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CMP5

Product Name
CMP5
CAS No.
1030021-40-9
Chemical Name
CMP5
Synonyms
CMP5;CMP-5 hydrochloride;CMP-5 hydrochloride (PRMT5-IN-5);CMP 5 hydrochloride,CMP5 hydrochloride
CBNumber
CB03364109
Molecular Formula
C21H22ClN3
Formula Weight
351.88
MOL File
1030021-40-9.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem
Product number
Axon2709
Product name
CMP5
Purity
99%
Packaging
10mg
Price
$104.5
Updated
2021/12/16
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CMP5 Chemical Properties,Usage,Production

Description

CMP5 is a potent and selective PRMT5 Inhibitor. CMP5 showed to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 μM. CMP-5 shows promise as a novel therapeutic_x000D_ approach for B-cell lymphomas.

Uses

CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected[1][2].

References

[1] Alinari L, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.Blood. 2015 Apr 16;125(16):2530-43. DOI:10.1182/blood-2014-12-619783
[2] Webb LM, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol.?2017?Feb 15;198(4):1439-1451. DOI:10.4049/jimmunol.1601702

CMP5 Preparation Products And Raw materials

Raw materials

Preparation Products

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CMP5 Suppliers

China 8 Finland 2 United States 3 USA 1 Global 14
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
19961
Advantage
58
Axon Medchem LLC
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
United States
ProdList
763
Advantage
58

1030021-40-9, CMP5Related Search:


  • CMP-5 hydrochloride (PRMT5-IN-5)
  • CMP5
  • CMP-5 hydrochloride
  • CMP 5 hydrochloride,CMP5 hydrochloride
  • 1030021-40-9