Azido-PEG3-Val-Cit-PAB-OH
- Product Name
- Azido-PEG3-Val-Cit-PAB-OH
- CAS No.
- 2055024-65-0
- Chemical Name
- Azido-PEG3-Val-Cit-PAB-OH
- Synonyms
- N3-PEG3-Val-Cit-PAB;Azido-PEG3-Val-Cit-PAB-OH
- CBNumber
- CB03373569
- Molecular Formula
- C27H44N8O8
- Formula Weight
- 608.7
- MOL File
- 2055024-65-0.mol
Azido-PEG3-Val-Cit-PAB-OH Property
- solubility
- Soluble in Water, DMSO, DMF
N-Bromosuccinimide Price
- Product number
- BP-23206
- Product name
- Azido-PEG3-Val-Cit-PAB-OH
- Purity
- 96%
- Packaging
- 500mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- BP-23206
- Product name
- Azido-PEG3-Val-Cit-PAB-OH
- Purity
- 96%
- Packaging
- 1g
- Price
- $1390
- Updated
- 2021/12/16
Azido-PEG3-Val-Cit-PAB-OH Chemical Properties,Usage,Production
Description
Azido-PEG3-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility.
Uses
Azido-PEG3-Val-Cit-PAB-OH is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG3-Val-Cit-PAB-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
Protease Cleavable Linker; Cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
Azido-PEG3-Val-Cit-PAB-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azido-PEG3-Val-Cit-PAB-OH manufacturers
- Product
- Azido-PEG3-Val-Cit-PAB-OH 2055024-65-0
- Price
- US $0.00/mg
- Min. Order
- 250mg
- Purity
- >98.00%
- Supply Ability
- 250mg
- Release date
- 2024-03-29