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TCO-PEG4-NHS ester

Product Name
TCO-PEG4-NHS ester
CAS No.
1613439-69-2
Chemical Name
TCO-PEG4-NHS ester
Synonyms
TCO-PEG4-NHS ester;(4E)-TCO-PEG4-NHS ester;2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;(Z)-2,5-dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4-cycloocten-1-yl) 17-(2,5-dioxo-1-pyrrolidinyl) ester
CBNumber
CB93062671
Molecular Formula
C24H38N2O10
Formula Weight
514.57
MOL File
1613439-69-2.mol
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TCO-PEG4-NHS ester Property

Density 
1.23±0.1 g/cm3(Predicted)
solubility 
Soluble in DMSO, DCM, DMF
pka
11.95±0.46(Predicted)
form 
Oil
color 
Colorless to light yellow
InChI
InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1-
InChIKey
ZKPMRASGLDBKPF-UPHRSURJSA-N
SMILES
C(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |c:6|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-22418
Product name
TCO-PEG4-NHSester
Purity
95%
Packaging
10mg
Price
$139
Updated
2021/12/16
BroadPharm
Product number
BP-22418
Product name
TCO-PEG4-NHSester
Purity
95%
Packaging
25mg
Price
$235
Updated
2021/12/16
BroadPharm
Product number
BP-22418
Product name
TCO-PEG4-NHSester
Purity
95%
Packaging
100mg
Price
$575
Updated
2021/12/16
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TCO-PEG4-NHS ester Chemical Properties,Usage,Production

Description

TCO-PEG4-NHS Ester is a click chemistry crosslinker. This reagent can be used to label antibodies, proteins and other primary amine containing molecule. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. TCO enable fast click chemistry under mild condition

Biological Activity

TCO-PEG4-NHS ester is a PROTAC linker and belongs to the PEG class,it can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

TCO-PEG4-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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TCO-PEG4-NHS ester Suppliers

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View Lastest Price from TCO-PEG4-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
(4E)-TCO-PEG4-NHS ester 1613439-69-2
Price
US $0.00/mg
Min. Order
50mg
Purity
>95.00%
Supply Ability
50mg
Release date
2024-03-21

1613439-69-2, TCO-PEG4-NHS esterRelated Search:


  • (4E)-TCO-PEG4-NHS ester
  • TCO-PEG4-NHS ester
  • 5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4-cycloocten-1-yl) 17-(2,5-dioxo-1-pyrrolidinyl) ester
  • (Z)-2,5-dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
  • 2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
  • 1613439-69-2
  • Cleavable

    PEGs