BTSA 1
- Product Name
- BTSA 1
- CAS No.
- 314761-14-3
- Chemical Name
- BTSA 1
- Synonyms
- BTSA 1;CS-2853;BTSA1 ，S8650;BTSA 1;BTSA-1;BTSA1 >=98% (HPLC);BTSA1, 10 mM in DMSO;1H-Pyrazole-4,5-dione, 3-phenyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(2-thiazolyl)hydrazone];5-Phenyl-2-(4-phenyl-thiazol-2-yl)-4-(thiazol-2-yl-hydrazono)-2,4-dihydro-pyrazol-3-one;5-Phenyl-2-(4-phenylthiazol-2-yl)-4-(2-(thiazol-2-yl)hydrazono)-2,4-dihydro-3H-pyrazol-3-one;inhibit,FITC-BIM,caspase-3/7,translocation,Bcl-2 Family,viability,Inhibitor,BTSA1,mitochondrial,pharmacologically,BAX,AML,BTSA 1,BTSA-1,SAHBA2,Apoptosis
- CBNumber
- CB03374627
- Molecular Formula
- C21H14N6OS2
- Formula Weight
- 430.51
- MOL File
- 314761-14-3.mol
BTSA 1 Property
- Boiling point:
- 625.2±48.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:53.0(Max Conc. mg/mL);123.11(Max Conc. mM)
- pka
- 6.52±0.40(Predicted)
- form
- Solid
- color
- Brown to reddish brown
- InChI
- InChI=1S/C21H14N6OS2/c28-19-18(24-25-20-22-11-12-29-20)17(15-9-5-2-6-10-15)26-27(19)21-23-16(13-30-21)14-7-3-1-4-8-14/h1-13H,(H,22,25)
- InChIKey
- KYVZVVOQWWCVPP-UHFFFAOYSA-N
- SMILES
- N1(C2=NC(C3=CC=CC=C3)=CS2)C(=O)C(=NNC2=NC=CS2)C(C2=CC=CC=C2)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML2243
- Product name
- BTSA1
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $105
- Updated
- 2025/07/31
- Product number
- SML2243
- Product name
- BTSA1
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $338
- Updated
- 2025/07/31
- Product number
- CD31005001
- Product name
- BTSA1
- Purity
- 98%
- Packaging
- 25mg
- Price
- $514
- Updated
- 2021/12/16
- Product number
- 012494
- Product name
- BTSA1
- Packaging
- 001
- Price
- $700
- Updated
- 2021/12/16
- Product number
- CD31005001
- Product name
- BTSA1
- Purity
- 98%
- Packaging
- 50mg
- Price
- $775
- Updated
- 2021/12/16
BTSA 1 Chemical Properties,Usage,Production
Uses
BTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis[1].
Biological Activity
BTSA1 is a BAX activator that binds to its N-terminal activation site with high affinity and specificity, induces a conformational change in BAX, and causes BAC-mediated apoptosis. It efficiently promotes apoptosis in leukemia cell lines and patient samples without affecting healthy cells.
in vivo
BTSA1 effectively inhibits human acute myeloid leukemia xenografts and enhances host survival without toxic side effects. In mice, it was well tolerated.
target
| Target | Value |
| Bax () |