ChemicalBook > CAS DataBase List > 3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
- Product Name
- 3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
- CAS No.
- 1805789-54-1
- Chemical Name
- 3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
- Synonyms
- CT7001 hydrochloride;CT7001 HCl;CT 7001 HCl;CT-7001 HCl;1), (3R,4R)-;ICEC0942 (CT7001);PPDA-001 HCL SALT;ICEC 0942 hydrochloride;Samuraciclib HCl (ICEC0942;Samuraciclib hydrochloride
- CBNumber
- CB03362079
- Molecular Formula
- C22H31ClN6O
- Formula Weight
- 430.98
- MOL File
- 1805789-54-1.mol
More
Less
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: Soluble
- form
- A solid
- color
- White to light yellow
- InChIKey
- YMNPLAHCOLEZJE-ALSDZXMDNA-N
- SMILES
- N(C1=CC(NC[C@H]2CCNC[C@@H]2O)=NC2=C(C(C)C)C=NN12)CC1C=CC=CC=1.Cl |&1:6,11,r|
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- C831025
- Product name
- CT7001Hydrochloride
- Packaging
- 10mg
- Price
- $540
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0039275
- Product name
- Samuraciclib(hydrochloride)
- Purity
- 99.98%
- Packaging
- 25mg
- Price
- $980
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0039275
- Product name
- Samuraciclib(hydrochloride)
- Purity
- 99.98%
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0039275
- Product name
- Samuraciclib(hydrochloride)
- Purity
- 99.98%
- Packaging
- 10mg
- Price
- $490
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0039275
- Product name
- Samuraciclib(hydrochloride)
- Purity
- 99.98%
- Packaging
- 50mg
- Price
- $1600
- Updated
- 2021/12/16
More
Less
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- Chemical Properties,Usage,Production
Uses
CT7001 Hydrochloride, is a selective CDK7 inhibitor.
in vivo
Samuraciclib (ICEC0942; 100 mg/kg; oral gavage; daily; for 14 days; female nu/nu-BALB/c athymic nude mice) treatment inhibits tumor growth by 60% at day 14, and is accompanied by highly significant reductions in PolII Ser2 and Ser5 phosphorylation in PBMCs and in tumors[1].
?
The combination of Samuraciclib (ICEC0942) and ICI 47699 treatment shows complete growth arrest of estrogen receptor (ER)-positive tumor xenografts[1].
| Animal Model: | Female nu/nu-BALB/c athymic nude mice (7-week old) with MCF7 cells[1] |
| Dosage: | 100 mg/kg |
| Administration: | Oral gavage; daily; for 14 days |
| Result: | At day 14, tumor growth was inhibited by 60%. |
IC 50
CDK7: 41 nM (IC50); CDK2: 578 nM (IC50); CDK1: 1.8 μM (IC50); CDK4: 49 μM (IC50); CDK5: 9.4 μM (IC50); CDK6: 34 μM (IC50); CDK9: 1.2 μM (IC50)
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less