CMP5

Product Name: CMP5
CAS No.: 1030021-40-9
Chemical Name: CMP5
Synonyms: CMP5;CMP-5 hydrochloride;CMP-5 hydrochloride (PRMT5-IN-5);CMP 5 hydrochloride,CMP5 hydrochloride
CBNumber: CB03364109
Molecular Formula: C21H22ClN3
Formula Weight: 351.88
MOL File: 1030021-40-9.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem

Product number: Axon2709
Product name: CMP5
Purity: 99%
Packaging: 10mg
Price: $104.5
Updated: 2021/12/16

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CMP5 Chemical Properties,Usage,Production

Description

CMP5 is a potent and selective PRMT5 Inhibitor. CMP5 showed to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 μM. CMP-5 shows promise as a novel therapeutic_x000D_ approach for B-cell lymphomas.

Uses

CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected[1][2].

References

[1] Alinari L, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.Blood. 2015 Apr 16;125(16):2530-43. DOI:10.1182/blood-2014-12-619783
[2] Webb LM, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol.?2017?Feb 15;198(4):1439-1451. DOI:10.4049/jimmunol.1601702

CMP5 Preparation Products And Raw materials

Raw materials

Preparation Products

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CMP5 Suppliers

China 8 Finland 2 United States 3 USA 1 Global 14

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
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TargetMol Chemicals Inc.

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

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Country: China
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Jinan Jiuli Biotechnology Co. , Ltd.

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TargetMol Chemicals Inc.

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Nanjing Shizhou Biology Technology Co.,Ltd

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Biosynth Biological Technology (Suzhou) Co Ltd

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TargetMol Chemicals Inc.

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Country: United States
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Guangzhou Yiran Biotechnology Co., Ltd.

Tel: 15571990006
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1030021-40-9, CMP5Related Search:

CMP-5 hydrochloride (PRMT5-IN-5)

CMP5

CMP-5 hydrochloride

CMP 5 hydrochloride,CMP5 hydrochloride

1030021-40-9