GSK-LSD1 Dihydrochloride

Product Name: GSK-LSD1 Dihydrochloride
CAS No.: 2102933-95-7
Chemical Name: GSK-LSD1 Dihydrochloride
Synonyms: GSK-LSD1 dihydrochloride, 10 mM in DMSO;GSK LSD1 dihydrochloride,Monoamine Oxidase,GSK-LSD-1 dihydrochloride,Inhibitor,inhibit,GSK-LSD1,MAO,GSKLSD1 dihydrochloride,Histone Demethylase
CBNumber: CB03356155
Molecular Formula: C14H21ClN2
Formula Weight: 252.79
MOL File: 2102933-95-7.mol

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GSK-LSD1 Dihydrochloride Property

storage temp.: Store at -20°C
solubility: DMF: 1 mg/ml; DMSO: 25 mg/ml; Ethanol: 0.1 mg/ml; PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16439
Product name: GSK-LSD1 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16439
Product name: GSK-LSD1 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 16439
Product name: GSK-LSD1 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 16439
Product name: GSK-LSD1 (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $343
Updated: 2024/03/01

ChemScene

Product number: CS-7913
Product name: GSK-LSD1(dihydrochloride)
Purity: >98.0%
Packaging: 50mg
Price: $504
Updated: 2021/12/16

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GSK-LSD1 Dihydrochloride Chemical Properties,Usage,Production

Description

Lysine-specific demethylase 1 (LSD1) belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs) and polyamine oxidase (PAO).¹ LSD1 specifically demethylates mono- and dimethylated histone H3 lysine 4, resulting in transcriptional repression.² It also controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS³⁷⁰).³ GSK-LSD1 is an irreversible, mechanism-based inhibitor of LSD1 (IC₅₀ = 16 nM) that is >1,000-fold selective over the closely related FAD-utilizing enzymes LSD2, MAO-A, and MAO-B.⁴ GSK-LSD1 induces gene expression changes in various cancer cell lines, inhibiting their proliferation (EC₅₀s <5 nM).⁴ See the Structural Genomics Consortium (SGC) website for more information.

storage

Store at +4°C

References

1. Shi, Y., Lan, F., Matson, C., et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 Cell 119(7),941-953(2004).
2. Forneris, F., Binda, C., Vanoni, M.A., et al. Human histone demethylase LSD1 reads the histone code J. Biol. Chem. 280(50),41360-41365(2005).
3. Huang, J., Sengupta, R., Espejo, A.B., et al. p53 is regulated by the lysine demethylase LSD1 Nature 449,105-108(2007).
4. Epigenetics probes collection ,(2014).

GSK-LSD1 Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-LSD1 Dihydrochloride Suppliers

China 20 United States 4 Global 24

MedChemexpress LLC

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Beijing xinyanhui pharmaceutical research and development co., LTD

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Shanghai hongqu biomedical technology co. LTD

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Beijing Aomi Jiade Pharmaceutical Technology Co., Ltd

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2102933-95-7, GSK-LSD1 DihydrochlorideRelated Search:

GSK-LSD1 2-Diphenylmethylpiperidine hydrochloride ORY-1001(trans) GSK-LSD1 (hydrochloride) GSK-LSD1 Dihydrochloride

GSK LSD1 dihydrochloride,Monoamine Oxidase,GSK-LSD-1 dihydrochloride,Inhibitor,inhibit,GSK-LSD1,MAO,GSKLSD1 dihydrochloride,Histone Demethylase

GSK-LSD1 dihydrochloride, 10 mM in DMSO

2102933-95-7