(4E)-TCO-PEG4-DBCO
- Product Name
- (4E)-TCO-PEG4-DBCO
- CAS No.
- 1801863-88-6
- Chemical Name
- (4E)-TCO-PEG4-DBCO
- Synonyms
- TCO-PEG4-DBCO;(4E)-TCO-PEG4-DBCO
- CBNumber
- CB84849386
- Molecular Formula
- C38H49N3O8
- Formula Weight
- 675.82
- MOL File
- 1801863-88-6.mol
(4E)-TCO-PEG4-DBCO Property
- Boiling point:
- 891.1±65.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- solubility
- Soluble in Partially Water Soluble, DMSO, DCM, DMF
- pka
- 11.95±0.46(Predicted)
- form
- Oil
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP-24160
- Product name
- TCO-PEG4-DBCO
- Purity
- 95%
- Packaging
- 25mg
- Price
- $350
- Updated
- 2021/12/16
(4E)-TCO-PEG4-DBCO Chemical Properties,Usage,Production
Description
TCO-PEG4-DBCO is a heterobifunctional click chemistry reagent containing a TCO and a DBCO moiety. TCO group specifically and efficiently reacts with terrahydrazine at fast speed. DBCO is very reactive toward Azide through copper free click chemistry, the PEG spacer increases the aqueous solubility of the reagent.
Uses
TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. TCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. TCO-PEG4-DBCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
IC 50
Cleavable Linker; PEGs
References
[1] Rahim MK, et al. Enhancing reactivity for bioorthogonal pretargeting by unmasking antibody-conjugated trans-cyclooctenes. Bioconjug Chem. 2015 Feb 18;26(2):352-60. DOI:10.1021/bc500605g
(4E)-TCO-PEG4-DBCO Preparation Products And Raw materials
Raw materials
Preparation Products
(4E)-TCO-PEG4-DBCO Suppliers
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
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- 39966
- Advantage
- 60
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- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
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- 12306
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- 58
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
- Country
- China
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- 4952
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- 58
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- +1-5166625404;
- Fax
- 1-516-927-0118
- Info@alfa-chemistry.com
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- United States
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- 20405
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
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- United States
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- 32435
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- Tel
- 571-86758373 +8613588754946
- Fax
- 0086-571-81131109
- sales@huarongpharm.com
- Country
- CHINA
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- 3148
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- 58
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- 13892832556
- 2440688701@qq.com
- Country
- China
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- 1994
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- 58
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- 020-82000279 18988941452
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- QQ：3283937693
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- China
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- 13758194781 13173652190
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- Country
- China
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- Tel
- 0371-0371-53736046 13393710386
- Fax
- QQ:2853979814
- 2853979814@qq.com
- Country
- China
- ProdList
- 9947
- Advantage
- 58
View Lastest Price from (4E)-TCO-PEG4-DBCO manufacturers
- Product
- (4E)-TCO-PEG4-DBCO 1801863-88-6
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- >99.00%
- Supply Ability
- 50mg
- Release date
- 2024-03-20