inS3-54A18
- Product Name
- inS3-54A18
- CAS No.
- 328998-53-4
- Chemical Name
- inS3-54A18
- Synonyms
- inS3-54A18;CID 1920398;inS3-54A18, 10 mM in DMSO;inS3-54A18,Inhibitor,inS-3-54A18,inS3 54A18,inS354A18,inhibit,STAT;3-(4-Chlorobenzylidene)-1-(4-hydroxyphenyl)-5-phenyl-1,3-dihydro-2H-pyrrol-2-one;2H-Pyrrol-2-one, 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl-
- CBNumber
- CB03356160
- Molecular Formula
- C23H16ClNO2
- Formula Weight
- 373.83
- MOL File
- 328998-53-4.mol
inS3-54A18 Property
- Boiling point:
- 630.5±55.0 °C(Predicted)
- Density
- 1.363±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 150 mg/mL (401.25 mM)
- form
- Solid
- pka
- 10.05±0.30(Predicted)
- color
- Yellow to orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-7550
- Product name
- inS3-54A18
- Purity
- 99.83%
- Packaging
- 2mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- CS-7550
- Product name
- inS3-54A18
- Purity
- 99.83%
- Packaging
- 5mg
- Price
- $192
- Updated
- 2021/12/16
- Product number
- CS-7550
- Product name
- inS3-54A18
- Purity
- 99.83%
- Packaging
- 10mg
- Price
- $312
- Updated
- 2021/12/16
- Product number
- CS-7550
- Product name
- inS3-54A18
- Purity
- 99.83%
- Packaging
- 50mg
- Price
- $1140
- Updated
- 2021/12/16
- Product number
- CS-7550
- Product name
- inS3-54A18
- Purity
- 99.83%
- Packaging
- 100mg
- Price
- $1920
- Updated
- 2021/12/16
inS3-54A18 Chemical Properties,Usage,Production
Uses
inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.
in vivo
inS3-54A18 (200?mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells[1].
IC 50
STAT3
References
[1] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92. DOI:10.1038/onc.2015.215
[2] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92
inS3-54A18 Preparation Products And Raw materials
Raw materials
Preparation Products
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