSA-N
SMILES: C(ON1C(=O)CCC1=O)(=O)OC1CCCC=CCC1 |t:16|

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 764523
Product name: (E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate
Packaging: 1mg
Price: $79.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 764523
Product name: (E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate
Packaging: 5mg
Price: $257
Updated: 2025/07/31

Sigma-Aldrich

Product number: 764523
Product name: (E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate
Packaging: 25mg
Price: $565
Updated: 2025/07/31

TRC

Product number: T126088
Product name: TCO-NHSester
Packaging: 10mg
Price: $200
Updated: 2021/12/16

BroadPharm

Product number: BP-22417
Product name: TCO-NHSester
Purity: 95%
Packaging: 25mg
Price: $145
Updated: 2021/12/16

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TCO-carbonate Chemical Properties,Usage,Production

Description

TCO-NHS Ester is an popular reagent to label amine-containing compound or biomolecule, TCOI enable fast click chemistry with tetrazine.

Uses

Succinimidyl carbonate/NHS functionalized cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.

reaction suitability

reaction type: click chemistry
reagent type: linker

IC 50

Alkyl/ether

TCO-carbonate Preparation Products And Raw materials

Raw materials

Preparation Products

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TCO-carbonate Suppliers

China 90 India 1 United States 6 Global 97

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai URChem Limited

Tel: +86-021-50890968，021-50891159 +86-18601776121
Fax: 086-21-68416099 58604179
Email: danny@urchem.com
Country: China
ProdList: 628
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9274
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

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View Lastest Price from TCO-carbonate manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (4E)-TCO-NHS ester 1191901-33-3
Price: US $0.00/mg
Min. Order: 25mg
Purity: >95.00%
Supply Ability: 25mg
Release date: 2024-03-21

1191901-33-3, TCO-carbonateRelated Search:

TCO-PNB Ester (4E)-TCO-PEG4-amine TCO-PEG3-Amine TCO/E- active ester (p-NPE) / equatorial (4E)-TCO-PEG3-amine (2E)-TCO-PNB ester TCO-PEG4-NHS ester (4E)-TCO-PEG4-DBCO (4E)-TCO-amine TCO-PEG4-Acid BDP FL-PEG4-(4E)-TCO trans-Cyclooctene-maleimide Sulfo-Cy5-(4E)-TCO TCO*-PEG2-NH2 TCO*-PEG4-NHS TCO*-PEG8-COOH TCO*-PEG2-Maleimide TCO*-PEG7-NH2

(E)-4-Cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl ester carbonic acid

(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate

TCO-carbonate

TCO-NHS

TCO-N-hydroxysuccinimidyl carbonate

trans-4-Cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl carbonate

TCO-NHS ester

TCO4 - NHS carbonate / EQUATORIAL isomer

TCO4 - NHS carbonate / AXIAL isomer

(4E)-TCO-NHS ester

TCO-NHS Ester,Trans-Cyclooctene-NHS ester

Carbonic acid, (4E)-4-cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl ester

1191901-33-3(Mixture)

(E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate

TCONHS ester,TCO NHS ester

TCO-NHS/Carbonic acid, (4E)-4-cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl ester

(E)-4-Cycloocten-1-yl (2,5-Dioxo-1-pyrrolidinyl) Carbonate

(4Z)-cyclooct-4-en-1-yl 2,5-dioxopyrrolidin-1-yl carbonate

2,5-dioxopyrrolidin-1-yl (E)-2-(cyclooct-4-en-1-yloxy)acetate

(<i>E</i>)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate

TCO-NHS Ester (equatorial) (CCT-1016)

2,5-dioxopvrrolidin-1-vl(E)-2-(cvclooct-4-en-1-yloxy)acetate

1191901-33-3

119190-33-3

SiChem