ChemicalBook > CAS DataBase List > 3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-

3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-

Product Name: 3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
CAS No.: 1805789-54-1
Chemical Name: 3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
Synonyms: CT7001 hydrochloride;CT7001 HCl;CT 7001 HCl;CT-7001 HCl;1), (3R,4R)-;ICEC0942 (CT7001);PPDA-001 HCL SALT;ICEC 0942 hydrochloride;Samuraciclib HCl (ICEC0942;Samuraciclib hydrochloride
CBNumber: CB03362079
Molecular Formula: C22H31ClN6O
Formula Weight: 430.98
MOL File: 1805789-54-1.mol

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3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- Property

storage temp.: Store at -20°C
solubility: DMSO: Soluble
form: A solid
color: White to light yellow
InChIKey: YMNPLAHCOLEZJE-ALSDZXMDNA-N
SMILES: N(C1=CC(NC[C@H]2CCNC[C@@H]2O)=NC2=C(C(C)C)C=NN12)CC1C=CC=CC=1.Cl |&1:6,11,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C831025
Product name: CT7001Hydrochloride
Packaging: 10mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-0039275
Product name: Samuraciclib(hydrochloride)
Purity: 99.98%
Packaging: 25mg
Price: $980
Updated: 2021/12/16

ChemScene

Product number: CS-0039275
Product name: Samuraciclib(hydrochloride)
Purity: 99.98%
Packaging: 5mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0039275
Product name: Samuraciclib(hydrochloride)
Purity: 99.98%
Packaging: 10mg
Price: $490
Updated: 2021/12/16

ChemScene

Product number: CS-0039275
Product name: Samuraciclib(hydrochloride)
Purity: 99.98%
Packaging: 50mg
Price: $1600
Updated: 2021/12/16

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3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- Chemical Properties,Usage,Production

Uses

CT7001 Hydrochloride, is a selective CDK7 inhibitor.

in vivo

Samuraciclib (ICEC0942; 100 mg/kg; oral gavage; daily; for 14 days; female nu/nu-BALB/c athymic nude mice) treatment inhibits tumor growth by 60% at day 14, and is accompanied by highly significant reductions in PolII Ser2 and Ser5 phosphorylation in PBMCs and in tumors^[1].
? The combination of Samuraciclib (ICEC0942) and ICI 47699 treatment shows complete growth arrest of estrogen receptor (ER)-positive tumor xenografts^[1].

Animal Model:	Female nu/nu-BALB/c athymic nude mice (7-week old) with MCF7 cells^[1]
Dosage:	100 mg/kg
Administration:	Oral gavage; daily; for 14 days
Result:	At day 14, tumor growth was inhibited by 60%.

IC 50

CDK7: 41 nM (IC₅₀); CDK2: 578 nM (IC₅₀); CDK1: 1.8 μM (IC₅₀); CDK4: 49 μM (IC₅₀); CDK5: 9.4 μM (IC₅₀); CDK6: 34 μM (IC₅₀); CDK9: 1.2 μM (IC₅₀)

3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- Suppliers

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1805789-54-1, 3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-Related Search:

3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-

PPDA-001 HCL SALT

ICEC0942 (CT7001)

(3R,4R)-4-(((7-(Benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-olhydrochloride

CT7001 hydrochloride

1), (3R,4R)-

3-Piperidinol, 4-3-(1-methylethyl)-7-(phenylmethyl)aminopyrazolo1,5-apyrimidin-5-ylaminomethyl-, hydrochloride (1

ICEC0942;ICE C0942;ICE-C0942;CT7001;CT-7001;CT 7001

ICEC 0942 hydrochloride

Samuraciclib hydrochloride

Samuraciclib HCl (ICEC0942

CDK,Samuraciclib hydrochloride,CT 7001,ATP-competitive,Samuraciclib,inhibit,Apoptosis,deregulation,Inhibitor,CT7001,non-covalent,phosphorylates,ICEC-0942,anti-tumor,CT-7001,Asp155,cycle,CDK7,ICEC 0942,arrest,ICEC0942,PolII,Cyclin dependent kinase

CT 7001 HCl

CT7001 HCl

CT-7001 HCl

Damuraciclib hydrochloride

Samuraciclib hydrochloride（CT7001 hydrochloride）

Samuraciclib hydrochloride, 10 mM in DMSO

Samuraciclib (ICEC0942) hydrochloride

Samuraciclib hydrochloride (ICEC0942 hydrochloride) ，S8722

1805789-54-1